A5101916297- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ovarian cancer diagnosis and treatment
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Cervical Cancer and HPV Research
- MicroRNA in disease regulation
- PARP inhibition in cancer therapy
- Cancer, Lipids, and Metabolism
- RNA Research and Splicing
- Endometrial and Cervical Cancer Treatments
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- FOXO transcription factor regulation
- Reproductive Biology and Fertility
- Trace Elements in Health
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Magnesium in Health and Disease
- Radiomics and Machine Learning in Medical Imaging
- Cancer Mechanisms and Therapy
- Obsessive-Compulsive Spectrum Disorders
- GDF15 and Related Biomarkers
Hunan Cancer Hospital
2019-2025
Central South University
2016-2025
Wuhan Polytechnic University
2024-2025
Sun Yat-sen University
2023-2024
Xiangya Hospital Central South University
2015-2021
PharmacoGenetics (China)
2015-2021
Jilin University
2018
Union Hospital
2018
Tzu Chi University
2017
University of Florida
2016
Pharmacologic inhibition of PARP is the primary therapeutic strategy for BRCA mutant ovarian cancer. However, most patients carry wild-type BRCA1/2 with no significant clinical benefits from inhibitors, calling needs to further understanding and developing new when employing inhibitors treat Here, we show that ferroptosis, a form regulated cell death driven by iron-dependent phospholipid peroxidation, partly responsible efficacy inhibitor olaparib. Mechanistically, pharmacological or genetic...
Abstract Cellular metabolism is the fundamental process by which cells maintain growth and self‐renewal. It produces energy, furnishes raw materials, intermediates for biomolecule synthesis, modulates enzyme activity to sustain normal cellular functions. foundation of life processes plays a regulatory role in various biological functions, including programmed cell death. Ferroptosis recently discovered form iron‐dependent The inhibition ferroptosis crucial tumorigenesis tumor progression....
Abstract Background The epithelial-mesenchymal transition (EMT) is crucial for metastasis and positively regulated by calcium-related signaling. melastatin-related transient receptor potential 7 (TRPM7) regulates a non-selective cation channel promotes cancer metastasis. However, the mechanisms underlying action of TRPM7 in ovarian are unclear. Methods expression EMT markers (Vimentin, N-cadherin, Twist E-cadherin) samples was detected. TRPM7was knockdown shRNA Ovarian cell lines to examine...
Abstract Cancer metabolic reprogramming enhances its malignant behaviors and drug resistance, which is regulated by POU domain transcription factors. This study explored the effect of class 2 factor 1 (POU2F1) on in colon cancer. The POU2F1 expression was analyzed GEO dataset, TCGA cohorts human cancer tissues bioinformatics immunohistochemistry. effects altered proliferation, glucose metabolism oxaliplatin sensitivity cells were tested. impacts aldolase A (ALDOA) examined. We found that...
Abstract Background Tumor cell metabolic reprogramming is crucial for the malignant behavior of cancer cells by promoting their proliferation. However, little known on how transient receptor potential 7 (TRPM7) modulates in ovarian cancer. Methods The effects TRPM7 silencing transcriptome profile, glucose uptake, lactic acid production, extracellular acidification rate (ECAR), oxygen consumption (OCR), intracellular ROS and ATP levels, NAD+/NADH ratios were examined. impacts levels...
Ferritinophagy, a process involving selective autophagy of ferritin facilitated by nuclear receptor coactivator 4 (NCOA4), entails the recognition NCOA4 and subsequent delivery to autophagosome. Within autophagosome, undergoes degradation, leading release iron in lysosome. It is worth noting that excessive levels can trigger cell death. Recent evidence has elucidated significant roles played ferritinophagy ferroptosis regulation initiation progression cancer. Given crucial role tumor...
Colorectal cancer (CRC) is the second most common malignant tumor worldwide, and its incidence rate increases annually. Early diagnosis treatment are crucial for improving prognosis of patients with colorectal cancer. Circular RNAs noncoding a closed-loop structure that play significant role in development. However, circular CRC poorly understood.
Abstract One of the key features cancer is energy metabolic reprogramming which tightly related to proliferation, invasion, metastasis, and chemotherapy resistance. NcRNAs are a class RNAs having no protein-coding potential mainly include microRNAs, lncRNAs circRNAs. Accumulated evidence has suggested that ncRNAs play an essential role in regulating reprogramming, altered networks mediated by primarily drive carcinogenesis expression enzymes transporter proteins. Importantly, accumulated...
Oral cancer represents a significant proportion of head and neck malignancies, accounting for approximately 3 % all malignant tumors worldwide. Alternative splicing (AS), post-transcriptional regulatory mechanism, is increasingly linked to development. The precise impact AS on oral progression not well understood. Bioinformatics, semi-quantitative RT-PCR, minigene reporter system detect the skipping SLC37A4 exon 7 in cancer. FRAP, live cell immunofluorescence demonstrates that SRSF9 can...
Abstract Our previous studied indicated that eukaryotic translation initiation factor 3a (eIF3a) increases the sensitive of platinum-based chemotherapy in lung cancer. MiRNAs play an important role carcinogenesis and drug response. In this study, we aimed to identify potential endogenous miRNAs inhibit eIF3a expression determine their influence inhibition on cisplatin resistance. Using bioinformatics analysis prediction confirmation with dual-luciferase reporter assays, found miRNA-488...
High-grade serous ovarian carcinoma (HGSOC) originates mainly from the fallopian tube (FT) epithelium and always carries early TP53 mutations. We previously reported that tumors initiate in FT fimbria because of apoptotic failure expansion cells with DNA double-strand breaks (DSB) caused by bathing epithelial reactive oxygen species (ROSs) hemoglobin-rich follicular fluid (FF) after ovulation. Because ovulation is frequent HGSOC rare, we hypothesized luteal-phase progesterone (P4) could...
Poly (adenosine 5′-diphosphate-ribose) polymerase inhibitors (PARPi) are increasingly important in the treatment of ovarian cancer. However, more than 40% BRCA1/2- deficient patients do not respond to PARPi, and BRCA wild-type cases show obvious benefit. In this study, we demonstrated that progesterone acted synergistically with niraparib cancer cells by enhancing niraparib-mediated DNA damage death regardless status. This synergy was validated an organoid model vivo experiments....