A5022135589- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Signaling Pathways in Disease
- Circular RNAs in diseases
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- CRISPR and Genetic Engineering
- interferon and immune responses
- Cancer Immunotherapy and Biomarkers
- FOXO transcription factor regulation
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Endoplasmic Reticulum Stress and Disease
- Extracellular vesicles in disease
- Gastrointestinal Tumor Research and Treatment
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Peptidase Inhibition and Analysis
- Pelvic and Acetabular Injuries
- Breast Cancer Treatment Studies
- Epigenetics and DNA Methylation
- Protein Degradation and Inhibitors
- RNA regulation and disease
- PARP inhibition in cancer therapy
Hangzhou Medical College
2020-2025
Zhejiang Provincial People's Hospital
2020-2025
California Northstate University
2025
Zhejiang University
2014-2023
Sir Run Run Shaw Hospital
2016-2021
First Affiliated Hospital Zhejiang University
2021
Second Affiliated Hospital of Zhejiang University
2019-2020
Wenzhou Medical University
2020
Ruian People's Hospital
2020
Nanchang University
2007-2015
Tamoxifen resistance remains a clinical challenge for hormone receptor-positive breast cancer. Recently, dysregulations in autophagy have been suggested as potential mechanism tamoxifen resistance. Although the long noncoding RNA H19 is involved various stages of tumorigenesis, its role unknown. Here, we assessed development tamoxifen-resistant Quantitative real-time PCR analyzed expression cancer tissues. Knockdown was used to assess sensitivity vitro and vivo. Both knockdown overexpression...
Over-accumulation of reactive oxygen species (ROS) causes hepatocyte dysfunction and apoptosis that might lead to the progression liver damage. Sirtuin-3 (SIRT3), main NAD+-dependent deacetylase located in mitochondria, has a critical role regulation mitochondrial function ROS production as well antioxidant mechanism. This study explores roles astragaloside IV (AST-IV) formononetin (FMR) connection with SIRT3 for potential antioxidative effects. It was shown condition combined pre-...
NRF2 is an important regulatory transcription factor involved in tumor immunity and tumorigenesis. In this study, we firstly identified that FKBP4/NR3C1 axis was a novel negative regulator of human breast cancer (BC) cells. The effect FKBP4 appeared to be at protein level since it could not suppress the expression mRNA level. Bioinformatics analysis vitro experiments further demonstrated regulated via regulating nuclear translocation NR3C1. We then reported naringenin, flavonoid, widely...
Long non‑coding RNA (lncRNA) H19 and Lin28 protein have been shown to participate in various pathophysiological processes, including cellular proliferation, autophagy epithelial‑mesenchymal transition (EMT). A number of studies investigated lncRNAs, microRNAs mRNAs, their roles the initiation progression cancer, doing so identifying competitive endogenous (ceRNA) networks, H19/let‑7/Lin28 network. However, whether ceRNA network is involved EMT breast cancer (BC) remains unclear. The present...
Purpose: FKBP4 is a member of the immunophilin protein family, which plays role in immunoregulation and basic cellular processes involving folding trafficking associated with HSP90. However, relationship between abnormal expression clinical outcome luminal A subtype breast cancer (LABC) patients remains to be elucidated. Methods: Oncomine, bc-GenExMiner HPA database were used for data mining analyzing its co-expressed genes. GEPIA was screening genes FKBP4. Results: For first time, we found...
This study was conducted to determine the effects of exogenous zinc-metallothionein (Zn-MT) on anti-oxidative function and pork quality.After feeding a corn-soybean meal-based diet for two weeks, 48 pigs (Duroc × Landrace Chinese Black Pig) were assigned randomly four groups.Pigs in Group 1 maintained under non-stress conditions, whereas Groups 2, 3 4 aggressively handled 25 min produce stress.Pigs 1, 3, received intramuscular administration saline (control group; CON), 0 (negative control...
Abstract White spot disease remains a constant threat to aquaculture worldwide. Hyperthermia has been shown reduce mortality in white syndrome virus ( WSSV )‐infected shrimps, but the mechanism still unclear. In this study, we sought identify host immune factors that contribute inhibition of infection during hyperthermia. ‐infected red swamp crayfish P rocambarus clarkii G irard) cultured at 24 ± 1 °C, transcriptional levels heat shock protein 70 (Hsp70) gene showed modest, 2.2‐fold increase...
// Ji Wang 1, 2, * , Chenyang Ye 3, Demin Lu 4, Yongxia Chen 2 Yunlu Jia Xiaogang Ying Hanchu Xiong Wenhe Zhao Jichun Zhou and Linbo 1 Department of Surgical Oncology, Sir Run Shaw Hospital, College Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, China Biomedical Research Center Key Laboratory Biotherapy Province, 3 Cancer Institute, Prevention Intervention, National Ministry Education, Second Affiliated School 310009, 4 Medical These authors have contributed equally to this work...
Background: Solute Carrier Family 3 Member 2 (SLC3A2) is a member of the solute carrier family that plays pivotal roles in regulation intracellular calcium levels and transports L-type amino acids.However, there are insufficient scientific researches on prognostic immunological SLC3A2 breast cancer (BC) whether everolimus regulates novel related molecular mechanism immuno-oncology context tumor microenvironment (TME), therefore, we see necessity to conduct current silico biological...
Breast cancer (BC) is a disease with morbidity ranking the first of women worldwidely. In current study, 11 DE-miRNAs, consisting four FKBP4 related DE-miRNAs and seven FKBP5 were screened. Four hundred eighty two predicted lncRNAs found for DE-miRNAs. Then, expression prognostic results nine top 20 BC significantly identified. LINC00662 LINC00963 associated patients' overall survival (OS). potential upstream transcription factors identified in motifs Three twenty target genes GO annotation...
Our previous studies revealed the significant roles of FK506-binding protein 4 (FKBP4) in tumorigenesis, however, there has been no pan-cancer analysis FKBP4. Using bioinformatics, current study reported expression and prognostic role FKBP4, correlation between FKBP4 clinicopathological parameters, methylation, molecular network, immunological traits drug sensitivity.
In individuals with stage IB1-IIA2 cervical cancer (CC) who received postoperative radiotherapy ± chemotherapy (PORT/CRT), the interaction between sarcopenia and malnutrition remains elusive, let alone employing a nomogram model based on radiomic features of psoas extracted at level third lumbar vertebra (L3). This study was set to develop radiomics-based predict as per Patient-Generated Subjective Global Assessment (PG-SGA) for CC.In total, 120 CC underwent computed tomography (CT) scans...