A5040818937- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Immune cells in cancer
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Signaling Pathways in Disease
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Medicinal Plant Pharmacodynamics Research
- Cancer Mechanisms and Therapy
- interferon and immune responses
- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- CAR-T cell therapy research
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- Lung Cancer Research Studies
- Cellular Mechanics and Interactions
- Cytokine Signaling Pathways and Interactions
- Drug Transport and Resistance Mechanisms
- Caveolin-1 and cellular processes
- Cancer, Stress, Anesthesia, and Immune Response
- ATP Synthase and ATPases Research
First Affiliated Hospital Zhejiang University
2020-2025
Zhejiang University
2021-2024
Johns Hopkins University
2020-2021
Johns Hopkins Medicine
2020-2021
Tianjin Medical University General Hospital
2016-2020
Tianjin Medical University
2016-2020
The First People's Hospital of Wenling
2020
Oxford University Press (United Kingdom)
2020
Ministry of Education of the People's Republic of China
2018
Glioma initiating cells (GICs), also known as glioma stem (GSCs), play an important role in the progression and recurrence of glioblastoma multiforme (GBM) due to their potential for self-renewal, multiple differentiation tumor initiation. In recent years, Notch1 has been found be overexpressed GICs. However, regulatory mechanism self-renewal invasion ability GICs remains unclear. This study aims explore effect Notch pathway on underlying mechanisms. Bioinformatic analysis...
ACT001, which is derived from an ancient anti-inflammatory drug, has been shown to cross the blood-brain barrier in preclinical studies and demonstrated anti-glioblastoma (GBM) activity clinical trials. However, its pharmacological potential for anti-GBM immune response modulation remains unclear. The chemical structure of ACT001 indicates that it may bind STAT3 thus modulate antitumor response. Methods: Bioinformatics immunohistochemistry (IHC) were used assess PD-L1 expression gliomas....
Abstract Glioblastoma is the most common primary intracranial malignant tumor in adults and has high morbidity mortality. TMEM158 been reported to promote progression of solid tumors. However, its potential role glioma still unclear. Here, we found that expression human cells core was significantly higher than noncancerous at edge using bioinformatics analysis. Cancer patients with GBMs harbored those WHO grade II or III gliomas. Interestingly, regardless grading, samples were IDH1-wild-type...
Autophagy is a vital process that involves degradation of long-lived proteins and dysfunctional organelles contributes to cellular metabolism. Glioma-initiating cells (GICs) have the ability self-renew, differentiate into heterogeneous types tumor cells, sustain tumorigenicity; thus, GICs lead recurrence. Accumulating evidence indicates autophagy can induce stem cell differentiation increase lethality temozolomide against GICs. However, mechanism underlying regulation GIC self-renewal by...
Clinical trials involving anti-programmed cell death protein-1 (anti-PD-1) failed to demonstrate improved overall survival in glioblastoma (GBM) patients. This may be due the expression of alternative checkpoints such as B- and T- lymphocyte attenuator (BTLA) on several immune types including regulatory T cells. Murine GBM models indicate that there is significant upregulation BTLA tumor microenvironment (TME) with associated exhaustion. We investigate use antibodies against PD-1 reversing...
Abstract In recent years, research on glioma immunotherapy have grown rapidly. However, the autoimmune‐like side effects that are caused by blocking immunological checkpoints hinder their clinical application in gliomas currently. Galectin‐9, a ligand for T‐cell immunoglobulin mucin 3, has shed new light treatment of malignant glioma. potential mechanism Galectin‐9 is still under discussion. this study, first, we methodically gathered 1,027 patients with RNA‐seq and 986 survival data to...
ABSTRACT Background Cancer‐associated fibroblasts (CAF) represent significant constituents within the extracellular matrix (ECM) across a range of cancers. Nevertheless, there exists scarcity direct proof concerning function CAF in glioblastoma (GBM). Aims This study endeavors to probe participation GBM by developing and validating CAF‐risk signature exploring its correlation with immune infiltration immunotherapy responsiveness. Methods Results To fulfill these objectives, mRNA expression...
Glioblastoma is the most common and lethal primary intracranial tumor. As key regulator of tumor cell volume, sodium‐potassium‐chloride cotransporter 1 (NKCC1) expression increases along with malignancy glioma, NKCC1 has been implicated in glioblastoma invasion. However, little known about role epithelial‐mesenchymal transition‐like process gliomas. We noticed that aberrantly elevated leads to changes shape, polarity, adhesion cells glioma. Here, we investigated whether promotes an...
Abstract Numerous studies have shown that calmodulin (CaM) is a major regulator of calcium-dependent signaling, which regulates cell proliferation, programmed death, and autophagy in cancer. However, limited information available on mechanisms underlying the effect CaM invasive property glioblastoma multiforme (GBM) cells, especially with respect to invadopodia formation. In this study, we find serves as prognostic factor for GBM, it strongly associated nature tumor. Results preliminary...
Glioblastoma (GBM) invasion and migration are key biological behaviors leading to refractoriness current therapies infiltration into the non‑tumor brain parenchyma. GBM cell is strongly dependent on tumor architecture in vivo, which absent traditional two‑dimensional (2D) monolayer culture. The present study applied a three‑dimensional (3D) hydrogel model rebuild vitro. Treatment with NSC23766, specific inhibitor of Ras‑related C3 botulinum toxin substrate 1 (Rac1), inhibited mesenchymal...
Glioma is the most common primary intracranial tumor and associated with poor prognosis. Identifying effective biomarkers for glioma particularly important. MXRA5, a secreted glycoprotein, involved in cell adhesion extracellular matrix remodeling has been reported to be expressed many cancers. However, role mechanism of action MXRA5 gliomas remain unclear. This study was aimed at investigating transcriptome level its clinical prognostic value. In this study, RNA microarray data 301 patients...
Abstract The tumor immunosuppressive microenvironment (IME) significantly affects occurrence, progression, and prognosis, but the underlying molecular mechanisms remain to make known. We investigated prognostic significance of PDPN its role in IME glioma. Weighted gene co-expression network analysis (WGCNA) found closely related IDH wildtype status higher immune score. Correlation suggested was highly positively relevant checkpoints expression block responding status. together with...
Background/Aims: Jagged1 is the ligands of Notch signaling and has been shown to promote glioma-initiating cells (GICs) in glioblastoma. The role GICs invasion underlying molecular mechanisms remain unclear. Methods: Survival data from R2 genomics analysis, Cancer Genome Atlas (TCGA), Chinese Glioma (CGGA) visualization platform database were used evaluate effects on overall patient survival. we investigated induced cells’ by matrix degradation assays Transwell cell vitro, then further...
Immune checkpoint inhibitors such as anti-programmed cell death protein 1 (anti-PD-1) have shown promise for the treatment of cancers melanoma, but results glioblastoma (GBM) been disappointing thus far. It has suggested that GBM multiple mechanisms immunosuppression, indicating a need combinatorial strategies. is well understood increases glutamate in tumor microenvironment (TME); however, significance this not understood. The authors posit upregulation TME immunosuppressive. utilized novel...
Ca2+ release-activated channels (CRAC) are the main entry pathway regulating intracellular concentration in a variety of cancer types. Orai2 is pore-forming subunit CRAC central neurons. To explore role glioblastoma (GBM), we investigated key pathways and genes Orai2-mediated GBM by bioinformatic analyses. Via The Cancer Genome Atlas (TCGA), French, Sun, Gene Expression Omnibus (GEO) (GDS3885) datasets, collected 1231 cases with RNA-seq data analyzed functional annotation gene ontology (GO)...
Glioblastoma multiforme (GBM) is one of the most lethal types tumour, despite severe treatment methods. The Cancer Genome Atlas has categorised GBMs into proneural, neural, classical and mesenchymal subtypes; subgroup worst prognosis. CXCR4 been reported as selectively overexpressed in subtype positively associated with MES markers. However, to best our knowledge underlying mechanisms regarding how may regulate GBM are still unknown. present study aimed investigate critical pathways mediated...
Abstract Gamma knife radiosurgery (GKRS) is recommended as the first-line treatment for brain metastases of lung adenocarcinoma (LUAD) in many guidelines, but its specific mechanism unclear. We aimed to study changes proteome LUAD response hyperacute phase GKRS and further explore differentially expressed proteins (DEPs). Cancer tissues were collected from a clinical trial neoadjuvant stereotactic before surgical resection large (ChiCTR2000038995). Five metastasis within 24 h after GKRS....
Abstract Background Glioma is a deadly and immunosuppressive brain tumour. Complement C1r subcomponent like ( C1RL ), prognostic biomarker in several kinds of tumours, has attracted increasing attention from oncologists. However, the role glioma remains unclear. Methods Through analysis 2120 patients 5 public datasets, relationships between expression clinicopathological characteristics were evaluated. Furthermore, -associated genes screened, Gene Ontology (GO) was conducted to investigate...
Introduction Despite the advent of immunotherapy as a promising therapeutic, glioblastoma (GBM) remains resistant to using checkpoint blockade due its highly immunosuppressive tumor milieu. Moreover, current anti-PD-1 treatment requires multiple infusions with adverse systemic effects. Therefore, we used PCL:PEG:PCL polymer gel loaded and implanted at site lymph nodes in an attempt maximize targeting inactivated T cells well mitigate unnecessary exposure.Methods Mice orthotopically GL261...
Abstract Inhibitor of nuclear factor kappa‐B kinase subunit epsilon (IKBKE) plays critical roles in the proliferation, invasion, and epithelial‐mesenchymal transition (EMT) glioblastoma (GBM). However, as an immune response factor, few studies have focused on role IKBKE glioblastoma‐mediated immunosuppressive microenvironment. Here, we found a higher expression level gliomas corresponding to malignancy tumor. The highest was examined core region GBM tissues well mesenchymal subtype, which...
INTRODUCTION: Despite the advent of immunotherapy as a promising therapeutic, glioblastoma (GBM) remains resistant to using checkpoint blockade against programmed cell death protein 1 (PD-1) on T cells. The highly immunosuppressive tumor milieu GBM prevents rescue inactivated cells due decreased numbers infiltrating at site well increased recruitment myeloid Moreover, current strategy antibodies PD-1 (anti-PD-1) requires multiple intravenous infusions every two or three weeks with...