A5101951797- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Fungal Biology and Applications
- Cardiac Ischemia and Reperfusion
- Cell death mechanisms and regulation
- Acute Ischemic Stroke Management
- Gut microbiota and health
- Growth Hormone and Insulin-like Growth Factors
- Genomics, phytochemicals, and oxidative stress
- Intracerebral and Subarachnoid Hemorrhage Research
- Clinical Nutrition and Gastroenterology
- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- Lung Cancer Treatments and Mutations
- Global Maternal and Child Health
- Natural Antidiabetic Agents Studies
- Bladder and Urothelial Cancer Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Glycation End Products research
- Polysaccharides and Plant Cell Walls
- Microbial Metabolites in Food Biotechnology
- Mesenchymal stem cell research
- Drug Transport and Resistance Mechanisms
- Maternal and Neonatal Healthcare
Tianjin Medical University Cancer Institute and Hospital
2023-2025
Wuhan Polytechnic University
2024
University of Shanghai for Science and Technology
2022
Academy of State Administration of Grain
2022
Beijing University of Chinese Medicine
2021
Anhui Medical University
2021
Second Affiliated Hospital of Shandong University of TCM
2019
China Jiliang University
2018-2019
Fu Jen Catholic University
1998
Abstract Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) is an immune checkpoint molecule with sequence homology to programmed cell death ligand 1 (PD-L1), which mainly expressed on macrophages and tumor cells. However, whether Siglec-15-induced immunosuppression poor prognosis are independent of PD-L1 remains unclear. In this study, we collected samples 135 non-small lung cancers found that Siglec-15 expression were in cancer by multiple immunofluorescence staining....
<title>Abstract</title> We present 3-year results from the CCICC-002a study (ClinicalTrials.gov number: NCT03987867). Autologous CIK cells immunotherapy plus Sintilimab and chemotherapy demonstrated favorable tolerability encouraging efficacy in previously untreated, advanced NSCLC patients. The enrolled 33 patients (34 were at first analysis, 1 patient was excluded by EGFR mutation secondary biopsy). media follow-up 40.5 months (range, 38.0 to 43.0 months). By cut-off date of October 31,...
Abstract Objective Immunotherapy, specifically immune checkpoint inhibitors (ICIs), has revolutionized cancer treatment. However, it can also cause immune‐related adverse events (irAEs). This study aimed to develop a clinically practical animal model of irAEs using BALB/c mice. Methods Subcutaneous tumors mouse breast 4T1 cells were generated in inbred The mice treated with programmed death‐1 (PD‐1) and cytotoxic t‐lymphocyte antigen 4 (CTLA‐4) once every 3 days for five consecutive...
STUDY OBJECTIVE: The accuracy of the official statistic on infant deaths in Taiwan has been questioned. This study aimed to survey nationwide, measure associated vital statistics, and compare them with statistics assess accuracy. DESIGN AND PARTICIPANTS: A nationwide all gestational outcomes occurring at > or = 20 weeks9 gestation over a three day period (15-17 May 1989) was conducted collect data from 23 counties cities using two stage collection procedure. MAIN RESULTS: derived death...
Auricularia auricula-judae is an important culinary-medicinal mushroom. The A. polysaccharides (AAPs) were prepared from in the early stage through alkali extraction and deproteination with Sevag method, optimal acid hydrolysis conditions established by Box−Behnken to prepare degraded (AAPs-F) AAPs. In this study, a nonenzymatic glycosylation reaction system was used for evaluation of inhibitory effects on formation advanced glycation end products (AGEs). addition, high glucose resistance...
The aim of this study was to investigate the effects dietary l-glutamine (Gln) supplementation on morphology and function intestine growth muscle in piglets. In study, sixteen 21-day-old piglets were randomly divided into two groups: Control group (fed a basal diet) Gln diet supplemented with 0.81% Gln). Blood, gut, samples collected from all Day 20 trial. Compared group, increased (p < 0.05) villus height, width, surface area, height/crypt depth ratio small intestine. Furthermore, total...
The combination of epithelial growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and immune checkpoint (ICIs) leads to an increased incidence severe immune-related adverse events (irAEs). However, the mechanisms underlying macrophages in irAEs have not been elucidated.
Auricularia auricular polysaccharides (AAPs) derived from the dried fruit body of A. are valuable compounds with many bioactivities. This research aimed to investigate antioxidant and anti- diabetic activities these their artificial gastrointestinal fluid hydrolysates (AAPHs).Artificially simulated was used obtain polysaccharide-de- rived fragments, a rat model type 2 diabetes mellitus (T2DM) using high-fat diet low-dose streptozotocin (STZ) established assess anti-diabetic effects.It found...
Thymus quinquecostatus Celak, a kind of food additive and folk medicine, has obvious antioxidative anti-inflammatory effects. However, there have been no reports about the cardioprotective effects polyphenol-rich fraction from Celak (TCPRF). Here, we predicted targets pathways TCPRF related to myocardial ischemia (MI) using network pharmacology, examined as well mechanisms in ISO-induced MI mice. The results verified that could decrease serum CK level, improve ECG pathological alterations...
Spontaneous intracerebral hemorrhage (ICH) is a major cause of death and disability with huge economic burden worldwide. Cerebrolysin (CBL) has been previously used as nootropic drug. Necroptosis programmed cell mechanism that plays vital role in neuronal after ICH. However, the precise necroptosis CBL neuroprotection following ICH not confirmed.In present study, we aimed to investigate neuroprotective effects potential molecular mechanisms ICH-induced early brain injury (EBI) by regulating...
This study aimed to examine the spatial distribution of immune cells by application Gcross function in 170 patients with stage I IIIA lung adenocarcinoma (LUAD) and explore its prognostic value. A total LUAD who underwent radical surgery were enrolled. Paraffinized tumor sections collected for 2 panels multicolor immunofluorescence staining (panel 1: CD4, CD8, FOXP3, CD69, CD39, CD73, DAPI; panel 2: CD68, CD163, CD20, CD11c, PDL1, IDO, DAPI). The categorized as CD8+, CD4+ T helper cell...
Abstract Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) is an immune checkpoint molecule with sequence homology to programmed cell death ligand 1 (PD-L1), which mainly expressed on macrophages and tumor cells. However, whether Siglec-15 induced immunosuppression poor prognosis are independent of PD-L1 remains unclear. In this study, we collected samples 135 non-small lung cancer found that expression were in by multiple immunofluorescence staining. (Mφ-Siglec-15) was...
Background: In recent years, haploid hematopoietic stem cell transplantation has made great progress in the treatment of acquired aplastic anemia, but incidence transplant related complications and mortality are still high, conditioning reginem needs to be further optimized. Aims: To investigate safety efficacy haploidentical with different intensity regimen anemia (AA). Methods: 27 AA patients who underwent Affiliated Hospital Shandong University Traditional Chinese Medicine from July 2017...