A5085635307- Extracellular vesicles in disease
- Sphingolipid Metabolism and Signaling
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Alcohol Consumption and Health Effects
- Biochemical and Molecular Research
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Aldose Reductase and Taurine
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Ubiquitin and proteasome pathways
- Aquaculture disease management and microbiota
- Sulfur Compounds in Biology
- Porphyrin Metabolism and Disorders
- Alkaline Phosphatase Research Studies
- Hedgehog Signaling Pathway Studies
- Ultrasound and Hyperthermia Applications
- interferon and immune responses
- Metabolism, Diabetes, and Cancer
- Inflammatory Bowel Disease
- Wnt/β-catenin signaling in development and cancer
- Ion Channels and Receptors
Ningbo No. 2 Hospital
2015-2024
University of Chinese Academy of Sciences
2019-2024
Ningbo University
2022
Ningbo Medical Center Lihuili Hospital
2022
Sir Run Run Shaw Hospital
2017-2021
Zhejiang University
2017-2021
Guilin Medical University
2018-2020
Blood Center of Zhejiang Province
2020
117th Hospital of People's Liberation Army
2016
Lawrence Berkeley National Laboratory
2007
Colorectal adenocarcinoma (COAD) is a prevalent malignant tumor. Cancer-associated fibroblasts (CAFs)-derived extracellular vesicles (EVs) (CAFs-EVs) are implicated in COAD treatment. This study explored the mechanism of CAFs-EVs COAD. CAFs and normal fibroblast (NFs) were isolated from tissues adjacent tissues. Vimentin, α-SMA, FAP expressions detected. EVs identified. SW480 HCT116 cells co-incubated with EVs. The EV uptake cell behaviors assessed. EV-treated co-cultured human umbilical...
Gastric Cancer is one of the most lethal malignancies worldwide. Gamma-glutamyl transpeptidase (GGT) an enzyme mainly involved in cellular glutathione homeostasis. We aim to explore clinical value GGT gastric cancer.Among 322 patients enrolled, 65/82 were determined as positive serum/tumor, respectively. High tumor expression significantly associated with lymph node metastasis, histological subtype, and Her2 expression. Kaplan-Meier curve shows that high have shorter overall survival (P...
Caulerpin, a secondary metabolite from the marine invasive green algae Caulerpa cylindracea is known to induce mitochondrial dysfunctions. In this study, anticancer property of caulerpin was assessed in panel colorectal cancer cell lines. We demonstrated that inhibited oxidative phosphorylation (OXPHOS) and facilitated an early intervention function, via inhibiting complex I, accompanied by dissipation membrane potential surge reactive oxygen species (ROS) generation. Moreover, response...
Colorectal cancer remains one of the most common cancers in men and women, it accounts for a large proportion cancer-related deaths worldwide. Tripartite motif (TRIM) proteins are novel class single protein RING finger E3 ubiquitin ligases, which have been shown to be involved many cancers. The aim this study was investigate potential role TRIM24 human colorectal cancer. By using lentivirus-mediated RNA interference system, we first explored effect knockdown on HCT116 cell proliferation...
Neutral sphingomyelinase 1 (NSMase1) mediates caspase-3 activation and apoptosis. However, the role of NSMase1, especially exosome-borne NSMase1 in hepatocellular carcinoma (HCC), remains unclear. We report that which converts sphingomyelin (SM) to ceramide, was significantly downregulated HCC tissues. Low expression predicted poor long-term survival patients. downregulation resulted increased SM reduced ceramide (Cer) led an SM/Cer ratio. Interestingly, NSMase activity were also decreased...
Previous studies have demonstrated that microRNA-7-5p (miR-7-5p) functions as a tumor suppressor in certain types of human cancer. However, the role miR-7-5p colorectal cancer (CRC) remains to be investigated. Using reverse transcription-quantitative polymerase chain reaction (RT-qPCR), present study was downregulated CRC tissues and cell lines. In addition, low expression is able predict poor 5-year overall survival rate for patients with CRC. vitro revealed overexpression inhibits...
Hepatocellular carcinoma (HCC) is the most common type of liver cancer. It has a poor prognosis because it often diagnosed at advanced stage when treatments are limited. In addition, HCC pathogenesis not fully understood, and this affected early diagnosis treatment disease. Human alkaline ceramidase 2 (ACER2), key enzyme that regulates hydrolysis cellular ceramides, affects cancer cell survival, however its role in been well characterized. Our results showed ACER2 overexpressed tissues...
Abstract Matrix metalloproteinase 1 (MMP1) encodes endopeptidases associated with degradation of multiple components the extracellular matrix. This function has increasingly been considered to play a major proteolysis role in tumor invasion and metastasis. However, relationship between MMP1 gene expression, tumor-immune microenvironment prognosis hepatocellular carcinoma patients remains mostly unclear. study focused on comprehensive analysis carcinoma, specifically microenvironment....
Colon adenocarcinoma (COAD) is one of the most common types malignancy digestive system, and a better understanding molecular mechanisms will contribute to an improvement in quality life for COAD patients. Cadherin 3 (CDH3), gene encoding P-cadherin, major component adherens junctions closely associated with occurrence development variety tumor types. However, current knowledge regarding role CDH3 limited. The present study aimed identify relative mRNA protein expression levels tissues,...
Randomized trials have shown a survival benefit for fruquintinib over placebo in patients with metastatic colorectal cancer (mCRC) that progressed after standard therapies, but real-world prognostic analyses been seldom reported. We evaluated survival, safety outcomes, and predictive factors treated real-life setting.
Protein phosphatase 5 (PP5) is a unique member of the protein phosphatases family that functions in multiple signaling pathways involved DNA damage, cell cycle control, growth, and apoptosis. Recent evidence indicated PP5 may play role cancer progression. In this study, we aimed to examine biological effect on growth apoptosis human colorectal (CRC). We first knocked down expression RKO cells via short hairpin RNA containing lentivirus system. Then, methylthiazoletetrazolium assay, colony...
Purpose: To design a dual inhibitor of natural origin capable targeting ErbB1 and ErbB2 kinases for the treatment lung cancer.Method: Advanced In silico drug designing techniques were explored in this study. Sequence structure analysis was followed by three dimensional (3D) pharmacophore. The generated model used molecular docking simulation studies predicting best inhibitors, selected inhibitors subjected to absorption, distribution, metabolism, excretion toxicology (ADME/Tox)...
Abstract Long noncoding RNAs (lncRNAs) have important functions in tumor development and progression, including colorectal cancer (CRC), but their roles are not completely understood. In this study, the of lncRNA transmembrane phosphoinositide 3‐phosphatase tensin homolog 2 pseudogene 1 (TPTE2P1), previously implicated gallbladder cell migration invasion, were evaluated CRC. particular, quantitative polymerase chain reaction was used to quantify TPTE2P1 levels tissues lines. The association...
This study aimed to investigate the effect and underlying mechanism of Arginyl-glutamine (AG) dipeptide on dextran sulfate sodium (DSS)-induced colitis by<italic>in vivo</italic>and<italic>in vitro</italic>models.
The National Surgical Adjuvant Breast and Bowel Project (NSABP) B32 trial reported that the detection rate of sentinel lymph nodes by core needle biopsy (CNB) is higher than segmental resection. However, there are few reports regarding vacuum-assisted breast (VABB). Therefore, we analyzed impact preoperative methods on surgical modes 3,966 patients with cancer in our center.In total, female [clinical tumor node metastasis (TNM) stage I-III] were enrolled this study. Preoperative pathological...
Stromal interaction molecule 1 (STIM1) is an endoplasmic reticulum Ca2+ sensor which has been reported to be overexpressed in numerous types of cancer, and involved the cell proliferation, invasion, migration metastasis frequently observed cancer. However, role STIM1 colorectal cancer (CRC) remains unknown. The purpose present study was investigate effect human CRC. expression specifically knocked down using lentivirus‑mediated small hairpin RNA (shRNA) interference techniques CRC lines...
Introduction. Although cetuximab has been widely used in the treatment of colon cancer, a large number patients eventually develop drug resistance. Therefore, it is essential to clarify mechanism Methods. In this study, we combined silico analysis and single guide RNA (sgRNA) library locate cetuximab-sensitive genes. Cell proliferation, apoptosis, cell cycle were assessed validate change sensitivity. Finally, western blotting was performed detect changes epidermal growth factor (EGFR)...