A5053182398- Muscle and Compartmental Disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Acute Kidney Injury Research
- Sleep and related disorders
- Renal Diseases and Glomerulopathies
- Renal and related cancers
- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Ginseng Biological Effects and Applications
- Olfactory and Sensory Function Studies
- Circadian rhythm and melatonin
- Chronic Kidney Disease and Diabetes
- Berberine and alkaloids research
- SARS-CoV-2 detection and testing
- Menstrual Health and Disorders
- Bioactive natural compounds
- SARS-CoV-2 and COVID-19 Research
- Ovarian function and disorders
- Thyroid Disorders and Treatments
- Fungal Biology and Applications
- Lymphatic System and Diseases
- Mitochondrial Function and Pathology
- Cholesterol and Lipid Metabolism
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
Huazhong University of Science and Technology
2020-2025
Tongji Hospital
2020-2025
Zunyi Medical University
2022-2025
Hubei University of Medicine
2023
Affiliated Hospital of Zunyi Medical College
2015-2019
Previous studies have shown that astrocyte activation in the anterior cingulate cortex (ACC), accompanied by upregulation of marker S100 calcium binding protein B (S100B), contributes to comorbid anxiety chronic inflammatory pain (CIP), but exact downstream mechanism is still being explored. The receptor for advanced glycation end-products (RAGE) plays an important role and psychosis recognizing ligands, including S100B. Therefore, we speculate RAGE may be involved regulation comorbidity...
Diabetic kidney disease (DKD) is a prevalent microvascular complication of diabetes. Inhibiting the epithelial-mesenchymal transition (EMT) proximal tubule epithelial cells (PTCs) can slow down renal fibrosis. Trigonelline (TRL), an alkaloid isolated from fenugreek, has demonstrated therapeutic effects on diabetes and its complications. Nevertheless, underlying mechanisms for TRL are still obscure. The present study was aimed to evaluate treatment against DKD explore potential mechanisms.The...
Background: Chronic low-grade inflammation is recognized as a key pathophysiological mechanism of insulin resistance. Leukotriene B4 (LTB4), molecule derived from arachidonic acid, potent neutrophil chemoattractant. The excessive amount LTB4 that combined with its receptor BLT1 can cause chronic inflammation, aggravating Berberine (BBR) has been shown to relieve resistance due anti-inflammatory properties. However, it not clear whether BBR could have any effects on the LTB4-BLT1 axis....
Mitochondrial dysfunction is implicated in the progression of diabetic kidney disease (DKD). Damaged mitochondria produce excessive reactive oxygen species (ROS) that can cause apoptosis. dynamics control quality and function mitochondria. Targeting mitochondrial may reduce ROS-induced apoptosis improve renal injury DKD. Modified Hu-lu-ba-wan (MHLBW) shows distinct clinical effects on DKD patients, which are related to its role antioxidant stress modulation. However, relevant mechanisms...
Objective: Diminished ovarian reserve (DOR) is a disorder characterized by impaired function. Sleep disorders are disruptions of the circadian rhythm, which appears to be closely linked reproductive systems. This study aimed investigate impact poor sleep quality on childbearing-age women. Methods: A cross-sectional was conducted in China from June 2021 March 2023. In total, 102 participants diagnosed with chronic insomnia were included study. Questionnaires administered assess participants'...
We screened key angiogenesis-related lncRNAs based on colon adenocarcinoma (COAD) to construct a RiskScore model for predicting COAD prognosis and help reveal the pathogenesis of as well optimize clinical treatment.
Acute kidney injury (AKI), a prevalent complication of sepsis, causes substantial burden on patients' families as well the society. More reliable markers are urgently required for prevention and treatment AKI. Pleckstrin homology-like domain, family A, member 1 (PHLDA1) was implicated in various diseases, but its involvement sepsis-induced AKI remains to be explored. The JNK/ERK pathway has been revealed being involved progression sepsis. One previous study demonstrated that PHLDA1 could...
This study aimed to investigate the effects of Ang-1 on neovascularization diabetic organs by subcutaneous Matrigel angiogenesis model, established in type 1 rats.Ang-1 adenoviral vector was constructed. The rat model STZ and divided into four group. inserted subcutaneously abdominal cavity rats at 8 weeks, treatment group injected with adenovirus via tail vein, were sacrificed 10 weeks. Neovascularization observed transmission electron microscopy. marker vascular endothelial cell pericyte...
To evaluate the early predictive and diagnostic significance of acute kidney injury (AKI) associated biomarkers for patients in intensive care unit (ICU). From January to June, 2014, relevant clinical data participants were collected upon admission (ICU) Affiliated Hospital Zunyi Medical College. Levels serum cystatin C (sCys C), neutrophil gelatinase-associated lipocalin (sNGAL), urinary (uNGAL), molecule-1 (uKIM-1), interleukin-18 (uIL-18), N-acetyl-beta-D-glucosaminidase (uNAG) detected...
Positive nucleic acid (NA) results have been found in recovered and discharged COVID-19 patients, but the proportion is unclear. This study was designed to analyze recurrent positive rate of NA after consecutively negative results, relationship between specific antibody production rate. According Strengthening Reporting Observational Studies Epidemiology guidelines, data inpatients Sino-French New City Branch Tongji Hospital Jan. 28 Mar. 6, 2020 were collected. A total 564 patients over 14...
To study the role of thromboelastogram (TEG) and routine coagulation indexes in evaluating severity acute pancreatitis (AP) early stage onset. A total 123 patients with treated at our hospital from January 2018 to 2021 were divided into three groups according their disease severity. We analyzed correlation prognostic significance TEG, blood platelet (PLT) count The clot reaction time (R-value), generation (K-value), maximum width value (MA-value) rate (α-angle) between significantly...