A5075671474- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Immune Response and Inflammation
- Epigenetics and DNA Methylation
- Organ Transplantation Techniques and Outcomes
- Cancer-related gene regulation
- Cell death mechanisms and regulation
- Lung Cancer Diagnosis and Treatment
- RNA Research and Splicing
- Bone Metabolism and Diseases
- Lung Cancer Research Studies
- Acute Kidney Injury Research
- Probiotics and Fermented Foods
- Bone health and treatments
- Eicosanoids and Hypertension Pharmacology
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
Hunan Cancer Hospital
2019-2024
Central South University
2019-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
Singapore General Hospital
2024
German Cancer Research Center
2021-2024
Heidelberg University
2021-2024
University Hospital Heidelberg
2021-2024
Hebei Medical University
2024
Shanghai Sunshine Rehabilitation Center
2023-2024
Nanjing University of Chinese Medicine
2024
IntroductionRecent studies have indicated that the presence of ground-glass opacity (GGO) components is associated with favorable survival. The purpose this study was to reveal prognostic value GGO and differences in factors for part-solid solid lesions invasive stage I NSCLC.MethodsThe cases 2010 patients completely resected pathological NSCLC were reviewed according eighth edition TNM classification. Patients categorized into pure-GGO, part-solid, groups based on consolidation-to-tumor...
Abstract Background The epithelial-mesenchymal transition (EMT) is crucial for metastasis and positively regulated by calcium-related signaling. melastatin-related transient receptor potential 7 (TRPM7) regulates a non-selective cation channel promotes cancer metastasis. However, the mechanisms underlying action of TRPM7 in ovarian are unclear. Methods expression EMT markers (Vimentin, N-cadherin, Twist E-cadherin) samples was detected. TRPM7was knockdown shRNA Ovarian cell lines to examine...
Abstract Triple-negative breast cancer (TNBC) cells are in a more hypoxic and starved state than non-TNBC cells, which makes TNBC always maintain high autophagy levels. Emerging evidence has demonstrated that circular RNAs (circRNAs) involved the progress of tumorigenesis. However, regulation functions autophagy-induced circRNAs remain unclear. In our study, autophagy-responsive circRNA candidates under amino acid were identified by RNA sequencing. The results showed circEGFR expression was...
Circular RNAs (circRNAs) were recently reported to be involved in the pathogenesis of ovarian cancer (OC); however, molecular mechanisms circRNAs tumor progression and paclitaxel (PTX) resistance OC remain largely undetermined. Here, we focused on circTNPO3 (hsa_circ_0001741), which is located chromosome 7 (chr7): 128655032–128658211 derived from TNPO3 gene, thus termed as circTNPO3. By microarray qRT-PCR identified dramatically high expressed samples correlated with PTX resistance....
Abstract Pulmonary fibrosis (PF) is a progressive and fatal interstitial lung disease with limited therapeutic options at present, epithelial–mesenchymal transition (EMT) recognized as major cause of fibrosis. Our previous work has confirmed that total extract Anemarrhena asphodeloides Bunge [Asparagaceae] exerted the effect anti‐PF. As main constituent [Asparagaceae], timosaponin BII (TS BII) on drug‐induced EMT process in PF animals alveolar epithelial cells remains unknown. In this study,...
Erythropoietin (EPO) has been well recognized as a tissue protective agent by inhibiting apoptosis and inflammation. The effect of EPO, however, only occurs at high dosage, which may elicit severe side-effects the meantime. Helix B surface peptide (HBSP), novel derived from non-erythropoietic helix plays specific role in protection. We investigated effects HBSP expression its heterodimeric receptor, beta common receptor (βcR)/EPO (), murine renal ischemia reperfusion (IR) injury model....
c-Met has been shown to promote organ development and cancer progression in many cancers. However, clinicopathological prognostic value of breast remains elusive.PubMed EMBASE databases were searched for eligible studies. Correlation overexpression with survival data features was analyzed by using hazard ratio (HR) or odds (OR) fixed-effect random-effect model according heterogeneity. All statistical tests two-sided.32 studies 8281 patients total. The related poor OS (overall survival)...
Background: Chemotherapy resistance is a significant cause for poor prognosis of epithelial ovarian cancer (EOC). However, the molecular mechanism chemo-resistance remains unclear, and developing available therapies effective biomarkers resistant EOC in urgent demand. Stemness cells directly results chemo-resistance. Exosomal miRNAs rebuild tumor microenvironment (TME) act as widely used clinical liquid biopsy markers. Methods: In our study, high throughput screenings comprehensive analysis...
The study was designed to investigate the chemical composition and antioxidant activities of polysaccharides from Yingshan Cloud Mist Tea. green tea (GTPS) analyzed by Fourier-transform infrared (FT-IR) spectroscopy, scanning electron microscope (SEM), thermogravimetric (TGA), gas chromatograph (GC), high-performance gel-permeation chromatography (HPGPC). Then, in vitro GTPS, effects GTPS on body weight, chickens were studied. results showed that composed rhamnose (Rha), arabinose (Ara),...
The characterization of CD4+ T-cell subsets reflects the immune status and is important in maintenance tumorigenesis homeostasis. To identify changes balance T helper (Th)1, Th2, Th17 regulatory cells (Treg) individuals with renal cell carcinoma (RCC), present study investigated a total 131 patients RCC 36 healthy volunteers. number T‑bet+ cells, GATA binding protein 3+ RAR-related orphan receptor γt+ CD25hi CD127lo CD45RA‑ CD45RA+ defined as Th1, Th17, activated naïve Treg respectively,...
Background. The majority of primary liver cancers in adults worldwide are hepatocellular carcinomas (HCCs, or hepatomas). Thus, a deep understanding the underlying mechanisms for pathogenesis and carcinogenesis HCC at molecular level could facilitate development novel early diagnostic therapeutic treatments to improve approaches prognosis patients. Our study elucidates HBV-HCC progression identifies important genes related diagnosis, tumour stage, poor outcomes HCC. Methods. GSE55092...
Globally, among all women, the most frequently detected and diagnosed lethal type of cancer is breast (BC). In particular, bone one frequent distant metastases 24in patients metastasis arises in approximately 80% advanced patients. Thus, we need to identify validate early detection markers that can differentiate from non-metastasis cancers.GSE55715, GSE103357, GSE146661 gene expression profiling data were downloaded GEO database. There was 14 with samples 8 tissue samples. GEO2R used screen...
Diabetic osteoporosis exhibits heterogeneity at the molecular level. Ferroptosis, a controlled form of cell death brought on by buildup lipid peroxidation, contributes to onset and development several illnesses. The aim was explore subtypes associated with ferroptosis in diabetic level further elucidate potential mechanisms.Integrating CTD, GeneCards, FerrDb databases, microarray data GSE35958, we identified ferroptosis-related genes (FRGs) osteoporosis. We applied unsupervised cluster...