A5072854149- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Palliative Care and End-of-Life Issues
- Cancer-related molecular mechanisms research
- Endometrial and Cervical Cancer Treatments
- Cancer survivorship and care
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Radiomics and Machine Learning in Medical Imaging
- FOXO transcription factor regulation
- GDF15 and Related Biomarkers
- Metabolism, Diabetes, and Cancer
- Drug Transport and Resistance Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Advanced Glycation End Products research
- Microstructure and mechanical properties
- Angiogenesis and VEGF in Cancer
- Immunotherapy and Immune Responses
- Nursing Diagnosis and Documentation
- Axon Guidance and Neuronal Signaling
- Religion, Spirituality, and Psychology
- Wnt/β-catenin signaling in development and cancer
- Patient Dignity and Privacy
- Colorectal and Anal Carcinomas
- Metal Alloys Wear and Properties
Central South University
2009-2024
Hangzhou Medical College
2023-2024
Zhejiang Provincial People's Hospital
2023-2024
Hunan Cancer Hospital
2019-2024
First Affiliated Hospital of Jinan University
2024
People's Hospital of Yangzhong
2024
University of Science and Technology of China
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Abstract Background Tumor cell metabolic reprogramming is crucial for the malignant behavior of cancer cells by promoting their proliferation. However, little known on how transient receptor potential 7 (TRPM7) modulates in ovarian cancer. Methods The effects TRPM7 silencing transcriptome profile, glucose uptake, lactic acid production, extracellular acidification rate (ECAR), oxygen consumption (OCR), intracellular ROS and ATP levels, NAD+/NADH ratios were examined. impacts levels...
Dysregulated long noncoding RNAs (lncRNAs) are potential markers of several tumor prognoses. This study aimed to develop a lncRNA expression signature that can predict chemotherapeutic sensitivity for patients with advanced stage and high-grade serous ovarian cancer (HGS-OvCa) treated platinum-based chemotherapy. The profiles 258 HGS-OvCa from Cancer Genome Atlas were analyzed. Results revealed an eight-lncRNA was significantly associated chemosensitivity in the multivariate logistic...
Circular RNAs (circRNAs) were recently reported to be involved in the pathogenesis of ovarian cancer (OC); however, molecular mechanisms circRNAs tumor progression and paclitaxel (PTX) resistance OC remain largely undetermined. Here, we focused on circTNPO3 (hsa_circ_0001741), which is located chromosome 7 (chr7): 128655032–128658211 derived from TNPO3 gene, thus termed as circTNPO3. By microarray qRT-PCR identified dramatically high expressed samples correlated with PTX resistance....
Abstract Background Nursing informatics (NI) competency is a required core for high-quality care in digitally enabled healthcare environments. Given the increasing reliance on digital health palliative settings, it becomes crucial to evaluate NI of nurses ensure seamless integration and effective utilization their clinical practice. This study aimed investigate level explore its associated factors among mainland China. Methods A cross-sectional design was conducted this study, involving...
Aims To explore the spiritual care competence among nurses in mainland China and determine its relationships with their self-efficacy personal characteristics. Backgrounds Nurses' perception of has critical effects on own practice. Having a view nurses' would help nurse managers recognize weakness Methods A descriptive cross-sectional study using online survey methods was carried out 2,970 Chinese nurses. Spiritual scale General Self-Efficacy Scale were used to collect data. Results The...
Accurate prediction of prognosis will help adjust or optimize the treatment cervical cancer and benefit patients. We aimed to investigate incremental value radiomics when added FIGO stage in predicting overall survival (OS) patients with cancer.This retrospective study included 106 (FIGO IB1-IVa) between October 2017 May 2019. Patients were randomly divided into a training cohort (n = 74) validation 32). All underwent contrast-enhanced computed tomography (CT) prior treatment. The ITK-SNAP...
Background: Solute Carrier Family 3 Member 2 (SLC3A2) is a member of the solute carrier family that plays pivotal roles in regulation intracellular calcium levels and transports L-type amino acids.However, there are insufficient scientific researches on prognostic immunological SLC3A2 breast cancer (BC) whether everolimus regulates novel related molecular mechanism immuno-oncology context tumor microenvironment (TME), therefore, we see necessity to conduct current silico biological...
Wnt inhibitory factor-1 (WIF-1) acts as a antagonist and tumor suppressor, but hypermethylation of WIF-1 gene promoter low expression activate signaling aberrantly induce the development several human tumors. By using RT-PCR, immunohistochemistry methylation-specific PCR, we analyzed methylation in 4 normal brain tissues, 35 freshly resected astrocytoma tissues glioblastoma-derived cell lines. Significant downregulation mRNA protein levels was observed compared with tissues. association...
Objective. This study aimed to conduct a retrospective observational understand the status of characteristics pain and identify potential variables influencing clinical presentation breakthrough cancer (BTP) in advanced patients. Methods. Advanced patients over 18 years age; diagnosed with any type stage III or IV palliative care ward available data were enrolled between 2018 2020. Demographic pain-related information collected by using structured electronic extraction form from Hospital...
Abstract Background Despite being driven by a strong sense of duty and familial obligation, providing care for patients nearing the end life poses challenges family caregivers. Telemedicine has rapidly gained traction as transformative approach to healthcare delivery, offering an array benefits that could be particularly valuable in end-of-life care. However, research on perspectives telemedicine-based services among caregivers with cancer is limited. Therefore, this study aims explore...
Abstract Background For patients with locally advanced rectal cancer (LARC), total neoadjuvant therapy (TNT), namely, intensifying preoperative treatment through the integration of radiotherapy and systemic chemotherapy before surgery, was commonly recommended as standard treatment. However, risk distant metastasis at 3 years remained higher than 20%, complete response (CR) rate less 30%. Several clinical trials had suggested a when combining single-agent immunotherapy short-course (SCRT)....
Objective: Immune cells play a key role in tumor microenvironment. The purpose of this study was to investigate the infiltration and clinical indication immune including their combined prognostic value microenvironment triple negative breast cancer. Methods: We investigated 100 patients with cancer by Opal/Tyramide Signal Amplification multispectral immunofluorescence between 2003 2017 at Zhejiang Provincial people's Hospital. Intratumoral stromal were classified quantitatively analyzed....
Purpose:We aimed to investigate the association of single-nucleotide polymorphisms (SNPs) in HMGB1, REV3L, and NFE2L2 with prognosis lung cancer patients platinum-based chemotherapy.Methods: We have recruited 348 treated platinum.Log-rank test Cox regression analysis were used assess overall survival (OS) progression-free (PFS) among SNP genotypes. Results:The results revealed that carrying TC or CC genotype REV3L rs462779 (HR=0.67,95% CI=0.51-0.90,P=0.007) AG GG HMGB1 rs1045411 (HR=0.61,95%...
This study aimed to conduct a retrospective cross-sectional investigate the prevalence of symptoms and symptom clusters on sociodemographic disease characteristics, as well factors associated with Do-Not-Resuscitate (DNR) consent. Advanced cancer patients were enrolled between 2018 2020 available data. Demographic clinical data obtained for analysis from Hospital Information System (HIS) in China. Symptom extracted by hierarchical cluster analysis. Chi-square test multiple logistic...
<title>Abstract</title> HKDC1 plays a critical role in tumor progression. However, its functional ovarian cancer (OC) metastasis, lipid metabolism, and immune escape remains incompletely understood. was knocked down overexpressed OC cells to investigate effects underlying mechanisms on evasion. Finally, an mouse model established validate the <italic>in vitro</italic> results. found be highly expressed cell lines. Overexpression of promoted proliferation, migration, invasion cells....
<title>Abstract</title> <bold>Objective: </bold>The aim of the study is to establish a multiparametric MRI (mpMRI)-based peritumoral radiomics nomogram for preoperatively predicting IIA and IIB classification cervical Cancer preoperatively. <bold>Methods: </bold>208 patients with histologically confirmed cancer from three institutions were enrolled in this study. All cases randomly divided into training cohort (n=145) validation (n=63). The performance was assessed respect its calibration,...
This study aimed to investigate the relationship between ZNF582 promoter methylation (ZNF582m) level and radiosensitivity of cervical cancer its biological basis. was a prospective multicenter clinical study, comprising two independent cohorts locally advanced patients. Exfoliated cells were collected at 0, 24, 30, 36, 48, 64 Gy test ZNF582m levels. Radiotherapy response evaluated according RECIST Version. RT-PCR WT used detect mRNA protein expression levels; MTT flow cytometry cell...