A5108058487- MicroRNA in disease regulation
- Hippo pathway signaling and YAP/TAZ
- Reproductive System and Pregnancy
- Circular RNAs in diseases
- Reproductive Biology and Fertility
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- Kruppel-like factors research
- RNA modifications and cancer
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Pluripotent Stem Cells Research
- Advanced Neuroimaging Techniques and Applications
- Ferroptosis and cancer prognosis
- Cerebrospinal fluid and hydrocephalus
- Cancer, Hypoxia, and Metabolism
- Fibroblast Growth Factor Research
- Lung Cancer Treatments and Mutations
- Advanced Breast Cancer Therapies
- Anesthesia and Neurotoxicity Research
- Metal complexes synthesis and properties
- Forensic and Genetic Research
- Neurological and metabolic disorders
- Cancer Cells and Metastasis
- Endometrial and Cervical Cancer Treatments
Shihezi University
2025
First Affiliated Hospital of Xi'an Jiaotong University
2011-2024
Ruijin Hospital
2024
Shanghai Jiao Tong University
2024
Xi'an Jiaotong University
2011-2022
Young female patients who receive chemotherapy frequently face premature ovarian failure (POF). The therapeutic potential of stem cells in these has been explored derived from different sources. However, many types are either difficult to obtain or obtaining them involves invasive procedures. Here, we show that menstrual-derived (MenSCs) easy access and exhibit mesenchymal cell-like properties. MenSCs therefore a novel source can be used for tissue repair. aim this study was explore the...
// Yue Teng 1, * , Yan Zhang 2, Kai Qu 3, Xinyuan Yang 1 Jing Fu Wei Chen 3 Xu Li 2 Department of Obstetrics and Gynecology, The First Affiliated Hospital Xi'an Jiaotong University, 710061, China Center for Translational Medicine, Hepatobiliary Surgery, These authors have contributed equally to this work Correspondence to: Li, e-mail: lixuxjtu@126.com Keywords: epithelial ovarian cancer, Warburg effect, microRNA, miR-29b, AKT Received: April 11, 2015 Accepted: September 14, Published:...
Introduction: Etoposide is a broad-spectrum antitumor drug that has been extensively studied in clinical trials. However, limited information available regarding its real-world adverse reactions. Therefore, this study aimed to assess and evaluate etoposide-related events setting by using data mining method on the U.S. Food Drug Administration Adverse Event Reporting System (FAERS) database. Methods: Through analysis of 16,134,686 reports FAERS database, total 9,892 (ADEs) were identified. To...
Premature ovarian failure (POF) is a serious problem for young women who receive chemotherapy, and its pathophysiological basis the dysfunction of granulosa cells. According to previous reports, menstrual-derived stem cells (MenSCs) can restore function folliculogenesis in mice with chemotherapy-induced POF. Fat mass- obesity-associated (FTO) was reported be associated oocyte development maturation. FTO decreased POF may biomarker occurrence Knockdown promoted cell apoptosis inhibited...
Introduction: The discovery of neurotrophic tyrosine receptor kinase ( NTRK ) gene fusions has facilitated the development precision oncology. Two first-generation inhibitors (larotrectinib and entrectinib) are currently approved for treatment patients with solid tumors harboring fusions. Nevertheless, comprehensive profiling at pan-cancer genomic level real-world studies pertaining to adverse events lacking. Methods: We characterize genome through multi-omics databases such as Cancer Genome...
Long non-coding RNAs (lncRNAs) are among the most abundant types of in genome and exhibit particularly high expression levels brain, where they play crucial roles various neurophysiological neuropathological processes. Although ischemic stroke is a complex multifactorial disease, involvement brain-derived lncRNAs its intricate regulatory networks remains inadequately understood. In this study, we established cerebral ischemia-reperfusion injury model using middle artery occlusion (MCAO) male...
Mesenchymal stem cells (MSCs) can exhibit either prooncogenic or antitumor properties depending on the context. Based our previous study, we hypothesized that MSCs engineered to deliver IFN-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>γ</mml:mi></mml:mrow></mml:math>would kill cancer through persistent activation of TRAIL pathway. Human bone-marrow (BM-) derived were isolated, amplified, and transduced with a lentiviral vector encoding...
MicroRNAs (miRNAs) are small non-coding RNAs composed of 18-25 nucleotides that regulate the expression approximately 30% human protein coding genes. Dysregulation miRNAs plays a pivotal role in initiation and progression malignancies. Our study has shown microRNA-34a (miR-34a) was upregulated endometrial cancer stem cells (ECSCs). However, it is unknown how miR-34a regulates itself. Here, we report directly functionally targeted Notch1. MiR-34a inhibited proliferation, migration, invasion,...
It is widely known that chemotherapy-induced apoptosis of granulosa was the main reason for premature ovarian failure (POF). In addition, accumulating evidence has demonstrated autophagy involved in it. Studies before have reported fibroblast growth factor-2 (FGF2) could attenuate cell death via regulating autophagy. our previous study, FGF2 decrease cisplatin-induced POF mice. Furthermore, obesity-associated protein [fat mass and (FTO)], which decreased significantly mice, inhibit...
Nerve growth factor (NGF) is increasingly implicated in cervical cancer progression, but its mechanism unclear. Here, studies demonstrate that NGF inhibits the Hippo signaling pathway and activates Yes-associated protein (YAP) to induce cell proliferation migration. Our results suggested stimulation of promoted migration activated YAP HeLa C-33A lines. The expression target genes (CTGF ANKRD1) was upregulated after treatment. inhibitor Ro 08-2750 siRNA-mediated receptor gene silencing...
Premature ovarian failure (POF) is a complicated disorder related to the apoptosis of granulosa cells. The incidence chemotherapy-associated POF rising dramatically owing increasing proportion cancer in adolescents. According previous studies, oxidative stress caused by chemotherapeutic agents plays an important role development POF. However, exact effects nuclear factor-erythroid 2-related factor2 (NRF2), pivotal anti-oxidative factor, are still unknown Firstly, we manipulated NRF2...
Cervical, ovarian, and endometrial cancers are common in the female reproductive system. Cervical cancer starts from cervix, while ovarian develops when abnormal cells grow ovary. Endometrial or uterine lining of womb endometrium. Approximately 12,000 women affected every year by cervical United States. Squamous cell carcinoma antigen (SCC-Ag) is a well-established biomarker serum for diagnosing gynecological cancers, its levels were observed to be elevated cervical, patients. Moreover,...
Anillin (ANLN) is a unique scaffolding, actin-binding protein, which essential for the integrity and ingression of cleavage furrow. It mainly involved in cytokinesis process, while its role various tumors has not been fully addressed remains largely elusive. To provide thorough perspective ANLN's roles among diverse malignancies, we conducted comprehensive, pan-cancer analysis about ANLN, including but limited to gene expression levels, prognostic value, biological functions, interacting...
Endometrial cancer (EC) kills about 76,000 women worldwide, with the highest incidence in industrialized countries. Because of rise disease mortality and new diagnoses, EC is now a top priority for women’s health. Serine racemase (SRR) thought to play role central nervous system, but its cancers, particularly EC, largely unknown. The current study starts pan-cancer examination SRR’s expression prognostic value before delving into potential cancer-suppressing effect patients EC. SRR may...
Premature ovarian failure (POF) is a devastating condition for women under 40 years old. Chemotherapy, especially the use of cisplatin, has been demonstrated to promote apoptosis granulosa cells in primary and secondary follicles, leading POF. Our previous studies that fat mass- obesity-associated (FTO) plays an essential role protecting from cisplatin-induced cytotoxicity. Various have suggested Hippo/YAP signalling pathway significant regulating cell proliferation. Additionally, YAP1 main...
<title>Abstract</title> The free water imaging of choroid plexus (CP) may improve the evaluation Alzheimer's disease (AD). Our study investigated role fraction (FWf) CP in AD by including 216 participants (133 Aβ + and 83 Aβ- controls) continuously enrolled NeuroBank-Dementia cohort at Ruijin Hospital (RJNB-D). At baseline, showed higher (FWf), increased white matter hyperintensity (WMH) volume, decreased diffusion tensor image analysis perivascular space (DTI-ALPS). In participants,...
<title>Abstract</title> Free-water imaging of the choroid plexus (CP) is an index revealing components CP, which may improve evaluation Alzheimer's disease (AD).<bold> </bold>Our study evaluated free water fraction (FWf) CP in 216 participants (133 Aβ+ and 83 Aβ- controls) continuously enrolled Ruijin NeuroBank Disease Dementia (RJNB-D) cohort. The ADNI dataset was used for external validation. Assessments AD neurodegeneration included Aβ-PET, Tau-PET, synaptic vesicle glycoprotein 2A-PET...
The purpose of this study was to explore the change telomerase in passage from human endometrial stromal stem cells isolated endometrium. Telomerase activity cultured assessed at mRNA and protein levels using RT-PCR immunohistochemistry technique. were higher early passages, then had a gradually decreased trend immunoreactive intensity weakened positive with progressive cells. These results suggest that is contributed insenecence cell.