A5101803572- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- Ovarian function and disorders
- Prenatal Screening and Diagnostics
- Tissue Engineering and Regenerative Medicine
- Ovarian cancer diagnosis and treatment
- Trauma and Emergency Care Studies
- Reproductive System and Pregnancy
- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- MicroRNA in disease regulation
- Renal and related cancers
- Bone fractures and treatments
- Hemoglobinopathies and Related Disorders
- Reconstructive Surgery and Microvascular Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Uterine Myomas and Treatments
- Pregnancy and preeclampsia studies
- Infectious Encephalopathies and Encephalitis
- Reproductive Health and Contraception
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Acne and Rosacea Treatments and Effects
- Nuclear Structure and Function
First Affiliated Hospital of Jinan University
2025
Chinese PLA General Hospital
2025
Guangxi Maternal and Child Health Hospital
2011-2024
Shanghai First Maternity and Infant Hospital
2022
Southwest Medical University
2021
Yangtze University
2020
University of Michigan
2015-2019
Xiangya Hospital Central South University
2017-2019
Central South University
2017-2019
PharmacoGenetics (China)
2017-2019
Many prepubertal girls and young women suffer from premature ovarian insufficiency induced by chemotherapy given for treatment of cancer autoimmune diseases. Auto-transplantation cryopreserved tissue could restore the lost endocrine function fertility. Unfortunately, ischemia, inconsistent graft quality risk re-introducing malignant cells may stand in way clinical translation this approach. To address these risks limitations, we engineered an artificial ovary immature follicles using a...
High-grade serous ovarian carcinoma (HGSOC) originates mainly from the fallopian tube (FT) epithelium and always carries early TP53 mutations. We previously reported that tumors initiate in FT fimbria because of apoptotic failure expansion cells with DNA double-strand breaks (DSB) caused by bathing epithelial reactive oxygen species (ROSs) hemoglobin-rich follicular fluid (FF) after ovulation. Because ovulation is frequent HGSOC rare, we hypothesized luteal-phase progesterone (P4) could...
Only recently has attention been focused on the importance of interethnic differences as determinants interindividual variability in drug response. We compared pharmacokinetics and pharmacodynamics morphine eight Chinese white healthy men after 0.15 mg/kg intravenously. The clearance was significantly higher subjects than because an increase partial metabolic by glucuronidation. There no difference metabolism to normorphine. Morphine depressed respiratory response rebreathing carbon dioxide...
Premature ovarian insufficiency is a common complication of anticancer treatments in young women and girls. The ovary complex, highly regulated reproductive organ, whose proper function contingent upon the bidirectional endocrine, paracrine, autocrine signaling. These factors facilitate development follicles, functional units ovary, to progress from gonadotropin-independent, paracrine-controlled early stage gonadotropin-dependent, endocrine-controlled later stage. We hypothesized that low...
Human decidual mesenchymal stem cells (hDMSCs) play crucial roles in pregnancy. The decreased resistance of hDMSCs to oxidative stress is a key factor contributing recurrent spontaneous abortion (RSA). miRNAs have essential functions the proliferation and apoptosis tissues. However, involved regulating remain unclear. Decidual tissues were collected from patients with RSA early pregnancy miscarriages. We assessed antioxidant capacity both groups by detecting relevant indicators. Furthermore,...
Objective: To carry out carrier screening among people of childbearing age, detect the pathogenic genes monogenic genetic diseases and analyze status variants, so as to provide fertility guidance intervention measures for high-risk families. Methods: From August 2022 2023, 1 533 families age who met criteria were recruited in Chinese PLA General Hospital, including a total 3 044 subjects. According standard enrollment procedure, 223 (197 autosomal recessive 26 X-linked genes) subjects...
Various toxicants, drugs and their metabolites carry potential ovarian toxicity. Ovarian follicles, the functional unit of ovary, are susceptible to this type damage at all stages development. However, despite large scale negative impacts, assays that study toxicity limited. Exposure cultured follicles toxicants interest served as an important tool for evaluation toxic effects decades. Mouse on bottom a culture dish continue serve approach mechanistic studies. In paper, we demonstrated...
To determine whether outcomes achieved by new surgeons are attributable to inexperience or differences in the context which care is delivered and patient complexity.Although prior studies suggest that surgeon worse than those of experienced surgeons, factors underlie these phenomena poorly understood.A nationwide observational tapered matching study Medicare patients treated 1221 US hospitals (2009-2013). The primary outcome studied 30-day mortality. Secondary were examined.In total, 694,165...
Objective To improve the accuracy of preimplantation genetic testing (PGT) in deletional α-thalassemia patients. Design Article. Patient(s) fifty-two couples. Intervention(s) Whole genome amplification (WGA), Next-generation sequencing (NGS) and PCR mutation loci detection. Main outcome measures WGA, Single nucleotide polymorphism (SNP) detection results; Analysis embryo chromosome copy number variation (CNV). Results Multiple Displacement Amplification (MDA) Annealing Looping–Based Cycles...
ADSCs encapsulated in biomimetic PEG hydrogels maintain stemness and secrete survival- growth-promoting factors that support <italic>in vitro</italic> folliculogenesis.
Objective: The aim of the study was to address controversy surrounding effects duty hour reform on new surgeon performance, we analyzed patients treated by surgeons following transition independent practice. Summary Background Data: In 2003, affected all US surgical training programs. Its impact performance remains unstudied. Methods: We studied 30-day mortality among 1,483,074 Medicare beneficiaries undergoing general and orthopedic operations between 1999 2003 (“traditional“ era) 2009 2013...
In clinical practice, the success of preimplantation genetic testing for monogenic diseases (PGT-M) thalassemia was hindered by absence probands, incomplete family members, or failure in detecting embryonic gene mutation sites. This study aimed to address these issues.
BACKGROUND:The purpose of triage is to identify patients needing immediate resuscitation, assign a pre-designed patient care area, and initiate diagnostic/therapeutic measures as appropriate.This study aimed use emergency severity index (ESI) in pediatric room. METHODS:From July 2006 August 2010, total 21 904 visited the International Department Beijing Children's Hospital.The ESI was measured by nurses physicians, compared using SPSS.RESULTS: Nurses hospital took approximately 2 minutes for...
Objective To determine if the quantity of skeletal injuries (and timing to fixation) increases mortality or pulmonary morbidity in patients with and without chest injuries. Design Retrospective analysis trauma registry. Statistical multiple logistic regression chi squared analysis. Methods Looking specifically at adult (>16 years), injury was quantified by determining presence absence a fracture specific body regions (humeri, forearm, femur, tibia, spine, pelvis) for maximum 10 The fixation...
Frozen-thawed embryo transfer (FET) is thought to be associated with obstetric and neonatal complications after in vitro fertilization/intracytoplasmic single sperm injection (IVF/ICSI) treatment. The study aimed determine whether the endometrial preparation protocol an influencing factor for these complications.We conducted a retrospective cohort of 3,458 women who had singleton deliveries IVF/ICSI-FET treatment at Centre Reproductive Medicine Shanghai First Maternity Infant Hospital...
Abstract Aim To assess the predictive value of blastocoele re‐expansion time in clinical pregnancy outcome vitrified–warmed cycles. Methods Data on 468 single vitrified–thawed blastocyst transfer cycles (in patients aged <38 years) carried out from January 2012 through December 2012, at Reproductive Medicine Center, Maternal and Child Health Hospital Guangxi Zhuang Autonomous Region, were analyzed. Vitrified–warmed blastocysts divided into three groups according to time: group A, <1 h;...
Objective Febrile seizure (FS) is the most common form of childhood disorders. FS perhaps one frequent causes admittance to pediatric emergency wards worldwide. We aimed identify a new, safe, and effective therapy for preventing recurrence. Methods A total 115 children with history two or more episodes were randomly assigned levetiracetam (LEV) control (LEV/control ratio = 2:1) groups. At onset fever, LEV group was orally administered dose 15–30 mg/kg per day twice daily 1 week. Thereafter,...
Sperm cryopreservation is the most effective method to preserve male fertility but this normally used for motile spermatozoa. Thus, only spermatozoa are in reproductive medicine centers worldwide. The immotile from some problematic patients usually discarded, resulting a missed opportunity of sterility future assisted treatments. Many studies have shown that successful fertilization can be obtained after selection viable sperm completely before ICSI. Whether worth freezing has not been...