A5029031096- Liver Diseases and Immunity
- Liver Disease Diagnosis and Treatment
- Polysaccharides and Plant Cell Walls
- Systemic Lupus Erythematosus Research
- Inflammatory Biomarkers in Disease Prognosis
- MicroRNA in disease regulation
- Hepatitis B Virus Studies
- Liver physiology and pathology
- Biofuel production and bioconversion
- Immune Cell Function and Interaction
- Atherosclerosis and Cardiovascular Diseases
- Plant Gene Expression Analysis
- Plant nutrient uptake and metabolism
- Immune Response and Inflammation
- Liver Disease and Transplantation
- Plant Molecular Biology Research
- Diabetes and associated disorders
- Monoclonal and Polyclonal Antibodies Research
- Circular RNAs in diseases
- Pediatric Hepatobiliary Diseases and Treatments
- Glycosylation and Glycoproteins Research
- T-cell and B-cell Immunology
- Antifungal resistance and susceptibility
- Pancreatitis Pathology and Treatment
- Advanced Biosensing Techniques and Applications
Second Military Medical University
2010-2019
DHL (United States)
2016
Changhai Hospital
2014
Shanghai Changzheng Hospital
2009-2013
University of Georgia
1997-2012
Shanghai Clinical Research Center
2012
University of California, Davis
2011
Suzhou Institute of Nano-tech and Nano-bionics
2010
Peking University
2010
Chinese Academy of Sciences
2010
It has been proposed that the transcriptional regulation of secondary wall biosynthesis in Arabidopsis is controlled by a network mediated SND1 and its close homologs. Uncovering all transcription factors deciphering their interrelationships are essential for our understanding molecular mechanisms underlying walls, major constituent wood fibers. Here, we present functional evidence MYB83 factor another switch SND1-mediated regulating biosynthesis. specifically expressed fibers vessels where...
Although there have been extensive investigations on neutrophil to lymphocyte ratio (NLR), platelet (PLR) and mean volume (MPV) in many diseases, their roles systemic lupus erythematosus (SLE) remain unclear. The purpose of the present study was evaluate NLR, PLR, MPV levels adult SLE patients explore clinical significance.A retrospective involving 154 151 healthy controls performed. All characteristics were extracted from medical records. between compared, correlations these indexes...
The bulk of grass biomass potentially useful for cellulose-based biofuel production is the remains secondary wall-containing sclerenchymatous fibers. Hence, it important to uncover molecular mechanisms underlying regulation wall thickening in species. So far, little known about transcriptional regulatory switches responsible activation biosynthetic program Here, we report roles a group rice and maize NAC MYB transcription factors biosynthesis. wall-associated NACs (namely OsSWNs ZmSWNs) were...
Arabidopsis develops interfascicular fibers in stems for needed support of shoots. To study the molecular mechanisms controlling fiber differentiation, we isolated an mutant (ifl1) by screening ethyl methanesulfonate-mutagenized populations. This lacks normal stems. Interestingly, some cells were sclerified upper parts but not basal ifl1 These differentiated at a position different from that wild type. Lack correlated with dramatic change stem strength. Stems could stand erect and easily...
Summary Primary biliary cirrhosis (PBC) is an organ-specific autoimmune liver disease characterized by progressive loss of intrahepatic small bile ducts. Cellular immune mechanisms involving T cell reaction are thought to be involved significantly in the pathogenesis PBC. Recent studies have independently revealed enhanced helper type 17 (Th17) response and weakened regulatory (Treg) some diseases, indicating a role Th17/Treg imbalance autoimmunity. This prompted us investigate whether...
Xylan is one of the major polysaccharides in cellulosic biomass, and understanding mechanisms underlying xylan biosynthesis will potentially help us design strategies to produce biomass better suited for biofuel production. Although a number genes have been shown be essential biosynthesis, involved acetylation not yet identified. Here, we report comprehensive genetic functional studies four Arabidopsis REDUCED WALL ACETYLATION (RWA) demonstrate their involvement during secondary wall...
This study was aimed to evaluate levels of neutrophil- (NLR), monocyte- (MLR), eosinophil- (ELR), and basophil-lymphocyte ratio (BLR) their association with inflammatory markers in systemic autoimmune rheumatic diseases (SARDs). A total 1139 SARD patients 170 healthy individuals were enrolled. Clinical laboratory data extracted. NLR MLR significantly increased, but BLR decreased most (p < 0.05). ELR lupus erythematosus (SLE) patients, increased those other SARDs 0.001). In SLE C-reactive...
Xylan, the second most abundant cell wall polysaccharide, is composed of a linear backbone β-(1,4)-linked xylosyl residues that are often substituted with sugar side chains, such as glucuronic acid (GlcA) and methylglucuronic (MeGlcA). It has recently been shown mutations two Arabidopsis family GT8 genes, GUX1 GUX2, affect addition GlcA MeGlcA to xylan, but it not known whether they encode glucuronyltransferases (GlcATs) or indirectly regulate GlcAT activity. In this study, we performed...
Abstract Background: Autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) are two autoimmune diseases of unknown etiology. Genetic factors appear to be involved in the pathogenesis both diseases. Vitamin D has been shown exert multiple immunomodulatory effects, which acts through its own receptor (VDR). Polymorphisms VDR had implicated several In present study, association between Chinese patients with AIH, PBC polymorphisms exon 2, intron 8 9 vitamin genes was studied. Methods:...
Xylan is the second most abundant polysaccharide in dicot wood. Unraveling biosynthetic pathway of xylan important not only for our understanding process wood formation but also rational engineering biofuel production. Although several glycosyltransferases are implicated glucuronoxylan (GX) biosynthesis Arabidopsis, whether their close orthologs woody tree species essential GX during has been investigated. In fact, no studies have reported to evaluate effects alterations secondary...
The FRAGILE FIBER8 (FRA8) gene was previously shown to be required for the biosynthesis of reducing end tetrasaccharide sequence glucuronoxylan (GX) in Arabidopsis thaliana. Here, we demonstrate that F8H, a close homolog FRA8, is functional paralog FRA8 involved GX biosynthesis. F8H preferentially expressed xylem cells, which secondary walls contain an abundant amount GX, and protein targeted Golgi where synthesized. Overexpression fra8 mutant completely complemented phenotypes including...
The bone marrow microenvironment plays a role in myeloma cell proliferation and adhesion-mediated drug resistance. In this study, we investigated microRNA-21 (miR-21) expression changes cells that adhered to stromal (BMSCs). addition, studied the synergistic effect of miR-21 inhibition with dexamethasone (Dex), doxorubicin (Dox), or bortezomib (Bort) on survival. We found up-regulation was partially driven by nuclear factor-κB (NF-κB) signaling via adhesion BMSCs. also confirmed RhoB is...
Xylan is made of a linear chain β-1,4-linked xylosyl residues, some which are substituted with side chains, such as glucuronic acid (GlcA), methylglucuronic (MeGlcA) and arabinose, depending on the source xylan. Although past studies have revealed number genes involved in elongation xylan backbone addition GlcA arabinosyl no been shown to be implicated glucuronoxylan methylation. In this report, we investigated roles three Arabidopsis genes, namely GLUCURONOXYLAN METHYLTRANSFERASE1 (GXM1),...
Xylan is the second most abundant polysaccharide in plant biomass targeted for biofuel production. Therefore, it imperative to understand biochemical mechanism underlying xylan biosynthesis. Although previous genetic studies have identified several genes implicated biosynthesis, proof of any their encoded proteins as a xylosyltransferase (XylT) responsible backbone biosynthesis still lacking. In this study, we investigated enzymatic activities two Arabidopsis thaliana GT43 members, IRX9...
Dicot wood is mainly composed of cellulose, lignin and glucuronoxylan (GX). Although the biosynthetic genes for cellulose have been studied intensively, little known about involved in biosynthesis GX during formation. Here, we report molecular characterization two genes, PoGT8D PoGT43B, which encode putative glycosyltransferases, hybrid poplar Populus alba x tremula. The predicted amino acid sequences PoGT43B exhibit 89 75% similarity to Arabidopsis thaliana IRREGULAR XYLEM8 (IRX8) IRX9,...
Abstract: A major enigma of primary biliary cirrhosis (PBC) is the selective targeting cells. Our laboratory has reported that after apoptosis, human intrahepatic epithelial cells (HiBECs) translocate E2 subunit pyruvate dehydrogenase complex immunologically intact into apoptotic bodies, forming an apotope. However, cell type and specificity this reaction not been fully defined. To address issue, we investigated whether complex, branched chain 2-oxo acid oxo-glutarate four additional inner...
MicroRNA, as an important regulator of gene expression, has been found to be associated with several diseases. MicroRNA expression profiles have identified in autoimmune diseases, such rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis. However, the profile peripheral blood mononuclear cells (PBMCs) from primary biliary cirrhosis (PBC) patients role microRNA PBC remained unclear. The present study aimed explore abnormal regulation PBC.MicroRNA array was performed...