A5109421367- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Adipokines, Inflammation, and Metabolic Diseases
- Meat and Animal Product Quality
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Lipid metabolism and biosynthesis
- NF-κB Signaling Pathways
- Retinoids in leukemia and cellular processes
- interferon and immune responses
- RNA modifications and cancer
- Plant biochemistry and biosynthesis
- Aquaculture Nutrition and Growth
- Epigenetics and DNA Methylation
- Advanced Photocatalysis Techniques
- Advanced Surface Polishing Techniques
- MicroRNA in disease regulation
- Advanced machining processes and optimization
- Circular RNAs in diseases
- Cancer-related gene regulation
- Mesenchymal stem cell research
- RNA Research and Splicing
- Biochemical and biochemical processes
- RNA regulation and disease
- Plant Molecular Biology Research
Education Department of Heilongjiang Province
2016-2023
Northeast Agricultural University
2012-2023
Ministry of Agriculture and Rural Affairs
2019-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Kunming University of Science and Technology
2022-2023
Fujian University of Technology
2023
Harbin Institute of Technology
2021
The University of Tokyo
2019
Layered double hydroxide (LDH)-based photocatalysts have attracted more attention in photocatalysis due to their low cost, wide band gaps, and adjustable photocatalytic active sites; however, photogenerated carrier separation efficiency limits efficiency. Herein, a NiAl-LDH/Ni-doped Zn0.5Cd0.5S (LDH/Ni-ZCS) S-scheme heterojunction is rationally designed constructed from kinetically thermodynamically favorable angles. The 15% LDH/1% Ni-ZCS displays comparable hydrogen evolution (PHE) activity...
In avian species, liver is the main site of de novo lipogenesis, and hepatic lipid metabolism relates closely to adipose fat deposition. Using our lean chicken lines striking differences in abdominal content, post-hatch both tissues has been studied extensively. However, whether molecular discrepancy for exists embryos remains obscure.We performed transcriptome proteome profiling on livers at five embryonic stages (E7, E12, E14, E17 E21) between lines. At each stage, 521, 141, 882, 979 169...
Abstract Optical surface measurement and characterization precision are significantly influenced by the performance of registration methods. Most existing optical methods suffer from poor efficiency or lower precision. To address these challenges, this investigation proposes a hierarchical method based on meta - heuristic algorithm, primarily targeting freeform grid surfaces(relatively simple non-rotationally symmetric surfaces) rotationally surfaces in applications. First, to enhance avoid...
One of the main objectives broiler breeding is to prevent excessive abdominal adipose deposition. The role RNA modification in deposition not clear. This study was aimed map m 6 A landscape chicken tissue. MeRIP-seq performed compare differences methylation pattern between fat and lean broilers. We found that start codons, stop coding regions, 3′-untranslated regions were generally enriched for peaks. high methylated genes (fat birds vs. birds) primarily associated with fatty acid...
Through posttranscriptional gene regulation, microRNA (miRNA) is linked to a wide variety of biological processes, including adipogenesis and lipid metabolism. Although miRNAs in mammalian have been worked on extensively, their study chicken still very limited. To find potentially important for preadipocyte development, we compared the miRNA expression profiles two broiler lines divergently selected abdominal fat content, by sequencing small RNA libraries constructed primary preadipocytes...
The transcription factor TCF21 has been previously shown to be specifically expressed in white preadipocytes mice. However, the exact biological function of context adipogenesis remains unknown. In current study, we used chicken lines selected based on their abdominal fat content, and observed a significant decrease mRNA protein levels lean broilers relative broilers. Moreover, expression increased throughout preadipocyte differentiation vitro. We also found that knockdown over-expression...
The preadipocyte differentiation biological process involves a cascade of transcriptional events that culminates in the expression peroxisome proliferator-activated receptor (PPAR) γ. cocktail [insulin (INS), dexamethasone (DEX) and isobutylmethylxanthine (IBMX)] can induce mammals, but it is insufficient for chicken (Gallus gallus) adipogenesis. Oleate differentiation, these differentiated preadipocytes may not be fully functional. objective current study was to evaluate whether induced...
Abstract Background Excessive deposition of abdominal fat poses serious problems in broilers owing to rapid growth. Recently, the evolution existing knowledge on long non-coding RNAs (lncRNAs) and circular (circRNAs) have established their indispensable roles multiple physiological metabolic processes, including adipogenesis deposition. However, not much has been explored profiles tissues date. In study, we aimed characterize vital candidates lncRNAs circRNAs underlying regulations for...
As a central constituent of HDL (high-density lipoprotein), apolipoprotein A-I (ApoA-I) has vital function in lipid metabolism. Our previous studies confirmed that ApoA-I was differentially expressed the adipose tissue abdomen lean and fat broilers. The aim current work to evaluate whether transcription chicken abdominal regulated by DNA methylation. methylation status promoter CpG island (PCGI) non-CpG (PNCGI) as well expression level broilers were determined using Sequenom MassARRAY...
The deposition of high levels fat in broiler breeder hens can have a profound impact on follicular development and laying performance. This study was formulated with the goal comparing egg production characteristics at different stages Northeast Agricultural University lines divergently selected for abdominal content (NEAUHLF). analyzed using birds from 19th – 24th generations NEAUHLF; were by hematoxylin-eosin staining quantitative real-time polymerase chain reaction generation NEAUHLF....
Bone morphogenetic protein 4 (BMP4) has been reported to regulate adipose development, but its role in preadipocyte proliferation not explored vitro. Here, we investigated the effect of BMP4 on chicken using immortalized preadipocytes (ICP1 cells) as a cell model. We report that expression increases during proliferation. Overexpression and knockdown promotes inhibits proliferation, respectively. In addition, overexpression decreased number at G0/G1 phase cycle, increased proportion cells S...
The present study aimed to search for chicken abdominal fat deposition-related polymorphisms within RB1 and provide functional evidence significantly associated genetic variants. Association analyses showed that 11 single nucleotide (SNPs) in intron 17 of RB1, were with both weight (P < 0.05) percentage 0.05). Functional analysis revealed the A allele g.32828A>G repressed transcriptional efficiency vitro, through binding nuclear factor-kappa B (NF-KB) SRY-related HMG box protein 2 (SOX2)....
The molecular mechanisms of transcription factor 21 (TCF21) in regulating chicken adipogenesis remain unclear. Thus, the current study was designed to investigate signaling pathway mediating effect TCF21 on adipogenesis. Immortalized preadipocytes cell line (ICP), a preadipocyte stably overexpressing (LV-TCF21) and control (LV-control) were used study. We found that phosphorylation c-Jun N-terminal kinases (JNK) significantly elevated LV-TCF21 compared LV-control. After treating ICP cells...
Previous studies have reported that the -methyladenosine demethylase ALKBH5 can regulate adipogenesis in humans. However, its function birds remains unclear. In this study we aimed to explore expression and of gene chicken adipose tissue. The results showed is widely expressed various tissues, relatively higher abdominal addition, tissue lean broilers than fat at 2 3 weeks age. Moreover, proliferation differentiation preadipocytes are associated with reduced increased , respectively. We also...
Abstract A batch experiment was used to investigate the influence of common heavy metals Cr(VI), NI(II), Cu(II) on sulfur autotrophic short-cut denitrification. Experimental results show that low concentrations (1-3 mg/L) have little effect shortcut denitrification, and high (4-10 obvious effects Inhibition. The doserape model is fit doseeffect curve metals, IC 50 judge toxicity. order each metal is: Cr(VI)>NI(II)>Cu(II). two in binary system NI(II) are antagonistic.
The Northeast Agricultural University broiler lines divergently selected for abdominal fat content (NEAUHLF) were used in the current study to investigate effects of Retinoblastoma1 (RB1) gene on chicken body weight (BW).The single nucleotide polymorphisms (SNPs) individuals detected by MALDI-TOF-MS and PCR-RFLP methods genotypes 27 SNPs obtained.Haplotypes constructed liding window approach.Association analysis between haplotypes conducted, respectively.Based results haplotype association...