A5040843106- Plant Virus Research Studies
- Plant Disease Resistance and Genetics
- Plant and Fungal Interactions Research
- Plant Pathogenic Bacteria Studies
- Gastric Cancer Management and Outcomes
- Plant tissue culture and regeneration
- HER2/EGFR in Cancer Research
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- Diabetes Management and Research
- Breast Cancer Treatment Studies
- Cocoa and Sweet Potato Agronomy
- Transgenic Plants and Applications
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- MicroRNA in disease regulation
- Insect-Plant Interactions and Control
- Estrogen and related hormone effects
- Plant Reproductive Biology
- Diabetes Treatment and Management
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- Helicobacter pylori-related gastroenterology studies
- RNA Research and Splicing
- Retinoids in leukemia and cellular processes
Zhejiang University
2014-2025
Sir Run Run Shaw Hospital
2013-2023
People’s University
2022
Jiangyin People's Hospital
2021
Nantong University
2021
Zhujiang Hospital
2021
Jinan Central Hospital
2020
Fujian Entry - Exit Inspection and Quarantine Bureau
2007-2019
Shanghai Sixth People's Hospital
2013-2015
Chinese Academy of Agricultural Sciences
2015
Abstract Purpose In this study, we aimed to investigate the viability of utilizing CytoSorter ® system detect circulating tumor cells (CTCs) and evaluate diagnostic value CTCs in breast cancer (BC). Methods A total 366 females patients suspected having BC 30 healthy female volunteers were enrolled study. enriched by , a microfluidic‐based capturing platform. CTC detection was performed before operation or biopsy. Based on biopsy results, divided into two groups, namely with benign diseases...
Long non‑coding RNA (lncRNA) H19 and Lin28 protein have been shown to participate in various pathophysiological processes, including cellular proliferation, autophagy epithelial‑mesenchymal transition (EMT). A number of studies investigated lncRNAs, microRNAs mRNAs, their roles the initiation progression cancer, doing so identifying competitive endogenous (ceRNA) networks, H19/let‑7/Lin28 network. However, whether ceRNA network is involved EMT breast cancer (BC) remains unclear. The present...
ABSTRACT Background Evidence suggested that IL‐17A was associated with renal function in type 2 diabetes. We used ultra‐sensitive measurement to detect the concentration of human peripheral blood and explored association diabetic kidney disease (DKD). Methods recruited 138 participants from Shanghai Diabetes Institute Inpatient Database Jiao Tong University Affiliated Sixth People's Hospital. Eighty‐four individuals diagnosed as DKD were cases, 54 diabetes without or retinopathy (DR)...
Maize, a staple food and cash crop worldwide, also serves as critical industrial raw material. However, it is significantly threatened by viral pathogens, particularly maize dwarf mosaic virus (MDMV), the primary cause of disease, debilitating condition affecting cultivation. This study aims to establish multi-gene combined RT-PCR assay for rapid specific, sensitive, reliable detection MDMV without need special expensive equipment. Samples imported maize, sorghum, barley were collected from...
Ten triterpene saponins have been isolated from a MeOH extract of the leaves Ilex oblonga. In their structures, six new triterpenoid were named as oblonganosides H−M (2, 4, 5, and 8−10). All structures elucidated on basis spectroscopic analysis. Among saponins, three compounds (7, 8, 10) showed obvious activities in inhibiting multiplication tobacco mosaic virus (TMV). Keywords: Aquifoliaceae; oblonga; saponin; TMV
Gastric Cancer is one of the most lethal malignancies worldwide. Gamma-glutamyl transpeptidase (GGT) an enzyme mainly involved in cellular glutathione homeostasis. We aim to explore clinical value GGT gastric cancer.Among 322 patients enrolled, 65/82 were determined as positive serum/tumor, respectively. High tumor expression significantly associated with lymph node metastasis, histological subtype, and Her2 expression. Kaplan-Meier curve shows that high have shorter overall survival (P...
Higher Lin28 expression is associated with worse pathologic tumor responses in locally advanced gastric cancer patients undergoing neoadjuvant chemotherapy. However, the characteristics of and its mechanism action chemotherapy resistance still unclear. In this study, we found that transfection into cells (MKN45 MKN28) increased their to chemo-drugs oxaliplatin (OXA), paclitaxel (PTX), doxorubicin (ADM), fluorouracil (5-Fu) compared transfected a control vector. When knockdown by small...
Brucea javanica (L.) Merr. is widely distributed throughout the southern parts of China and has been used in traditional medicine to treat a variety diseases. The objective present study was identify active antiphytoviral compound seeds B. evaluate inhibitory activity against plant virus.Bioassay-guided fractionation most extract from led isolation an which identified as bruceine-D by conventional spectroscopy methods. exhibited significant infection replication tobacco mosaic virus (TMV),...
Previous studies suggested that estrogen receptor alpha (ERα) plays an important role in the chemoresistance of breast cancers. However, large random trials failed to demonstrate any benefit concurrent antagonist tamoxifen on chemotherapy efficacy. Thus, present study, importance ERα cancer cells was investigated.The ERα-transfected Bcap37 and natural ERα-positive T47D were treated using chemotherapeutic agents with or without 17-beta estradiol (E2) pretreatment. Their viabilities assessed...
Malignant granular cell tumors (MGCT) are rare mesenchymal soft tissue neoplasms of Schwann origin without adequate follow-up. This study describes a case MGCT with right breast metastasis following two local recurrences. The patient consented to lumpectomy axillary dissection, abdominal wall and inguinal dissection. Pathological examination revealed that the initial lesions were consistent benign histological performance. later classified as malignant due observation spindling tumor cells,...
Background: Pegylated liposomal doxorubicin (PLD) and epirubicin are both superior variants of commonly applied as basic chemotherapeutics in breast cancer. However, the direct comparison their efficacy side effects has not been adequately reported. This study aimed to compare toxicity PLD neoadjuvant chemotherapy for invasive Patients methods: Women (n = 43) with cancer who received regimens containing (PLD group) were analyzed 1:2 matched those 86) (epirubicin according clinical TNM...
AIM:To investigate the influence of a positive proximal margin in total gastrectomy patients with gastric adenocarcinoma cardia. METHODS:Medical records 191 gastrectomies for cardia between 1995 and 2000 were reviewed.The clinicopathologic features associated determined, predictors survival analyzed. RESULTS:The incidence was 8.4% (16/191).The margins advanced diseases.The tumor size depth invasion independent risk factors margin.The mean group 33.9 mo as compared 62.4 negative (P <...
Preoperative chemotherapy (PCT) has become the standard of care in locally advanced breast cancer. The identification patient-specific tumor characteristics that can improve ability to predict response therapy would help optimize treatment, treatment outcomes, and avoid unnecessary exposure potential toxicities. This study is determine whether selected biomarkers could pathologic (PR) tumors three different PCT regimens, identify a subset patients who benefit from given type treatment. 118...
Prostate cancer presents high occurrence worldwide. Medicinal plants are a major source of novel and potentially therapeutic molecules; therefore, the aim present study was to investigate possible anti-prostate activity afzelin, flavonol glycoside that previously isolated from Nymphaea odorata. The effect afzelin on proliferation androgen-sensitive LNCaP androgen-independent PC-3 cells evaluated by performing water soluble tetrazolium salt-1 assay. In addition, cell cycle prostate lines...
Objectives We aimed to investigate the prognostic value of RRM1 in GC patients. Methods A total assessable 389 patients with clinicopathological and survival information were enrolled from City Hope (COH, n = 67) Zhejiang University (ZJU, 322). protein expression was determined by immunohistochemistry on FFPE tissue samples. Kaplan-Meier Cox analyses used measure survival. Ras/Raf activity invasion assays evaluate role cell lines. Results In vitro experiments demonstrated activated...