A5102001749- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Tribology and Wear Analysis
- Coenzyme Q10 studies and effects
- Polymer Surface Interaction Studies
- Lubricants and Their Additives
- Molecular Junctions and Nanostructures
- Diamond and Carbon-based Materials Research
- Force Microscopy Techniques and Applications
- Advanced Polymer Synthesis and Characterization
- Anesthesia and Neurotoxicity Research
- Dendrimers and Hyperbranched Polymers
- Microstructure and mechanical properties
- Advanced battery technologies research
- Hydrogels: synthesis, properties, applications
- Orthopaedic implants and arthroplasty
- Aluminum Alloys Composites Properties
- Organic Chemistry Cycloaddition Reactions
- Proteoglycans and glycosaminoglycans research
- RNA Interference and Gene Delivery
- Aluminum Alloy Microstructure Properties
- Titanium Alloys Microstructure and Properties
- Silk-based biomaterials and applications
- Nuclear Receptors and Signaling
- Abdominal vascular conditions and treatments
Henan University Huaihe Hospital and Huaihe Clinical Institute
2025
Henan University
2014-2024
Aerospace Center Hospital
2022
State Key Laboratory of Vehicle NVH and Safety Technology
2022
Kaifeng University
2017
Henan University of Science and Technology
2016
Lanzhou Institute of Chemical Physics
2006-2008
Liaocheng University
2008
University of Chinese Academy of Sciences
2007
Nanosuspensions, as a new drug delivery system for insoluble drugs, are only composed of and small amount stabilizer, which is dispersed in an aqueous solution with high drug-loading, particle size, dispersion, large specific surface area. It can significantly improve the dissolution, bioavailability, efficacy drugs. In this study, paclitaxel nanosuspensions ((PTX)NS) were prepared by ultrasonic precipitation method, characteristics simple preparation easy repetition. With help homologous...
A natural polysaccharide-based nanogel has been synthesized and characterized as pH-sensitive drug delivery system for poorly water-soluble anticancer drugs. In this work, methacrylated hyaluronic acid (MAHA) was used to prepared degradable nanogels by a surfactant-free polymerization method in water, where 2,2-dimethacroyloxy-1-ethoxypropane (DMAEP) served pH labile cross-linker. Nanogels of different cross-linking density were doxorubicin (DOX) successfully encapsulated into the with...
A kind of N-containing borate ester (DEBE) with a double five-member-ring structure as lubricant additive was synthesized by using boric acid, diethanolamine and alkylphenol polyoxyethylene ether the starting materials.
Stimuli-responsive drug delivery systems (DDSs) are expected to realize site-specific release and kill cancer cells selectively. In this study, a pH-responsive micelle was designed utilizing the pH-sensitivity of borate bonds formed between dopamine boronic acid. First, methyl (polyethylene glycol)-block-polycaprolactone (mPEG-PCL) conjugated with 4-cyano-4-(thiobenzoylthio)pentanoic acid (CTP) obtain macroinitiator. Two different segments poly(dopamine methacrylamide) (PDMA)...
Apolipoprotein E4 (ApoE4) is the main genetic risk factor for Alzheimer's disease (AD), but exact way in which it causes AD remains unclear. Curcumin considered to have good therapeutic potential AD, its mechanism has not been clarified. This study aims observe effect of curcumin on ApoE4 transgenic mice and explore possible molecular mechanism. Eight-month-old were intraperitoneally injected with 3 weeks, Morris water maze test was used evaluate cognitive ability mice. Immunofluorescence...
Radiation-induced brain injury (RIBI) is a serious adverse effect of radiotherapy. RIBI has garnered considerable clinical attention owing to its powerful effects on function and cognition; however, no effective treatment available. The microbiota-gut-brain axis theory novel concept treating by regulating gut microbiota. Quercetin, particularly common flavonoid compound, wide range biological activities can regulate microbiota; it poor solubility dispersibility. In the present study, oral...
In this study, the structure-activity relationship of amphiphilic block copolymer micelles as nanosized drug delivery system was revealed. Firstly, a biodegradable triblock polymers PEG-DiHyd-PLA containing hydrazone bond synthesized through ring-opening polymerization. method, PEG-DiHyd-Phenol used initiator and L-lactide monomer. Then, polymeric were formed nano-drug carriers with pH sensitive. The structure composition polymer characterized by infrared (IR), nuclear magnetic resonance...
Coenzyme Q10 (CoQ10) is widely used in preventive or curative treatment of cardiovascular diseases. However, CoQ10 exhibits an extremely low solubility aqueous medium as well a poor oral bioavailability. Therefore, solanesyl poly(ethylene glycol) succinate (SPGS) and were formulated CoQ10-SPGS micelles with high content to improve the bioavailability rat. Findings indicate that, micelles, SPGS self-assembled into stable nanosized loading capacity more than 39%. The exhibit enhanced...
An amide-containing stratified self-assembled film is grafted on a silicon surface by simple two-step method. First, N-[3-(trimethoxylsilyl)propyl]ethylenediamine (DA) molecules are surfaces followed deriving with stearoyl chloride (STC) through coupling reaction. The films characterized means of contact angle measurement, ellipsometry, and attenuated total reflectance Fourier transformed infrared (ATR-FTIR) spectra. STC forms an ordered hydrophobic over the DA layer water nearly 110...
A peptide-containing alkylsilane self-assembled monolayer on silicon surface has been prepared successfully by a simple one-step strategy. The formation and structure of the SAMs were characterized means contact angle measurement, ellipsometry, FT-IR, AFM morphology observation. It was found that water content in hydrolysis solution plays key role determining quality monolayers. micro-tribological properties various films evaluated using AFM, while macro-tribological study performed...
Three kinds of amide-containing stratified self-assembled films are grafted onto silicon surfaces by a two-step method. (3-Aminopropyl)triethoxylsilane (APS), N-[3-(trimethoxylsilyl)propyl]ethylenediamine (DA), and N-[3-(trimethoxylsilyl)propyl]diethylenetriamine (TA) separately on to form the first layer followed derivatization with lauroyl chloride second via surface coupling reaction. The formation structure these characterized means contact angle measurement, ellipsometry, attenuated...
Lotus-leaf-like superhydrophobic surfaces have been prepared simply by surface texturing of porous silicon films with capillary stress and the mechanism was studied in detail.
Biodegradable pH-sensitive amphiphilic block polymer (mPEG-Hyde-PLGA) was synthesized via ring-opening polymerization, initiated from a hydrazone-containing macro-initiator. In this way, hydrazone bond inserted into the backbone of copolymer, linking hydrophilic poly(ethylene glycol) segment and hydrophobic poly(lactic-co-glycolic acid) segment. The copolymer self-assembled to form stable micelles with mean diameters below 100 nm served as drug delivery system for doxorubicin, loading...