A5100614084- Traditional Chinese Medicine Analysis
- Ferroptosis and cancer prognosis
- Angiogenesis and VEGF in Cancer
- Diabetic Foot Ulcer Assessment and Management
- Cancer-related molecular mechanisms research
- Atherosclerosis and Cardiovascular Diseases
- Wound Healing and Treatments
- Burkholderia infections and melioidosis
- Pregnancy and Medication Impact
- Salmonella and Campylobacter epidemiology
- Brucella: diagnosis, epidemiology, treatment
- Ovarian function and disorders
- Pressure Ulcer Prevention and Management
- Circular RNAs in diseases
- Cell Adhesion Molecules Research
- vaccines and immunoinformatics approaches
- Immunotherapy and Immune Responses
- TGF-β signaling in diseases
- Optical Systems and Laser Technology
- Barrier Structure and Function Studies
- IL-33, ST2, and ILC Pathways
- Gastrointestinal Bleeding Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Optical measurement and interference techniques
- Medicinal Plant Pharmacodynamics Research
Southern Medical University
1997-2024
Shanghai Academy of Agricultural Sciences
2024
Nanfang Hospital
1997-2024
Zhejiang Chinese Medical University
2024
Jilin University
2023-2024
Dalian Medical University
2023-2024
Second Affiliated Hospital of Dalian Medical University
2023-2024
Tibet Autonomous Region People's Hospital
2023-2024
Weatherford College
2024
First Affiliated Hospital of Dalian Medical University
2023
Ferroptosis, a new regulated cell death pathway, plays crucial part in the development of cardiovascular disease. However, precise underlying mechanism remains unclear. Therefore, this study aimed to elucidate this.Herein, an erastin-induced H9C2 ferroptosis vitro model and myocardial infarction murine model, which was created by ligating left anterior descending coronary artery, were established. Ferroptosis-related indicators, injury-related Nrf2 signaling-related proteins expression...
The burden of diabetic foot ulcers (DFU) is exacerbated in patients with concomitant arteriosclerotic occlusion disease (ASO) the lower extremities, who experience more severe symptoms and poorer prognoses. study aims to develop a predictive model grounded machine learning (ML) algorithms, specifically tailored forecast occurrence DFU extremity ASO. involves data from diagnosed ASO January 1, 2011 August 31, 2023. We conducted quality control on data. Subsequently, dataset was divided into...
Cardiovascular disease, a disease caused by many pathogenic factors, is one of the most common causes death worldwide, and oxidative stress plays major role in its pathophysiology. Tanshinone I (Tan I), natural compound with cardiovascular protective effects, main active compounds extracted from Salvia miltiorrhiza . Here, we investigated whether Tan could attenuate stress–induced cardiomyocyte apoptosis through Nrf2/MAPK signaling vivo vitro We found that treatment protected cardiomyocytes...
Users of the digital image correlation method are faced with problem poor operability, low repeatability, and lack standardized specifications for spraying speckles. To solve problem, research proposed a rock deformation measurement that obviates need to spray A local binary model was established by using pattern (LBP) operator based on deep texture features surfaces. The resulting LBP speckle can substitute artificial patterns demonstrates high quality strong applicability. Based pattern,...
Diabetic osteoporosis exhibits heterogeneity at the molecular level. Ferroptosis, a controlled form of cell death brought on by buildup lipid peroxidation, contributes to onset and development several illnesses. The aim was explore subtypes associated with ferroptosis in diabetic level further elucidate potential mechanisms.Integrating CTD, GeneCards, FerrDb databases, microarray data GSE35958, we identified ferroptosis-related genes (FRGs) osteoporosis. We applied unsupervised cluster...
Background In the realm of Gut-Brain axis research, existing evidence points to a complex bidirectional regulatory mechanism between gut microbiota and brain. However, question whether causal relationship exists specific types brain tumors, such as gliomas, remains unresolved. To address this gap, we employed publicly available Genome-Wide Association Study (GWAS) MIOBEN databases, conducting an in-depth analysis using Two-Sample Mendelian Randomization (MR). Method We carried out two sets...
The prevention of diabetic foot ulcers (DFU) precedes treatment, in that early significantly reduces the incidence ulcers. main objectives this study were to examine current prevalence proactive ulcer examinations among patients and analyze influencing factors, order provide a scientific reference for DFU patients. National Health Nutrition Examination Survey (NHANES) 2011-2018 (n = 1278) data utilized cross-sectional study. dependent variable was whether underwent self-initiated...
Atherosclerosis (AS) is an inflammatory disease, whose occurrence and development mechanism related to a great number of cytokines. β-sitosterol (BS), natural compound extracted from numerous vegetables plant medicines, has been suggested improve AS, but the underlying remains vague. This work focused on investigating how BS affected lipopolysaccharide (LPS)-treated human umbilical vein endothelial cells (HUVECs) further exploring potential targets mechanisms through network pharmacology...
BackgroundDiabetic foot ulcers (DFUs) are among the most prevalent and dangerous complications of diabetes. Angiogenesis is pivotal for wound healing; however, its role in chronic healing process DFU requires further investigation. We aimed to investigate pathogenic processes angiogenesis from a molecular biology standpoint offer insightful information about prevention therapy.MethodsDifferential gene weighted co-expression network analyses (WGCNA) were employed screen genes related using...
Studies have indicated that Vascular mimicry (VM) could contribute to the unfavorable prognosis of skin cutaneous melanoma (SKCM). Thus, objective this study was identify therapeutic targets associated with VM in SKCM and develop a novel prognostic model. Gene expression data from The Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) were utilized differentially expressed genes (DEGs). By intersecting these DEGs genes, we acquired VM-related specific SKCM, then identified...
Abstract Background: The prevention of diabetic foot ulcers (DFU) precedes treatment, in that early significantly reduces the incidence ulcers. main objectives this study were to investigate current status proactive examination for patients and analyze factors influencing them, order provide a scientific reference DFU patients. Methods: National Health Nutrition Examination Survey (NHANES) 2011-2018 (n=1278) data utilized cross-sectional study. dependent variable was presence or absence...
Abstract Background Diabetic foot ulcer (DFU) is a common chronic and serious complication that impairs patients' quality of life. The relationship between ferroptosis complications diabetes has attracted much attention in recent years. Here, this study aims to apply the gene expression profile dermal lymphatic endothelial cells (DLECs) build ceRNA network explore potential ferroptosis-related biomarkers pathways related molecular mechanism DFU. Methods GSE38396 dataset from Gene Expression...
Dieulafoy’s lesion is an uncommon but important cause of gastrointestinal bleeding, especially with respect to the upper tract wherein massive, life-threatening haemorrhage occurs from a calibre-persistent submucosal artery. This report describes case 60-year-old man gastric presenting exogastric haemorrhage, which was diagnosed following pathological examination.