A5028280817- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Chemokine receptors and signaling
- Microtubule and mitosis dynamics
- Cancer Mechanisms and Therapy
- Signaling Pathways in Disease
- Autophagy in Disease and Therapy
- Medicinal Plant Pharmacodynamics Research
- Cellular Mechanics and Interactions
- Advanced ceramic materials synthesis
- Ubiquitin and proteasome pathways
- Ion Transport and Channel Regulation
- Auction Theory and Applications
- Cytokine Signaling Pathways and Interactions
- PI3K/AKT/mTOR signaling in cancer
- RNA Research and Splicing
- Galectins and Cancer Biology
- Metal and Thin Film Mechanics
- Innovation Diffusion and Forecasting
- MXene and MAX Phase Materials
- Advanced Photocatalysis Techniques
- Pharmaceutical and Antibiotic Environmental Impacts
Henan Normal University
2023-2024
Tianjin Medical University General Hospital
2017-2022
Dalian Maritime University
2022
Beijing Institute of Technology
2021
Ministry of Education of the People's Republic of China
2018
Nanjing Agricultural University
2017
Glioma initiating cells (GICs), also known as glioma stem (GSCs), play an important role in the progression and recurrence of glioblastoma multiforme (GBM) due to their potential for self-renewal, multiple differentiation tumor initiation. In recent years, Notch1 has been found be overexpressed GICs. However, regulatory mechanism self-renewal invasion ability GICs remains unclear. This study aims explore effect Notch pathway on underlying mechanisms. Bioinformatic analysis...
ACT001, which is derived from an ancient anti-inflammatory drug, has been shown to cross the blood-brain barrier in preclinical studies and demonstrated anti-glioblastoma (GBM) activity clinical trials. However, its pharmacological potential for anti-GBM immune response modulation remains unclear. The chemical structure of ACT001 indicates that it may bind STAT3 thus modulate antitumor response. Methods: Bioinformatics immunohistochemistry (IHC) were used assess PD-L1 expression gliomas....
Autophagy is a vital process that involves degradation of long-lived proteins and dysfunctional organelles contributes to cellular metabolism. Glioma-initiating cells (GICs) have the ability self-renew, differentiate into heterogeneous types tumor cells, sustain tumorigenicity; thus, GICs lead recurrence. Accumulating evidence indicates autophagy can induce stem cell differentiation increase lethality temozolomide against GICs. However, mechanism underlying regulation GIC self-renewal by...
Abstract In recent years, research on glioma immunotherapy have grown rapidly. However, the autoimmune‐like side effects that are caused by blocking immunological checkpoints hinder their clinical application in gliomas currently. Galectin‐9, a ligand for T‐cell immunoglobulin mucin 3, has shed new light treatment of malignant glioma. potential mechanism Galectin‐9 is still under discussion. this study, first, we methodically gathered 1,027 patients with RNA‐seq and 986 survival data to...
Glioblastoma is the most common and lethal primary intracranial tumor. As key regulator of tumor cell volume, sodium‐potassium‐chloride cotransporter 1 (NKCC1) expression increases along with malignancy glioma, NKCC1 has been implicated in glioblastoma invasion. However, little known about role epithelial‐mesenchymal transition‐like process gliomas. We noticed that aberrantly elevated leads to changes shape, polarity, adhesion cells glioma. Here, we investigated whether promotes an...
Abstract Numerous studies have shown that calmodulin (CaM) is a major regulator of calcium-dependent signaling, which regulates cell proliferation, programmed death, and autophagy in cancer. However, limited information available on mechanisms underlying the effect CaM invasive property glioblastoma multiforme (GBM) cells, especially with respect to invadopodia formation. In this study, we find serves as prognostic factor for GBM, it strongly associated nature tumor. Results preliminary...
Abstract As one of the most popular forms social e‐commerce, group‐buying price (GBP) is a widely used pricing mechanism. One typical example PinDuoDuo, which was listed on NASDAQ stock exchange in 2018. On PinDuoDuo app, sellers generally encourage informed buyers to share information about products with uninformed increase sales volume. However, growing number have begun using new methods (e.g., online live streaming) themselves. In this article, we investigate optimal decisions under...
Glioblastoma (GBM) invasion and migration are key biological behaviors leading to refractoriness current therapies infiltration into the non‑tumor brain parenchyma. GBM cell is strongly dependent on tumor architecture in vivo, which absent traditional two‑dimensional (2D) monolayer culture. The present study applied a three‑dimensional (3D) hydrogel model rebuild vitro. Treatment with NSC23766, specific inhibitor of Ras‑related C3 botulinum toxin substrate 1 (Rac1), inhibited mesenchymal...
Background/Aims: Jagged1 is the ligands of Notch signaling and has been shown to promote glioma-initiating cells (GICs) in glioblastoma. The role GICs invasion underlying molecular mechanisms remain unclear. Methods: Survival data from R2 genomics analysis, Cancer Genome Atlas (TCGA), Chinese Glioma (CGGA) visualization platform database were used evaluate effects on overall patient survival. we investigated induced cells’ by matrix degradation assays Transwell cell vitro, then further...
Ca2+ release-activated channels (CRAC) are the main entry pathway regulating intracellular concentration in a variety of cancer types. Orai2 is pore-forming subunit CRAC central neurons. To explore role glioblastoma (GBM), we investigated key pathways and genes Orai2-mediated GBM by bioinformatic analyses. Via The Cancer Genome Atlas (TCGA), French, Sun, Gene Expression Omnibus (GEO) (GDS3885) datasets, collected 1231 cases with RNA-seq data analyzed functional annotation gene ontology (GO)...
Glioblastoma multiforme (GBM) is one of the most lethal types tumour, despite severe treatment methods. The Cancer Genome Atlas has categorised GBMs into proneural, neural, classical and mesenchymal subtypes; subgroup worst prognosis. CXCR4 been reported as selectively overexpressed in subtype positively associated with MES markers. However, to best our knowledge underlying mechanisms regarding how may regulate GBM are still unknown. present study aimed investigate critical pathways mediated...
Circular RNA is emerging functional molecule for glioblastoma. However, the function and regulatory of circular (circRNA) remains unclear. In this study, circRNA sequencing array data glioblastoma were analyzed by multiple bioinformatics methods to establish a potential molecular sponge mechanism regulation network.Gene Expression Omnibus datasets used extract circRNAs. CircInteractome was predict microRNAs binding Chinese Glioma Gene Atlas database screen with expression survival trends....
Aim: We aimed at investigating the mechanism of RAB1A proliferation and invasion in gliomas. Materials & methods: Genome-wide expression profile data immunohistochemistry were analyzed to assess The Transwell assay, wound healing brain slice coculture model, cellular fluorescence intracranial xenograft model nude mice used determine glioma cells. Results conclusion:RAB1A was highly expressed gliomas compared with normal tissue. overall survival time patients high significantly shortened....
Aims Modified bagasse-based mesoporous carbons were prepared for the efficient chromium(III) ion adsorption and removal from aqueous solutions. Methods Mesoporous bagasse with H3PO4 activation subsequently oxidized nitric acid modified ethylenediamine. Results The results showed that carbon was rich in mesopores, oxygen nitrogen-containing groups, Cr(III) capacity greatly improved after modification, which found to be higher than both pristine carbons. on significantly influenced by solution...
Na+ -K+ -2Cl- cotransporter 1 (NKCC1) is highly expressed in malignant gliomas, which closely related to the degree of malignancy. NKCC1 protein has a vital function volume regulation glioma cells. allows cells transform its freely, migrating through narrow extracellular space achieve distant metastases. There also close relationship between and tumor cytoskeleton regulation. In addition, associated with cell cycle, nerve activity other biological functions. conclusion, plays an important...
Objective To investigate Calmodulin (CaM) antagonist N- (6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) inhibits invasion and migration of Glioblastoma (GBM) cells by reversing Epithelial-to-mesenchymal like transition (EMT-like). Methods The effect W-7 on the survival viability U87/U251MG was detected cell counting kit-8 (CCK-8) kit. Transwell assay used to detect number U87 U251 passing through basement membrane control treated groups. relative wound space in each group...
Objective To investigate the regulating mechanism of Notch1 signaling pathway on invasion and migration glioma initiating cells (GICs). Methods (1) Box-plotting was conducted to analyze mRNA expression in normal brain tissue glioblastoma using Bredel Brain, Sun Brain TCGA databases; Kaplan-Meier survival analysis association between prognosis patients with Hes1 database; Heatmap CXCR4 GICs common cell line GEO database. (2) Magnetic activated sorting adopted establish lines U87 U251...
Objective To investigate the effect of autophagy inducer AZD8055 on expression Notch pathway-related proteins and neurosphere formation in U87 initiating cells. Methods CD133-positive glioma cells were isolated using magnetic activated cell sorting method. The stem markers (CD133 Nestin) related (LC3B p62) identified via immunofluorescence analysis neurospheres glioma-initiating (GICs). survival viability was detected CCK8 kit. Notch1, intracellular domain, Hes1, p62, LC3B observed...