A5015786687- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Phytochemical Studies and Bioactivities
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pharmacological Effects of Natural Compounds
- Chromatography in Natural Products
- Ginseng Biological Effects and Applications
- Natural Antidiabetic Agents Studies
- Ginger and Zingiberaceae research
- Nitric Oxide and Endothelin Effects
- Autophagy in Disease and Therapy
- Lung Cancer Treatments and Mutations
- Eosinophilic Esophagitis
- Medicinal Plants and Bioactive Compounds
- Molecular Biology Techniques and Applications
- Plant tissue culture and regeneration
- Gut microbiota and health
- Alkaloids: synthesis and pharmacology
- Mangiferin and Mango Extracts
- Phytochemistry and biological activity of medicinal plants
- Phytochemistry and Bioactive Compounds
- Polysaccharides and Plant Cell Walls
- IL-33, ST2, and ILC Pathways
- Extracellular vesicles in disease
- Biological and pharmacological studies of plants
Wannan Medical College
2011-2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2021
China Pharmaceutical University
2016-2017
Abstract Pulmonary fibrosis (PF) is a progressive and fatal interstitial lung disease with limited therapeutic options at present, epithelial–mesenchymal transition (EMT) recognized as major cause of fibrosis. Our previous work has confirmed that total extract Anemarrhena asphodeloides Bunge [Asparagaceae] exerted the effect anti‐PF. As main constituent [Asparagaceae], timosaponin BII (TS BII) on drug‐induced EMT process in PF animals alveolar epithelial cells remains unknown. In this study,...
Abstract In this study, we investigated the protective effects of gastrodin (Gas) against homocysteine‐induced human umbilical vein endothelial cell (HUVEC) injury and role phosphoinositide 3‐kinase (PI3K)/threonine kinase 1 (Akt)/endothelial nitric oxide synthase (eNOS) NF‐E2‐related factor 2 (Nrf2)/antioxidant response element (ARE) pathways. We stimulated cells with homocysteine (1 mmol/L, 24 hours) tested (200‐800 μg/mL) on viability production malondialdehyde (MDA), lactate...
Abstract Corydalis yanhusuo W.T. Wang is a classic herb that frequently used in traditional Chinese medicine and efficacious promoting blood circulation, enhancing energy, relieving pain. Benzylisoquinoline alkaloids (BIAs) are the main bioactive ingredients . However, few studies have investigated BIA biosynthetic pathway C. , of species-specific chemicals such as tetrahydropalmatine remains unclear. We performed full-length transcriptomic metabolomic analyses to identify candidate genes...
Exosome-miR-146a is significantly increased in patients with Atherosclerosis (AS), but its mechanism and effect on AS have not been fully elucidated.
Burdock roots are rich in inulin-type burdock fructooligosaccharide (BFO). However, the antidiabetic effect of BFO remains unknown. In this study, was purified using DEAE-52 and G-75. The purity 99.4%, peak-average molecular weight (Mp) 2958 Da. inhibited α-glucosidase activity with an IC50 0.4996 mg/mL. Streptozotocin (STZ) high-fat diet (HFD) induced diabetic mice were used to test anti BFO. reduced fasting blood glucose (FBG) levels, relieved rapid loss, improved tolerance after six weeks...
Ulcerative colitis (UC), as a chronic inflammatory disease, presents global public health threat. However, the mechanism of
The green and efficient preparation of natural products from biomass is considered an important area interest in pharmaceutical applications. In this study, we aimed to provide a practical example with popular traditional Chinese medicine, Anemarrhenae Rhizome, showcase the orthogonal use column chromatography polyamide macroporous adsorption resins selectively concentrate efficiently purify four bioactive compounds: neomangiferin (NMF), mangiferin (MF), timosaponin B‐II (TS B‐II), A‐III...
Key word: qPCR; Corydalisyanhusuo; reference genes; geNorm; NormFinder; BestKeeper.
Abstract Background Green and economic conversion of spirostanol saponins in the plant is considered as an attracting area pharmaceutical applications. We aimed to provide a practical paradigm named limewater-based (LCSS), meanwhile, widely-used traditional Chinese herbal medicine, Paridis Rhizoma (PR), was selected case study. Methods Based on single factor experiments, response surface methodology (RSM) using Box-Behnken design (BBD) employed optimize processing time, limewater...
Clinopodii herba is a folk herbal medicine for treatments of hemorrhagic disorders. However, there not even quantitative standard clinopodii deposited in the Chinese Pharmacopoeia. The development strategy rapid and efficient extraction simultaneous detection multiple components therefore great value its quality evaluation. Here, variable wavelength was firstly applied to quantity by segmental monitoring UHPLC with diode array detector following ultrasound-assisted extraction. parameters...