Introduction: Linezolid is an oxazolidinone antibiotic that active against drug-resistant Gram-positive bacteria and multidrug-resistant Mycobacterium tuberculosis . Real-world studies on the safety of linezolid in large populations are lacking. This study aimed to determine adverse events associated with real-world settings by analyzing data from US Food Drug Administration (FDA) Adverse Event Reporting System (FAERS). Methods: We retrospectively extracted reports drug (ADEs) FAERS database...

This study aimed to evaluate the performance of cuffless blood pressure (BP) measurement techniques in a large and diverse cohort participants. We enrolled 3077 participants (aged 18-75, 65.16% women, 35.91% hypertensive participants) conducted followed-up for approximately 1 month. Electrocardiogram, pulse wave, multiwavelength photoplethysmogram signals were simultaneously recorded using smartwatches; dual-observer auscultation systolic BP (SBP) diastolic (DBP) reference measurements also...

Mepolizumab is primarily used in the treatment of asthma, eosinophilic granulomatosis with polyangiitis, eosinophilia syndrome, and chronic rhinitis nasal polyps. The information about its adverse drug reactions mainly derived from clinical trials, there a shortage real-world studies extensive sample sizes. In this study, U.S. FDA’s Adverse Event Reporting System (FAERS) database was analyzed to evaluate side effects mepolizumab. A total 18,040 reports mepolizumab-associated events were...

Introduction: Etoposide is a broad-spectrum antitumor drug that has been extensively studied in clinical trials. However, limited information available regarding its real-world adverse reactions. Therefore, this study aimed to assess and evaluate etoposide-related events setting by using data mining method on the U.S. Food Drug Administration Adverse Event Reporting System (FAERS) database. Methods: Through analysis of 16,134,686 reports FAERS database, total 9,892 (ADEs) were identified. To...

Tunable chirality of optical vortices is a research hotspot in recent years due to its important role light-matter interaction. As dynamical quantity related the electric and magnetic fields, distribution an vortex generally straight along beam propagation axis homogeneous medium. In this Letter, we present curved distributions generated by Janus spheres that consist two halves with different refractive indices under illumination vortices. The underlying physical mechanism interference...

Ferroelectric materials have emerged as significant research hotspots within the field of science and engineering, primarily due to their unique electrical properties. However, characteristics these are influenced by various factors, including material composition, microstructure, preparation processes, which introduce considerable randomness uncertainty. Traditional experimental simulation methods often insufficient for capturing complex interactions, thereby hindering prediction...

The Hermite-Gauss mode (HGM) has received great attention due to its interesting properties and extensive applications. In this Letter, we propose a comprehensive theory of the enhanced photonic spin Hall effect (PSHE) for high order HGM under p- or s-polarization near Brewster's angle (BA) on generic conducting sheet. This BA rises from destructive interference induced by surface current such transverse PSHE shift can be tailored altering sheet conductivity. Besides, design enabled flexible...

Background Elexacaftor/Tezacaftor/Ivacaftor (ETI) has demonstrated significant efficacy in enhancing clinical outcomes for patients with cystic fibrosis (CF). Despite this, comprehensive post-marketing assessments of its adverse drug events (ADEs) remain insufficient. This study aims to analyze the ADEs associated ETI using U.S. FDA Adverse Event Reporting System (FAERS). Methods We conducted a pharmacovigilance analysis utilizing FAERS data from Q4 2019 Q3 2024. Reports related were...

This study proposes a novel approach utilizing Conditional Generative Adversarial Networks (CGANs) to accelerate wideband acoustic state analysis, addressing the computational challenges in traditional Boundary Element Method (BEM) approaches. Traditional BEM-based analysis requires repeated computation of frequency-dependent system matrices across multiple frequencies, leading significant costs. The asymmetry and full-rank nature BEM coefficient further increase demands, particularly...

For practical wireless communication links, one of the critical challenges is random fluctuation turbulence that will impair link performance. Here a transmission model partially coherent elegant Laguerre-Gaussian (ELG) beams in oceanic established. An analytical formula for channel capacity ELG beam propagating through turbulent ocean derived. The effects on evolution performance are studied quantitatively series numerical simulations. Research results show decreasing rate dissipation...

It is widely known that chemotherapy-induced apoptosis of granulosa was the main reason for premature ovarian failure (POF). In addition, accumulating evidence has demonstrated autophagy involved in it. Studies before have reported fibroblast growth factor-2 (FGF2) could attenuate cell death via regulating autophagy. our previous study, FGF2 decrease cisplatin-induced POF mice. Furthermore, obesity-associated protein [fat mass and (FTO)], which decreased significantly mice, inhibit...

In this paper, we introduce an efficient numerical method based on surface integral equations to characterize the scattering of a zero-order Bessel beam by arbitrarily shaped homogeneous dielectric particles. The incident is described vector expressions in terms electric and magnetic fields that perfectly satisfy Maxwell's equations. problems involving particles with arbitrary shapes are formulated current combined-field equation modeled using triangular patches. Solutions performed...

The scattering of an on-axis incident zero-order Bessel beam by a concentric sphere is firstly investigated using analytical method. Based on the spherical vector wave functions, expansion expressions are derived in terms electric and magnetic fields that satisfy Maxwell's equations. According to integral localized approximation, formula for calculation shape coefficients given. present method validated comparison result numerical obtained from surface equation effects half-angle, refractive...

Diabase dikes are extensively distributed in the Xiongcun porphyry copper–gold district southern margin of Lhasa terrane. Here, we report zircon U–Pb ages determined by laser ablation inductively coupled plasma mass spectrometry (LA‐ICP‐MS) along with Hf isotopic, whole‐rock elemental, and Sr–Nd–Pb isotopic data for these diabase dikes. Zircons from one yielded an emplacement age 165.3 ± 1.0 Ma. The display subalkaline features tholeiite compositions. They enriched large‐ion lithophile...

With the help of generalized Huygens-Fresnel integral, an analytical expression for self-healing a partially coherent radially polarized twisted (PCRPT) beam is derived. The coherence and polarization properties PCRPT in propagation are studied detail. It shows that existence twist phase double-edged sword beam. increase factor, ability intensity distribution decreases. However, anti-disturbance performance improves at same time. Besides, proved own slight when obstacle small. Our results...