A5045478998- Erythrocyte Function and Pathophysiology
- Lymphoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Chronic Lymphocytic Leukemia Research
- Shoulder and Clavicle Injuries
- Hemoglobinopathies and Related Disorders
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- CRISPR and Genetic Engineering
- Bone Tumor Diagnosis and Treatments
- Epigenetics and DNA Methylation
- Bacterial Genetics and Biotechnology
- Acute Myeloid Leukemia Research
- Circular RNAs in diseases
- Shoulder Injury and Treatment
- RNA modifications and cancer
- Galectins and Cancer Biology
- Toxin Mechanisms and Immunotoxins
- Multiple Myeloma Research and Treatments
- Nanoplatforms for cancer theranostics
- Spinal Cord Injury Research
- Multiple and Secondary Primary Cancers
- Microtubule and mitosis dynamics
Henan Cancer Hospital
2017-2025
Zhengzhou University
2017-2025
University of Oxford
2023-2024
University of Nottingham Ningbo China
2014-2024
Tianjin Medical University
2012-2017
Zhejiang University
2017
Second Affiliated Hospital of Zhengzhou University
2017
Beihai People's Hospital
2015
Sichuan University
2005
Due to the adverse effects of erythropoietin (EPO) on cancer patient survival, it is necessary develop new agents that can be used efficiently manage and treat cancer-related anemia. In this study, novel distinctive carbon dots, J-CDs, derived from jujube are designed, synthesized, characterized. Based obtained results, material comprises sp2 sp3 atoms, as well oxygen/nitrogen-based groups, specifically promotes proliferation erythroid cells by stimulating self-renewal progenitor in vitro...
For the study, we determine potential biomarkers and uncover regulatory mechanisms of lncRNA MALAT1 / miR-145 SOX9 axis on abilities cell growth metastasis colorectal cancer.Previously published dataset GSE18105 from GEO database was used for microarray analysis to identify differential-expressed lncRNAs mRNAs. The miRNA which had targeted relationships with both mRNA predicted using miRCode Targetscan. association between miRNA, verified dual-luciferase reporter assay. Expression levels...
Abstract Background Triple-negative breast cancer (TNBC) is a highly aggressive malignant disease with high rate of recurrence and metastasis, few effective treatment options poor prognosis. Here, we designed constructed combined photothermal immunotherapy strategy based on cell membrane-coated biomimetic black phosphorus quantum dots (BBPQDs) for tumor-targeted therapy anti-PD-L1 mediated immunotherapy. Results BBPQDs have good conversion efficiency can efficiently target tumor cells...
The aim of this study was to correlate matrix metalloproteinase-2 and metalloproteinase-9 expression with the clinicopathological features outcome patients early gastric cancer clinically elucidate more information on role protein overexpression regard lymph node metastasis cancer. levels were assessed by immunohistochemistry. An association observed between metalloproteinase-2, metalloproteinase-9, metalloproteinase-2/matrix factors, such as ulceration metastasis. Furthermore, both strongly...
Cancer vaccines are a promising therapeutic approach in cancer immunotherapy and can inhibit tumor growth prevent recurrence metastasis by activating sustained antitumor immunoprotective effect. However, the effect of is severely weakened low immunogenicity antigens immunosuppressive microenvironment tissues.Here, we report novel hybrid membrane nanovaccine, composed mesoporous silica nanoparticle as delivery carrier, cell membranes obtained from dendritic cells cells, R837 an immune...
Relatively little information is available on quantitative risks of therapy-induced second malignant neoplasm (SMN) in patients with non-Hodgkin lymphoma (NHL). A nested case-control study was conducted a cohort 3412 treated for NHL between 1990 and 2006, including 118 SMN 472 controls. Risks leukemia/lung/breast/colorectal bladder cancer were higher compared the general population. risk leukemia restricted to given cumulative dose cyclophosphamide more than 11 250 mg/m(2). However, no...
Abstract Anthracycline-based chemotherapy resistance represents a major challenge in diffuse large B-cell lymphoma (DLBCL). MiRNA and gene expression profiles ( n = 47) were determined to uncover potential chemoresistance mechanisms therapeutic approaches. An independent correlation between high of miRNA-363-3p was observed validated larger cohort 106). MiRNA-363-3p shown reduce doxorubicin-induced apoptosis tumor shrinkage vitro vivo experiments by ectopic CRISPR/Cas9-mediated knockout...
To investigate the effects of bone density, plate bending degree and proximal screw type on stress fracture clavicle hook. Three sows weighing between 45 50 kg were selected, from which a total 40 rivs collected. The 15 ribs divided into 3 groups according to density hardness with 5 in each group. And then fixed 6-hole collarbone hook plates locking screws. Measure maximum torsion force when fractured by force. same size rids groups, named forward group, 0° group(the angle surface rib...
Abstract Encounters between replication forks and unrepaired single-strand DNA breaks (SSBs) generate single-ended double-strand (seDSBs) that can later become double-ended (deDSBs) through fork convergence. seDSBs be repaired by break-induced (BIR), which is a highly mutagenic pathway thought to repsonsible for many of the mutations genome rearrangements drive cancer development. However, frequency BIR’s deployment its ability triggered both leading lagging template strand SSBs was unclear....
After spinal cord injury (SCI), the disruption of blood-spinal barrier by activation endothelin (ET) system is a critical event leading to leukocyte infiltration, inflammatory response and oxidative stress, contributing neurological disability. In present study, we showed that blockade ET receptor A (ETAR) and/or B (ETBR) prevented early responses directly via inhibition neutrophil monocyte diapedesis mediator production following traumatic SCI in mice. Long-term improvement, based on series...
Following spinal cord trauma, mitochondrial dysfunction associated with increased oxidative stress is a critical event leading to leukocyte inflammatory responses, neuronal cell death and demyelination, contributing permanent locomotor neurological disability. The present study demonstrated that the enhancer N‑acetylcysteine (NAC) may restore redox balance via enhancement of respiratory activity following traumatic injury (SCI). In addition, NAC ameliorates stress‑induced loss, infiltration...
Osteosarcoma (OS) is a common malignant bone cancer threatening children and young adults. Emerging evidence indicates that long non-coding RNAs (lncRNAs) play crucial roles in the progression of OS. Herein, we want to clarify lncRNA human leukocyte antigen complex group 11 (HCG11) Our data revealed HCG11 expression decreased OS, which result transcriptional repression YY1. Low level closely associated with larger tumor size shorter overall survival OS patients. negatively regulates cell...
A β-1,3-glucanase was isolated from Jatropha curcas using Sephadex G-75, SP Sepharose FF and HiPrepSephacrayS-100HR chromatography columns, successively. It exhibited a molecular weight (Mr) of 65-66kD consisting three sub-units with non-covalent bond conjugate, as estimated 8% (w/v) polyacrylamide gel electrophoresis (PAGE), 5–20% sodium dodecyl sulfate gradient (SDS-gradient PAGE) filtration on G-75 column, respectively. The protein had an isoelectric point (pI) 8.3 shown by focusing...
The present study aimed to investigate microRNA-376a (miR-376a) expression in lymphoma, and the effect of miR-376a on cell proliferation apoptosis at cytological molecular levels. lymphoma issue cells was detected by reverse transcription quantitative polymerase chain reaction (RT-qPCR), forkhead box protein P2 (FOXP2) RT-qPCR western blot analysis, were studied an MTT assay flow cytometry, respectively. Additionally, levels cyclin D2, A, B, apoptosis-associated proteins B-cell 2 (Bcl-2)...
Generation of mammalian red blood cells requires the expulsion polarized nuclei late in terminal erythroid differentiation. However, mechanisms by which spherical erythroblasts determine direction nuclear polarization and maintain asymmetry during are poorly understood. Given analogy erythroblast enucleation to asymmetric cell division key role Aurora kinases mitosis, we sought investigate function enucleation. We found that AURKA (Aurora kinase A) is abundantly expressed orthochromatic...
To investigate the effects of zoledronic acid on muscle metabolism in mice with osteoporosis and sarcopenia elucidate possible underlying mechanism. Twenty-four 8-week-old male C57BL/6J were randomly divided into four groups: non-suspension (N-SUS), suspension (SUS), + (ZA), PTH(PTH) groups. Equal doses saline, acid, PTH administered subcutaneously. After 4 weeks, sacrificed, body weight mass (gastrocnemius soleus) measured, right tibia was taken for micro-CT examination, specimens analyzed...
Polo-like kinase 1 (PLK1), a key regulator of the G2/M phase in mitosis, is frequently overexpressed numerous tumors. Although PLK1 inhibitors have emerged as promising therapeutic agents for cancer, their use has been linked to significant anemia subset patients, yet underlying mechanisms remain poorly understood. In this study, we utilized an vitro human umbilical cord blood-derived CD34 + cell-based erythroid differentiation system, alongside murine model, investigate impact on...
Abstract Objective: Extranodal involvement represents a peculiar presentation of diffuse large B-cell lymphoma (DLBCL). Previous studies have suggested that older patients are more prone to extranodal involvement. This study retrospectively addressed the distribution, prognostic value and treatment options in young with DLBCL. Methods: A total 329 were enrolled according inclusion requirements. The effects gender, involvement, age-adjusted international index (aaIPI), rituximab infusion...
There are no published studies of the influence geometry scapula on postoperative recovery rotator cuff injuries. Our aim was to explore relationship between critical shoulder angle (CSA), acromion index (AI), glenoid inclination (GI), and repair outcomes in joints after arthroscopic supraspinatus tendon repair.Sixty two patients suffering a tear were analyzed retrospectively following failure conservative treatment subsequent arthroscopy our hospital. Standard anterior posterior X-rays...
Abstract Background Early progression after the first-line R-CHOP treatment leads to a very dismal outcome and necessitates alternative for patients with diffuse large B-cell lymphoma (DLBCL). This study aimed develop genetic predictive model early evaluate its potential in advancing treatment. Methods Thirty-two hotspot driver genes were examined 145 DLBCL 5 cell lines using next-generation sequencing. The association of clinical features, cell-of-origin, double expression, positive p53...
Acute lymphoblastic leukemia (ALL) is a type of hematological malignancy and has poor prognosis. In our study, we aimed to construct prognostic model ALL by identifying important genes closely related We obtained transcriptome data (RNA-seq) samples from the GDC TARGET database identified differentially expressed (DEGs) using "DESeq" package R software. used univariate multivariate cox regression analyses screen out ALL. results, risk score can be as an independent factor predict prognosis...