A5007139691- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Advanced Neural Network Applications
- Advanced Image and Video Retrieval Techniques
- Advanced Breast Cancer Therapies
- Topic Modeling
- Phytochemistry and Bioactive Compounds
- Integrated Circuits and Semiconductor Failure Analysis
- Microbial Natural Products and Biosynthesis
- Reproductive Biology and Fertility
- Histone Deacetylase Inhibitors Research
- Cancer, Lipids, and Metabolism
- Adversarial Robustness in Machine Learning
- Advanced Proteomics Techniques and Applications
- RNA modifications and cancer
- Chromatography in Natural Products
- Multimodal Machine Learning Applications
- Sinusitis and nasal conditions
- Mesenchymal stem cell research
- Phytochemical compounds biological activities
- Allergic Rhinitis and Sensitization
- Bioactive Compounds and Antitumor Agents
- Neuroscience of respiration and sleep
Huazhong University of Science and Technology
2022-2025
Tongji Hospital
2022-2025
Zhejiang University of Technology
2022-2025
University of Florida
2021-2024
Sun Yat-sen Memorial Hospital
2020-2024
Sun Yat-sen University
2020-2024
Second Affiliated Hospital of Jilin University
2024
Shandong Normal University
2024
Shanghai Institute of Organic Chemistry
2023
Chinese Academy of Sciences
2019-2023
Abstract Cyclin D1 is one of the most important oncoproteins that drives cancer cell proliferation and associates with tamoxifen resistance in breast cancer. Here, we identify a lncRNA, DILA1, which interacts overexpressed tamoxifen-resistant cells. Mechanistically, DILA1 inhibits phosphorylation at Thr286 by directly interacting blocking its subsequent degradation, leading to protein Knocking down decreases expression, growth restores sensitivity both vitro vivo. High expression associated...
Many patients with breast cancer still relapse after curative treatment. How to identify the ones high risk remains a critical problem. Circulating tumor DNA (ctDNA) has recently become promising marker monitor burden. Whether ctDNA can be used predict response and prognosis in receiving neoadjuvant chemotherapy (NAC) is unknown. Our study aimed evaluate clinical value of presence dynamic change treated NAC.Fifty-two early who underwent NAC were prospectively enrolled. Serial plasma samples...
Abstract Convolutional neural network (CNN)-based object detectors perform excellently but lack global feature extraction and cannot establish dependencies between pixels. Although the Transformer is able to compensate for this, it does not incorporate advantages of convolution, which results in insufficient information being obtained about details local features, as well slow speed large computational parameters. In addition, Feature Pyramid Network (FPN) lacks interaction across layers,...
CDK4/6 inhibitors (CDK4/6i) plus endocrine therapy are now standard first-line for advanced HR + /HER2 − breast cancer, but developing resistance is just a matter of time in these patients. Here, we report that cyclin E1–interacting lncRNA (EILA) up-regulated CDK4/6i-resistant cancer cells and contributes to CDK4/6i by stabilizing E1 protein. EILA overexpression correlates with accelerated cell cycle progression poor prognosis cancer. Silencing reduces protein restores sensitivity both vitro...
Hypermongones A–J (1–10), rare methylated polycyclic polyprenylated acylphloroglucinol derivatives, together with three known simple acylphloroglucinols (11–13) as their plausible biogenetic precursors, were identified from the flowers of Hypericum monogynum. The structures 1–10 elucidated by analysis 1D and 2D NMR spectroscopic data; absolute configuration skeleton was determined electronic circular dichroism exciton chirality method subsequently confirmed an X-ray diffraction study 1....
Physagulide I induced apoptosis and cell cycle arrest <italic>via</italic> ROS generation the activation of MAPK in human osteosarcoma cells.
Background Chronic rhinosinusitis with polyps (CRSwNP) is a global health concern. Nasal nitric oxide (nNO), clinical biomarker, have been studied to assess the presence of airway mucosal inflammation. This study aimed clarify roles nNO in diagnosis and endotypes CRSwNP. Methods Eighty-two CRSwNP patients thirty healthy volunteers were recruited for this study. The classified into eosinophilic (Eos CRSwNP) non⁃eosinophilic (Non-Eos by tissue eosinophil percentage. levels measured an...
Abstract Metabolites of microorganisms have long been considered as potential sources for drug discovery. In this study, five new depsidone derivatives, talaronins A-E ( 1–5 ) and three xanthone F–H 6–8 ), together with 16 known compounds 9–24 were isolated from the ethyl acetate extract mangrove-derived fungus Talaromyces species WHUF0362. The structures elucidated by analysis spectroscopic data chemical methods including alkaline hydrolysis Mosher’s method. Compounds 1 2 each attached a...
Abstract The porcine‐derived non‐cross‐linked collagen membrane Bio‐gide® (BG) and the bovine‐derived Heal‐all® (HA) were compared to better understand their in vitro biophysical characteristics vivo degradation patterns as a reference for clinical applications. It was showed that porosity, specific surface area, pore volume diameter of BG larger than those HA (64.5 ± 5.2% vs. 48.6 6.1%; 18.6 2.8 m 2 /g 2.3 0.6 /g; 0.114 0.002 cm 3 0.003 0.001 24.4 3.5 nm 7.3 1.7 nm, respectively); average...
Hardware assurance is a key process in ensuring the integrity, security and functionality of hardware device. Its heavy reliance on images, especially Scanning Electron Microscopy makes it an excellent candidate for vision community. The goal this paper to provide pathway inter-community collaboration by introducing existing challenges integrated circuits context computer support further development using large-scale dataset with 800,000 images. A detailed benchmark approaches also included...