A5083706310- Glioma Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Inflammation biomarkers and pathways
- Ion Channels and Receptors
- Inflammasome and immune disorders
- Medicinal Plants and Bioactive Compounds
- Cancer Mechanisms and Therapy
- Cytokine Signaling Pathways and Interactions
- Heme Oxygenase-1 and Carbon Monoxide
- Ultrasound in Clinical Applications
- Neuropeptides and Animal Physiology
- Cannabis and Cannabinoid Research
- Electrolyte and hormonal disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- MicroRNA in disease regulation
- S100 Proteins and Annexins
- Phonocardiography and Auscultation Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- COVID-19 diagnosis using AI
- Immune cells in cancer
- Intensive Care Unit Cognitive Disorders
- RNA Research and Splicing
- Autophagy in Disease and Therapy
Nanchong Central Hospital
2018-2024
Tianjin Medical University General Hospital
2022-2024
North Sichuan Medical University
2021-2024
Sepsis could lead to chronic cognitive impairment by unclear molecular mechanisms. Transient receptor potential melastatin-2 (TRPM2) is essential against immunity-related activities and inflammation. Our study attempted decipher the relationship between caused severe inflammation TRPM2 expression levels.
Ferroptosis is a form of programmed cell death (PCD) that has been implicated in cancer progression, although the specific mechanism not known. Here, we used latest DepMap release CRISPR data to identify essential ferroptosis-related genes (FRGs) glioma and their role patient outcomes.RNA-seq clinical information on cases were obtained from Chinese Glioma Genome Atlas (CGGA) The Cancer (TCGA). FRGs FerrDb database. CRISPR-screened (CSEGs) lines downloaded portal. A series bioinformatic...
Abstract The tumor immunosuppressive microenvironment (IME) significantly affects occurrence, progression, and prognosis, but the underlying molecular mechanisms remain to make known. We investigated prognostic significance of PDPN its role in IME glioma. Weighted gene co-expression network analysis (WGCNA) found closely related IDH wildtype status higher immune score. Correlation suggested was highly positively relevant checkpoints expression block responding status. together with...
Abstract Non-SMC (Structural Maintenance of Chromosomes) condensin I complex subunit H (NCAPH) has been shown to facilitate progression and predict adverse prognostic outcome in many cancer types. However, the function NCAPH gliomas is still unclear. Series experiments were taken uncover glioma. The expression potential mechanism regulating glioma was verified by bioinformatics analysis. Lentiviral transfection used for establishment loss-of-function gain-of-function cell lines. CCK-8 assay...
<title>Abstract</title> Glioblastoma, IDH-wildtype (GBM, WHO grade 4) is the most common and lethal type of brain cancer that hard to cure. Among 3 subtypes GBM, mesenchymal GBM characterized by therapeutic resistance poor outcomes. Here, we found both STAT3 NF-κB pathways are abnormally activated in patients with higher expression had a prognosis TCGA database. Using inhibitor, Stattic, suppress signaling cells. However, it was observed Stattic alone leads compensatory activation signaling....
Glioma is an intracranial tumor characterized by high mortality and recurrence rates. In the present study, association of TRPM8 channel-associated factor 2 (TCAF2) in glioma was investigated using bioinformatics, showing significant relationships with age, WHO grade, IDH, 1p/19q status, as well being independent predictor prognosis. Immunohistochemistry a sample microarray showed markedly increased TCAF2 expression glioblastoma relative to lower-grade glioma, elevated predominating center....
Abstract Background: Cognitive dysfunction after sepsis is the most serious complication discharge of patients, and its pathogenesis related to inflammation central nervous system caused by damaged blood-brain barrier. Interleukin-1β (IL-1β) a key factor in sepsis-induced cognitive mice. Several investigations have suggested that TRPM2 (transient receptor potential melastatin-2) performs vital task immune response inflammation. The aim this exploration was discover importance IL-1β apoptosis...
Knowledge of lung ultrasound characteristics coronavirus disease 2019 pneumonia might be useful for early diagnosis and clinical monitoring patients, can help to control the spread infection in healthcare settings. In this case report, a 36-year-old man with severe acute respiratory syndrome 2 was diagnosed by reverse transcription-polymerase chain reaction testing nasopharyngeal swab. The findings patient were interstitial-alveolar damage showing bilateral, diffuse pleural line...
Background: Ischemia/reperfusion (I/R)-induced stroke is a long-lasting disability. Numerous reports have demonstrated that inflammation the major cause of ischemic cerebral injury. Therefore, it important to develop an effective anti-inflammatory agent for attenuation I/R-induced brain Objective: In this study, we examined therapeutic role kirenol against neuronal damage by inhibiting in Sprague-Dawley (SD) rats. Materials and Methods: I/R was induced SD rats subsequently were administered...