Clinical trials involving anti-programmed cell death protein-1 (anti-PD-1) failed to demonstrate improved overall survival in glioblastoma (GBM) patients. This may be due the expression of alternative checkpoints such as B- and T- lymphocyte attenuator (BTLA) on several immune types including regulatory T cells. Murine GBM models indicate that there is significant upregulation BTLA tumor microenvironment (TME) with associated exhaustion. We investigate use antibodies against PD-1 reversing...

Purpose The aboutness (a subject matter of resource) information has been strongly emphasized when organizing and searching for different types media resources. For video games, mood is one the critical subjective elements that supports users in finding games interest. current study examines a previously developed game controlled vocabulary (CV) to empirically test its applicability evaluate individual terms’ separability distinctiveness. Design/methodology/approach research team collected...

Introduction. Readers’ advisory (RA) services are one of the core information that libraries provide. As types and formats collection materials have diversified, relevant RA evolved accordingly. This project develops an guide for webtoons, emerging online webcomics successfully engaged international audiences with their diverse themes accessible content. Methods. The current study compiled data from focus groups, semi-structured interviews, a large-scale survey avid webtoon readers. Then,...

User studies in the music information retrieval ( MIR ) domain tend to be exploratory and qualitative nature, involving a small number of users, which makes it difficult derive broader implications for system design. In order fill this gap, we conducted large‐scale user survey questioning various aspects people's needs behaviors. particular, investigated if general users' behaviors have significantly changed over time by comparing our current results with similar 2004. paper, present key...

Video games and interactive media are increasingly becoming important part of our culture everyday life, subsequently, archival digital library collections. However, existing organizational systems often use vague or inconsistent terms to describe video attempt schemas designed for textual bibliographic resources. Our research aims create a standardized metadata schema encoding scheme that provides an intelligent comprehensive way represent games. We conducted interviews with 24 gamers,...

Extensive production of recombinant protein is essential for use in various fields. Bacterial cells, especially the Escherichia coli (E. coli) expression system, are widely used proteins due to their advantages time and cost. However, formation inclusion bodies (IBs) caused by a significant issue. Therefore, precise tool detection IBs high demand. In this study, we demonstrated label-free rapid sensing platform E. using terahertz-time domain spectroscopy (THz-TDS) system terahertz...

The discovery and retrieval of video games in library information systems is, by large, dependent on a limited set descriptive metadata. Noticeably missing from this metadata are classifications visual style–despite the overwhelmingly nature most interest style among game users. One explanation for paucity is difficulty eliciting consistent judgements about style, likely due to subjective interpretations terminology lack demonstrable testing coinciding judgements. This study presents...

Purpose With ready access to search engines and social media platforms, the way people find image information has evolved diversified in past two decades. The purpose of this paper is provide an overview literature on needs behaviors. Design/methodology/approach Following eight-step procedure for conducting systematic reviews, presents analysis peer-reviewed work behaviors, with publications ranging from years 1997 2019. Findings Application inclusion criteria led 69 works. These works were...

Despite the increase in interest video games across commercial and academic areas, organizational systems for classifying them remain inadequate, particularly describing visual styles of games. Because are by large a medium, ability to describe their "look" coherently consistently greatly contributes discovery through classification. A set controlled terms would be instrumental complementing game recommendation engines search applications digital libraries meet users' content-related...

Public librarians across the United States found themselves in different political environments that challenged their ability to serve communities, provide information was needed, and fight disinformation regarding pandemic. Researchers at University of Missouri examined how what communicated public about COVID-19. A survey sent a systematic sample libraries from all states service-area sizes, carried out January 24 February 7, 2022. total 106 responses were received, with 66 respondents...

Video games reflect the current culture and society. Games stand as points of transmission that cultural trends social norms, although not comprehensively. While it seems more have tried to be inclusive diverse gender sexual identities recently, there is still a lack studies discuss how real video game players see LGBTQ+ games. To understand players’ perceptions in this regard, study qualitatively analyzes online review postings from Steam, focusing on user reviews sexuality Based four...

Despite their increasing popularity and inclusion in library collections, video games are rarely suggested advisory or recommendation services. In this work, we use the concept of appeals from existing literature readers’ media studies to understand what attracts people play certain games. Based on 1,257 survey responses, identify sixteen different elaborate how these expressed users’ terms. We envision can serve as an additional access point for will be particularly useful addition, also...

Despite the growing interests in video games as consumer products well objects of research, current methods for accessing are limited. We present Vizmo a new way browsing based on their visual style and mood. In order to test usability usefulness Vizmo, we asked 19 game experts evaluate interaction with tool. The results show that perceived novel aesthetically pleasing discovery tool which would be most useful research historical aesthetic aspects. discuss five key points improving design...

Purpose The purpose of this paper is to improve the understanding relevant information features for users seeking anime recommendations. Design/methodology/approach study uses content analysis 396 recommendation request threads from online forum at Anime News Network. Findings In total, 19 important were identified, including Work, Theme, Genre, Audience, Mood, while Artwork/Visual Style, Audio and Language mentioned less frequently. However, when mentioned, these codes discussed with...

Purpose Readers articulate mood in deeply subjective ways, yet the underlying structure of users' understanding media they consume has important implications for retrieval and access. User articulations might at first seem too idiosyncratic, but organizing them meaningfully considerable potential to provide a better searching experience all involved. The current study develops categories inductively fiction organization information systems. Design/methodology/approach authors developed...

ABSTRACT In the context of popular culture, a successful work or with broad cultural scientific impact often prompts publication many derivative works across multiple formats and by creators, that share elements original such as topics, characters universes. We argue for reconceputalization “Superwork” entity to aggregate these relevant into single bibliographic about which facts in form metadata, exploitable library users, can be recorded. this paper, we aim conduct deeper investigation...

Abstract To understand the roles of fiction reading in mitigating readers' stress during COVID‐19 pandemic, this study explores motivations, preferences, and behaviors. Through an open‐ended online survey posted on social media platforms community, researchers collected 76 responses from adult readers. qualitative coding, three prominent themes were identified: escapism, re‐reading behavior, access format. Readers actively escape into fictional worlds, often through books, to cope with...

KO KNOWLEDGE ORGANIZATION , Seite 484 - 499

Purpose Author information is one of the primary metadata elements for access. While assigning “author(s)” has been relatively straightforward in library systems textual resources, challenges have emerged recording creatorship collaborative creative works, with surrogates erring on side caution and providing little information. This study aims to present improvements conceptual understanding relevant cataloging practice video games. Design/methodology/approach The current a theoretical...

During the COVID-19 pandemic of 2020-2021, public library leaders across United States were forced to make decisions quickly that affected services and resources they able provide. However, health information had on was imperfect constantly changing. Interviews with 23 managers directors revealed more authoritative local data needed for decision-making share their service populations. Overwhelmed system and/or suspicious or skeptical political environments hindered access locally-specific...

Abstract Video game users have shown strong interests in having subject metadata to find games. However, creating and maintaining is costly difficult. This study explores the utility of an automated approach for generating video games, focusing on plot narrative. By comparing two methods analyze reviews—qualitative analysis conducted by a human researcher vs. text using topic modeling—the researchers investigate if method can generate terms that are comparable ones generated qualitative...

Despite the increasing consumption and popularity of audio-visual materials non-textual information, recommendation-based information retrieval research regarding these remains limited. To provide robust recommendation services to users, it is critical understand how users describe their needs when they seek audio- visual materials. We conducted a content analysis 396 threads from Anime News Network online forums identify 19 common features used in requests. Work, Theme, Genre were most...

Abstract This study investigates the readers of Korean webcomics, Webtoon, to understand their motivations for reading appeals and any informal learning experiences Webtoon encounter. adopts reader behavior theories media studies as two main theoretical foundations; within these frameworks, authors aim a hybrid platform, which has characteristics both multimedia conventional content. To experiences, focus group method was used. Findings show that include relaxation, emotional affirmation,...