A5100391868- Cellular Mechanics and Interactions
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Electrospun Nanofibers in Biomedical Applications
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Advanced Sensor and Energy Harvesting Materials
- Muscle Physiology and Disorders
- Nerve injury and regeneration
- Cell Adhesion Molecules Research
- Tissue Engineering and Regenerative Medicine
- Graphene and Nanomaterials Applications
- Glioma Diagnosis and Treatment
- Signaling Pathways in Disease
- Silk-based biomaterials and applications
- Bone Tissue Engineering Materials
- RNA Research and Splicing
- Knee injuries and reconstruction techniques
- Cardiac tumors and thrombi
- Wnt/β-catenin signaling in development and cancer
- Hydrogels: synthesis, properties, applications
- Bone and Joint Diseases
- Vascular Tumors and Angiosarcomas
Jinzhou Medical University
2025
Beijing University of Chinese Medicine
2024
Guangzhou University of Chinese Medicine
2023-2024
Universidade de Vigo
2024
Hunan University of Traditional Chinese Medicine
2024
Soochow University
2024
First Affiliated Hospital of Soochow University
2024
China Pharmaceutical University
2024
Agency for Science, Technology and Research
2024
Singapore Institute of Manufacturing Technology
2024
During the traumatic brain injury (TBI), improved expression of circulatory miR-21 serves as a diagnostic feature. Low levels exosome-miR-21 in can effectively improve neuroinflammation and blood-brain barrier (BBB) permeability, reduce nerve apoptosis, restore neural function ameliorate TBI. We evaluated role macrophage derived exosomes-miR-21 (M-Exos-miR-21) disrupting BBB, deteriorating TBI, Rg1 interventions. IL-1β-induced macrophages (IIM)-Exos-miR-21 activate NF-κB signaling pathway...
Abstract Ischemic stroke is a dreadful vascular disorder that poses enormous threats to the public health. Due its complicated pathophysiological features, current treatment options after ischemic attack remains unsatisfactory. Insufficient drug delivery lesions impeded by blood–brain barrier (BBB) largely limits therapeutic efficacy of most anti‐stroke agents. Herein, inspired rapid BBB penetrability 4T1 tumor cells upon their brain metastasis and natural roles platelet in targeting injured...
Abstract We have constructed a chitosan nonwoven nanofiber mesh tube consisting of oriented fibers by the electrospinning method. The efficacy nanofibers on Schwann cell alignment and positive effect this peripheral nerve regeneration were confirmed. physical properties sheets prepared with or without fiber orientation characterized. Then, immortalized cells cultured these sheets. Furthermore, tubes orientation, bilayered an inner layer outer randomized bridgegrafted into rat sciatic defect....
Abstract: Exosomes, small extracellular vesicles derived from cells, are known to carry important bioactive molecules such as proteins, nucleic acids, and lipids. These components play crucial roles in cell signaling, immune response, tumor metastasis, making exosomes potential diagnostic biomarkers for various diseases. However, current methods detecting face scientific challenges including low sensitivity, poor specificity, complicated procedures, high costs. It is essential surmount these...
Abstract Extracellular vesicles (EVs) derived from differentiating induced stem cells maintain their original stemness and trends possess strong immunoregulatory capability. Biomaterials equipped with EVs are very promising in regenerative medicine. However, surface EV‐decoration on osteoimplants remains a challenge, due to the complexity of traditional molecular conjugations fragility EVs. Here, mussel‐like adhesion is combined bioorthogonal click conjugation introduce titanium (Ti)...
Regulation of the actin-myosin cytoskeleton plays a central role in cell migration and cancer progression. Here, we report discovery cytoskeleton-associated kinase, pseudopodium-enriched atypical kinase 1 (PEAK1). PEAK1 is 190-kDa nonreceptor tyrosine that localizes to actin filaments focal adhesions. undergoes Src-induced phosphorylation, regulates p130Cas-Crk-paxillin Erk signaling pathways, operates downstream integrin epidermal growth factor receptors (EGFR) control spreading, migration,...
Cell-free RNAs and extracellular vesicles (EVs) are valuable biomarkers in liquid biopsies, but they prone to preanalytical variabilities such as nonstandardized centrifugation or ex vivo blood degradation. Herein, we report a high-throughput label-free inertial microfluidic device (ExoArc) for isolation of platelet-free plasma from RNA EV analysis. Unlike conventional devices widely used cell sorting, submicrometer size cutoff (500 nm) was achieved which completely removed all leukocytes,...
Abstract We have developed a novel bilayered chitosan tube that comprises an outer layer of film and inner nonwoven nano/microfiber mesh. The is fabricated with electrospinning method. characterized the microstructure mechanical properties this material. introduced glycine spacers into C YIGSR sequence, domain laminin‐1 enhances Schwann cells migration attachment, as well neural outgrowth, resulting in amino acid sequences CGG CGGGGGG . These peptides were covalently bound to mesh surface...
For the treatment of glioma and other central nervous system diseases, one biggest challenges is that most therapeutic drugs cannot be delivered to brain tumor tissue due blood-brain barrier (BBB). The goal this study was construct a nanodelivery vehicle with capabilities overcome BBB for administration. Doxorubicin as model drug encapsulated in ganglioside GM1 micelles able achieve up 9.33% loading efficiency 97.05% encapsulation by orthogonal experimental design. vitro demonstrated slow...
Background: Small extracellular vesicles (sEVs) obtained from human umbilical cord mesenchymal stromal cells (MSCs) have shown cardioprotective efficacy in doxorubicin-induced cardiotoxicity (DIC). However, their clinical application is limited due to the low yield and high consumption. This study aims achieve large-scale production of sEVs using a three-dimensional (3D) bioreactor system. In addition, were developed deliver Ginsenoside Rg1 (Rg1), compound derived traditional Chinese...
Exosome-miR-146a is significantly increased in patients with Atherosclerosis (AS), but its mechanism and effect on AS have not been fully elucidated.
Abstract The healing of bone defects among diabetic patients presents a critical challenge due to the pathological microenvironment, characterized by hyperglycemia, excessive reactive oxygen species (ROS) production, and inflammation. Herein, multifunctional composite microspheres, termed GMAP are developed, using microfluidic technique incorporating Au@Pt nanoparticles (NPs) GelMA hydrogel modulate microenvironment for promoting regeneration. enables sustained release NPs, which function as...
Meniscus injury is one of the most common knee diseases, which managed through conservative and surgical treatments. In recent years, biotherapy has shown great potential to treat various symptoms caused by meniscus repair. Human amniotic epithelial cells (hAECs), are easy acquire, non-tumorigenic, high tri-lineage differentiation potential, a promising cell source for tissue engineering applications. Studies have demonstrated that Transforming Growth Factor-β3 (TGF-β3) can facilitate...
Abstract Numerous studies have shown that calmodulin (CaM) is a major regulator of calcium-dependent signaling, which regulates cell proliferation, programmed death, and autophagy in cancer. However, limited information available on mechanisms underlying the effect CaM invasive property glioblastoma multiforme (GBM) cells, especially with respect to invadopodia formation. In this study, we find serves as prognostic factor for GBM, it strongly associated nature tumor. Results preliminary...
The contractile activity of muscle cells lining the walls collecting lymphatics is responsible for generating and regulating flow within lymphatic system. Activation PKC signaling contributes to regulation smooth contraction by enhancing sensitivity apparatus Ca 2+ . It currently unknown whether contraction. We hypothesized that activation would increase myofilament To test this hypothesis, we determined effects with phorbol esters [PMA or dibutyrate (PDBu)] on behavior α-toxin-permeabilized...
With the ever-growing concern about environmental conservation, green production and water-based nanofibers have attracted more interest from both academic industrial fields; nevertheless, stabilization process of is primarily relying on application organic solvent-based crosslinking agents. In this work, we develop a approach to fabricate water-resistant polyvinyl alcohol (PVA) by using epoxy compound, N1, N6-bis(oxiran-2-ylmethyl) hexane-1,6-diamine (EH), as crosslinker. This EH/sodium...