A5037313480- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Drug Transport and Resistance Mechanisms
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Head and Neck Cancer Studies
- RNA Research and Splicing
- DNA Repair Mechanisms
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Heat shock proteins research
- Advanced Glycation End Products research
- Cerebrospinal fluid and hydrocephalus
- BRCA gene mutations in cancer
- Genomics and Phylogenetic Studies
- Galectins and Cancer Biology
- Autophagy in Disease and Therapy
- Bacteriophages and microbial interactions
- Muscle Physiology and Disorders
- Lung Cancer Research Studies
- Traditional Chinese Medicine Analysis
- Retinoids in leukemia and cellular processes
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
Second People's Hospital of NanTong
2024
Nantong University
2024
Central South University
2014-2023
Xiangya Hospital Central South University
2014-2023
Hunan Provincial Center for Disease Control and Prevention
2021
PharmacoGenetics (China)
2014
Non-small cell lung cancer (NSCLC) is the most common pathological type of , accounting for approximately 85% cancers. For more than 40 years, platinum (Pt)-based drugs are still one widely used anticancer even in era precision medicine and immunotherapy. However, clinical limitations Pt-based drugs, such as serious side effects drug resistance, have not been well solved. This study constructs a new albumin-encapsulated Pt(IV) nanodrug (HSA@Pt(IV)) based on nanodelivery system. The...
Abstract In this study, we aimed to explore the long noncoding RNA expression pattern in squamous cell lung cancer (SQCC) on a genome-wide scale. Total RNAs were extracted from 16 SQCC patients’ normal and matched tissues by Trizol reagent. The level of scale lncRNA mRNA was determined microarray. qRT-PCR used validate 47 patients. Data analyses performed using R Bioconductor. A total 2,748 up 852 down regulated probes identified be significantly differentially expressed tumor tissues....
Background Over-expressed eukaryotic initiation factor 3a (eIF3a) in non-small cell lung cancer (NSCLC) contributed to cisplatin sensitivity. However, the role of eIF3a oncogenesis was still controversial. This study designed investigate prognostic impact and p27 radically resected NSCLC patients. Methods The expression levels subcellular were evaluated immunohistochemically 537 samples, another cohort 210 stage II Disease specific survival (DSS) disease free (DFS) analyzed by Kaplan-Meier...
As a member of the myotubularin family, related protein 3 (MTMR3) has been demonstrated to participate in tumor development, including oral and colon cancer. However, little is known about its functional roles breast In present study, expression MTMR3 cancer was evaluated by immunohistochemical staining tissues from 172 patients. Online data then used for survival analysis PROGgeneV2 database. vitro, silenced MDA‑MB‑231 cells via lentiviral shRNA transduction. MTT, colony formation flow...
To establish a radiomics nomogram for survival prediction and determine if genomic data were related to signature in advanced nasopharyngeal carcinoma (NPC).Radiomics features extracted from contrast-enhanced T1-weighted images (CE-T1WI) 316 patients. A progression-free (PFS) was developed validated by the combination of clinicopathologic factors. Whole transcriptomics sequencing performed pretreatment tumor samples; correlation gene expression further investigated.A 24-feature-combined...
Cathepsin L (CTSL) is a lysosomal acid cysteine protease that has been implicated in tumorigenesis and malignant progression. In the present study, role of CTSL prognosis breast cancer was evaluated. The prognostic value analyzed using immunohistochemistry patients with cancer, as well online microarray datasets. expression knocked down cell line T‑47D RNA interference. MTT colony formation assays were performed to assess proliferation cells. Cell cycle progression apoptosis measured flow...
Breast cancer (BRCA) is one of the most common malignancies encountered in women worldwide. Lipid metabolism has been found to be involved progression. Steroidogenic acute regulatory protein‑related lipid transfer 4 (STARD4) an important cholesterol transporter mechanism intracellular homeostasis. However, best our knowledge, molecular functions STARD4 BRCA are unclear. Immunohistochemical staining and public dataset analysis were performed investigate expression levels BRCA. In present...
Eukaryotic translation initiation factor 3 subunit A (eIF3a) is the largest of eukaryotic (eIF3). eIF3a plays an integral role in protein biosynthesis, hence impacting onset, development, and treatment tumors. The proteins regulated by are still being explored vivo . In this study, a Cre-loxP system was used to generate conditional knockout mice. Tandem mass tag (TMT) labeling with LC-MS/MS analysis identify differentially expressed (DEPs) fat, lungs, skin, spleen tissue mice controls....
Purpose:We aimed to investigate the association of single-nucleotide polymorphisms (SNPs) in HMGB1, REV3L, and NFE2L2 with prognosis lung cancer patients platinum-based chemotherapy.Methods: We have recruited 348 treated platinum.Log-rank test Cox regression analysis were used assess overall survival (OS) progression-free (PFS) among SNP genotypes. Results:The results revealed that carrying TC or CC genotype REV3L rs462779 (HR=0.67,95% CI=0.51-0.90,P=0.007) AG GG HMGB1 rs1045411 (HR=0.61,95%...
Lung cancer is one of the most prevalent cancers and leading cause cancer-related death in world. Platinum-based chemotherapy plays an important role lung treatment, but therapeutic effect varies from person to person. Heat shock proteins (HSPs) have been reported be associated with survival time patients, which may a potential biomarker treatment. The aim this study was investigate association between genetic polymorphisms prognosis patients treated platinum-based chemotherapy.We performed...
Purpose: Lung cancer is the largest cause of deaths in world. Platinum-based chemotherapy a foundation first-line chemotherapy. However, prognosis lung treated with platinum-based still challenge. Single nucleotide polymorphism non-coding RNA has potential to be biomarker, but its effectiveness yet comprehensively assessed. In this study, we explored association between polymorphisms and patients receiving Materials Methods: For 446 chemotherapy, 22 single microRNA long noncoding were...
Lung adenocarcinoma is the most common subtype of non‑small cell lung carcinoma. Tanshinone I an important fat‑soluble component in extract <em>Salvia miltiorrhiza</em> that has been reported to inhibit proliferation. However, no studies have clearly demonstrated changes gene expression and signaling pathway enrichment following treatment. And it remains unclear whether salvianolate effect on adenocarcinoma. The present study downloaded GSE9315 dataset from Gene Expression Omnibus database...
Lung cancer is still the most lethal malignancy in world, according to report of Cancer Statistics 2021. Platinum-based chemotherapy combined with immunotherapy first-line treatment lung patients. However, 5-year survival rate always affected by adverse reactions and drug resistance caused platinum-based chemotherapy. DNA damage repair system one important mechanisms that can affect response clinical outcomes patients.The objective this study find relationship between polymorphisms genes...
Objective: To investigate the relationships between genetic variants in DNA mismatch repair pathway genes and prognosis of platinum-based chemotherapy lung cancer patients. Methods: 346 patients who received at least two cycles were recruited this study. A total 35 single nucleotide polymorphisms 7 genotyped to their associations with prognosis. Result: The results revealed that carried MSH2 rs4608577 TT genotype had a significantly shorter progression free survival than GG or GT genotypes...
Background. Lung cancer is one of the major causes cancer-related mortality worldwide. DNA repair and damage response contribute to genomic instability that accompanies tumor progression. In this study, we focus on evaluating association between polymorphisms EXO1, RPA1, prognosis in lung patients whom received platinum-based chemotherapy. Methods. 593 were recruited study. We performed genotyping 19 single nucleotide (SNPs) by Sequenom MassARRAY. Cox regression analysis was used assess...
To assesses the impact of integrating hospice care with psychological interventions on patient well-being and to introduce a predictive nomogram model for delirium that incorporates clinical psychosocial variables, thereby improving accuracy in environments.Data from 381 patients treated September 2018 February 2023 were analyzed.The divided into control group (n=177, receiving standard care) an experimental (n=204, combined interventions) according treatment modality.The duration extended...