A5054978012- Neonatal Respiratory Health Research
- Congenital Heart Disease Studies
- Congenital Diaphragmatic Hernia Studies
- Respiratory Support and Mechanisms
- Cardiovascular Conditions and Treatments
- Infant Development and Preterm Care
- Pharmacological Effects and Toxicity Studies
- Neuroscience of respiration and sleep
- Folate and B Vitamins Research
- Cardiac Arrest and Resuscitation
- Diphtheria, Corynebacterium, and Tetanus
- Mechanical Circulatory Support Devices
- Congenital heart defects research
- Infant Nutrition and Health
- Cardiovascular Function and Risk Factors
- Metabolism and Genetic Disorders
- Epilepsy research and treatment
- Pulmonary Hypertension Research and Treatments
- Neonatal and Maternal Infections
- Pneumonia and Respiratory Infections
- Airway Management and Intubation Techniques
- Metalloenzymes and iron-sulfur proteins
- Clinical Reasoning and Diagnostic Skills
- Cardiovascular Health and Risk Factors
- Neurological Complications and Syndromes
Klinik Hietzing
2003-2020
Mercy Hospital for Women
2007-2017
University of Teacher Education Lucerne
2014-2016
Charité - Universitätsmedizin Berlin
2006-2010
Deutsche Forschungsgemeinschaft
2005
Krankenhaus Waldfriede
1988
Abstract Necrotizing enterocolitis (NEC) is a severe, currently untreatable intestinal disease that predominantly affects preterm infants and driven by poorly characterized inflammatory pathways. Here, human murine NEC intestines exhibit an unexpected predominance of type 3/T H 17 polarization. In NEC, pro-inflammatory 3 NKp46 − RORγt + Tbet innate lymphoid cells (ILC3) are 5-fold increased, whereas ILC1 protective ILC3 obliterated. Both species dysregulation TLR repertoires, with TLR4 TLR8...
Objective Vitamin D may contribute to cardiovascular disease in the absence of hypercalcemia patients with chronic kidney disease. Methods We investigated effects long-term (6-week) treatment 1,25(OH)2D3, at a non-hypercalcemic dosage (0.25 μg/kg per day orally) 5/6 nephrectomized rats: (i) vehicle-treated, sham-operated rats; (ii) 1,25(OH)2D3-treated, (iii) and (iv) rats. Results Creatinine clearance after 6 weeks was significantly lower parathyroid hormone levels were higher...
Postnatal maturation of the immune system is poorly understood, as its impact on illnesses afflicting term or preterm infants, such bronchopulmonary dysplasia (BPD) and BPD-associated pulmonary hypertension. These are both cardiopulmonary inflammatory diseases that cause substantial mortality morbidity with high treatment costs. Here, we characterized blood samples collected from 51 infants longitudinally at five time points, 20 healthy birth age 3 to 16 weeks, 5 adults. We observed strong...
Aims This study aims to determine if there is a difference in the pharyngeal pressure, measured as surrogate for continuous positive distending airway delivered premature infants between two commonly used heated, humidified high‐flow nasal cannulae ( HHHFNC ) devices: F isher & P aykel H ealthcare and V apotherm 2000i. Methods Pharyngeal pressure measurements were taken from stable receiving respiratory support. Flow rates of 2–8 L/min studied. Results Nine had recorded with both devices...
Objective: To investigate the applicability, efficacy, and safety of single-pass albumin dialysis in children. Design: Retrospective data review uncontrolled clinical data. Setting: University-based pediatric intensive care unit collaborating with a local center for liver transplantation. Patients: Nine children, aged 2 to 15 yrs, who were treated acute failure various origins under compassionate-use protocol between 2000 2006. All patients met high-urgency transplantation criteria....
Sildenafil has been shown to preserve alveolar growth and lung angiogenesis in a rat model of bronchopulmonary dysplasia. We conducted proof-of-concept randomised controlled pilot study assess the feasibility oral sildenafil treatment extremely preterm infants with evolving dysplasia.Preterm <28 weeks gestational age were eligible if they mechanically ventilated on day 7 life. Infants 4-weeks course either (3 mg/kg/day) or placebo solution. Pre-discharge cardiorespiratory outcomes medication...
<b><i>Background:</i></b> Excessive ambient noise levels have been identified as a potential risk factor for adverse outcome in very preterm infants. Noise level measurements continuous positive airway pressure (CPAP) devices demonstrated that these constantly exceed current recommendations. The use of high-flow nasal cannula (HFNC) an alternative non-invasive ventilation modality has become more popular recent years neonatal care....
Summary Objective B‐type natriuretic peptide (BNP) has been shown to correlate with pulmonary hypertension (PH) in term neonates persistent of the newborn or congenital diaphragmatic hernia, and very preterm infants bronchopulmonary dysplasia. This study investigated potential association BNP N‐terminal‐pro‐BNP (NTproBNP) PH within first 72 hr life infants. Methods Preterm <32 weeks gestational age who received an echocardiogram were eligible. NTproBNP sampled at time echocardiogram....
Bronchopulmonary dysplasia (BPD) is often complicated by pulmonary hypertension (PH). We investigated three biomarkers potentially suitable as screening markers for extremely preterm infants at risk of BPD-associated PH. In this prospective observational cohort study conducted in a tertiary neonatal intensive care unit, 83 with BPD born <28-wk gestation and still inpatients 36-wk corrected age received an echocardiogram blood tests B-type natriuretic peptide (BNP), troponin I, YKL-40....
Heart rate is a well-established indicator of emotional arousal and can serve to detect events. One difficulty, however, in separating heart increases from those due physical activity. On-line analysis both activity (recorded with motion detectors) portable minicomputer may be able solve this problem. We have developed special algorithm that compares the values for particular minute previous minutes. If specific exceeds minutes without an accompanying increase activity, event possibly...
B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NTproBNP) have been shown to correlate with the size of patent ductus arteriosus (PDA) in preterm infants. We investigated whether BNP or NTproBNP was more closely correlated PDA size.This prospective observational study included infants born <32 weeks' gestation who had an echocardiogram performed within first four days life. Blood samples were taken simultaneously for measurements prior echocardiographic examination.Of 60 recruited,...
To study the impact on newborn behavioural states and accuracy of three infrared thermometers compared with digital axillary thermometer measurements in very low birth weight infants.Single-centre prospective observational study. Preterm infants born <1500-g were eligible. Infants observed for pre-measurement behaviour state using a five-point neonatal observation tool. One temperature was taken from each devices, followed by an measurement. Further behaviour-state observations recorded...
Herpes simplex virus hepatitis is a rare but potentially fatal condition that usually affects the immunocompromised, including pregnant women. This case report details course of fulminant hepatic failure in woman at 31 weeks gestation resulting emergent delivery fetus and liver transplant mother.
Unplanned extubation (UE) occurs as an infrequent complication of mechanical ventilation in the neonatal intensive care unit (NICU). Following UE, a trial noninvasive (NIV) may be considered if neonate is showing adequate respiratory effort. This study investigated success and failure rate NIV management neonates experiencing UE.Retrospective single-center UE NICU over 9-year period. Reintubation within 12 hours following was defined treatment failure. Short-term outcomes were analyzed for...
We report the uncommon clinical course of tetanus in a completely immunized 14-year-old boy. His initial symptoms, which included flaccid paralysis, supported diagnosis botulism. Preliminary mouse-test results with combined botulinum antitoxins A, B, and E, obtained from tetanus-immunized horses, backed this diagnosis. The change his paralysis to rigor negative, more specific, mouse test isolated nonvaccinated rabbits, disproved Tetanus was suspected despite complete vaccination. final...