A5027500343- Global Education and Multiculturalism
- Robot Manipulation and Learning
- Hepatocellular Carcinoma Treatment and Prognosis
- International Student and Expatriate Challenges
- Renal cell carcinoma treatment
- Pharmacogenetics and Drug Metabolism
- Higher Education Governance and Development
- PI3K/AKT/mTOR signaling in cancer
- Migration, Ethnicity, and Economy
- Analytical Chemistry and Chromatography
- Labor Movements and Unions
- Human Pose and Action Recognition
- Adhesion, Friction, and Surface Interactions
- Drug Transport and Resistance Mechanisms
- Nonlinear Differential Equations Analysis
- Reflective Practices in Education
- Wnt/β-catenin signaling in development and cancer
- Robotic Path Planning Algorithms
- Higher Education Practises and Engagement
- Force Microscopy Techniques and Applications
- Pancreatic and Hepatic Oncology Research
- Metabolomics and Mass Spectrometry Studies
- Liver physiology and pathology
- Cancer Mechanisms and Therapy
- Evaluation of Teaching Practices
Shanghai Aerospace Automobile Electromechanical (China)
2022-2024
North China Electric Power University
2024
University of Toronto
2023-2024
University of Calgary
2016-2024
Shanghai Ocean University
2022-2023
The University of Texas at Dallas
2023
Vector Institute
2023
College of Marin
2022
Shandong First Medical University
2019-2021
Shandong University
2019-2021
Recent work has demonstrated the ability of deep reinforcement learning (RL) algorithms to learn complex robotic behaviours in simulation, including domain multi-fingered manipulation. However, such models can be challenging transfer real world due gap between simulation and reality. In this paper, we present our techniques train a) a policy that perform robust dexterous manipulation on an anthropomorphic robot hand b) pose estimator suitable for providing reliable real-time information...
We present <sc xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Orbit</small> , a unified and modular framework for robot learning powered by xmlns:xlink="http://www.w3.org/1999/xlink">Nvidia</small> Isaac Sim. It offers design to easily efficiently create robotic environments with photo-realistic scenes high-fidelity rigid deformable body simulation. With we provide suite of benchmark tasks varying difficulty– from single-stage cabinet opening cloth...
Previous game-theoretic studies of vaccination behavior typically have often assumed that populations are homogeneously mixed and individuals fully rational. In reality, there is heterogeneity in the number contacts per individual, tend to imitate others who appear adopted successful strategies. Here, we use network-based mathematical models study effects both imitation contact on coverage disease dynamics. We integrate network epidemiological with a framework for decision-making, within...
Abstract Friction as a fundamental physical phenomenon dominates nature and human civilization, among which the achievement of molecular rolling lubrication is desired to bring another breakthrough, like macroscale design wheel. Herein, an edge self-curling nanodeformation graphite nanosheets (GNSs) at cryogenic temperature found, then used promote formation nanorollers in friction process towards lubrication. The observation parallel interface give experimental evidence for occurrence...
Tankyrase (TNKS) is a poly-ADP-ribosylating protein (PARP) whose activity suppresses cellular axin levels and elevates β-catenin concentrations, resulting in increased oncogene expression. The inhibition of tankyrase (TNKS1 2) may reduce the β-catenin-mediated transcription inhibit tumorigenesis. Compound 1 previously described moderately potent inhibitor that suffers from poor pharmacokinetic properties. Herein, we describe utilization structure-based design molecular modeling toward novel,...
Canada selects immigrants based on their potential contribution to the country's knowledge-based economy. This selection process commodifies through neoliberal dominance demonstrating reciprocal relationship between and work. literature review draws intersectionality examine precarious nature of work in context Canadian immigration. The contributions this take three forms. First, racialization remains central operation a hierarchical skill regime skin colour rather than qualifications....
The general consensus from epidemiological game-theory studies is that vaccination coverage driven by self-interest (Nash vaccination) generally lower than group-optimal (utilitarian vaccination). However, diseases become more severe with age, such as chickenpox, pose an exception to this consensus. An individual choice be vaccinated against chickenpox has the potential harm those not increasing average age at infection and thus severity of well already probability breakthrough infection. To...
Tankyrases (TNKS1 and TNKS2) are proteins in the poly ADP-ribose polymerase (PARP) family. They have been shown to directly bind axin proteins, which negatively regulate Wnt pathway by promoting β-catenin degradation. Inhibition of tankyrases may offer a novel approach treatment APC-mutant colorectal cancer. Hit compound 8 was identified as an inhibitor through combination substructure searching Amgen collection based on minimal binding pharmacophore hypothesis high-throughput screening....
Deregulation of the receptor tyrosine kinase mesenchymal epithelial transition factor (MET) has been implicated in several human cancers and is an attractive target for small molecule drug discovery. Herein, we report discovery compound 23 (AMG 337), which demonstrates nanomolar inhibition MET activity, desirable preclinical pharmacokinetics, significant phosphorylation mice, robust tumor growth a MET-dependent mouse efficacy model.
The overexpression of c-Met and/or hepatocyte growth factor (HGF), the amplification MET gene, and mutations in kinase domain can activate signaling pathways that contribute to cancer progression by enabling tumor cell proliferation, survival, invasion, metastasis. Herein, we report discovery 8-fluorotriazolopyridines as inhibitors activity. Optimization 8-fluorotriazolopyridine scaffold through combination structure-based drug design, SAR studies, metabolite identification provided potent...
RATIONALE Although Desorption Electrospray Ionization (DESI) Mass Spectrometry Imaging (MSI) is uniquely suited for whole-body (WB) tissue distribution study of drugs, success in this area has been difficult. Here, we present WB studies using DESI-MSI and a new histological tissue-friendly solvent system. METHODS Neonate pups were dosed subcutaneously (SC) with clozapine, compound 1, 2, or 3. Following euthanization by hypothermia, neonates underwent transcardiac perfusion (saline) to remove...
Vaccination has proven effective in controlling many infectious diseases. However, differential effectiveness with regard to pathogen genotype is a frequent reason for failures vaccine development. Often, insufficient immune response induced prevent infection by the diversity of existing serotypes present pathogenic populations bacteria. These vaccines that target too narrow spectrum do not offer sufficient prevention infections, and can also lead undesirable strain replacements. Here, we...
Chromium poisoning has become one of the most common heavy metal occupational diseases with high morbidity and mortality. However, antidotes detoxify whole body are highly toxic. To achieve hepato-targeted chromium detoxification, a novel strategy was developed using aging erythrocyte membranes (AEMs) as biomimetic material coated dimercaptosuccinic acid (DMSA) nanostructured lipid carrier to construct nano-drug delivery system. The particle size, potential, drug loading, encapsulation rate,...
High-resolution accurate MS with an LTQ-Orbitrap was used to identify quinone imine metabolites derived from the 5-hydroxy (5-OH) and 4 prime-hydroxy (4'-OH) glutathione conjugates of diclofenac in rat bile. The initial formed by oxidation have been postulated be reactive intermediates potentially involved diclofenac-mediated hepatotoxicity; while these could using vitro systems, they never detected vivo. This report describes identification secondary 5-OH 4'-OH To verify proposed...
For transient mixed Elastohydrodynamic lubrication (EHL) problems, a novel solution is required to predict friction loss and wear in sliding or rolling parts. However, existing solutions have numerous limitations. In general, the lower oil film thickness is, more serious non-linear problem is. This paper presents an efficient tackle non-linearity of EHL problem. The elastic deformation fluid–solid iteration coupling divided into two parts: One induced by hydrodynamic pressure. part obtained...
AMG 458 {1-(2-hydroxy-2-methylpropyl)-N-[5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl]-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide} is a potent, selective inhibitor of c-Met, receptor tyrosine kinase that often deregulated in cancer. was observed to bind covalently liver microsomal proteins from rats and humans the absence NADPH. When [(14)C]AMG incubated with microsomes presence glutathione N-acetyl cysteine, thioether adducts were detected by radiochromatography LC/MS/MS...
Many synthetic bio-inspired adhesives consist of an array microfibrils attached to elastic backing layer, resulting in a tough and compliant structure. The surface region is usually subjected large nonlinear deformations during contact with indenter, leading strongly response. In order understand the compliance fibrillar regions, we examine deformation single fibril combination shear normal loads. An exact closed-form solution obtained using elliptic functions. prediction our model compares...