A5004863855- Traditional Chinese Medicine Analysis
- Helicobacter pylori-related gastroenterology studies
- Pharmacological Effects of Natural Compounds
- Inflammatory mediators and NSAID effects
- Neuropeptides and Animal Physiology
- Nitric Oxide and Endothelin Effects
- Natural product bioactivities and synthesis
- Cancer, Lipids, and Metabolism
- Gastrointestinal motility and disorders
- Biochemical Analysis and Sensing Techniques
- Peroxisome Proliferator-Activated Receptors
- Ginseng Biological Effects and Applications
- Genomics, phytochemicals, and oxidative stress
- Inflammatory Bowel Disease
- Cancer Mechanisms and Therapy
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Bioactive Compounds and Antitumor Agents
- Alcohol Consumption and Health Effects
- Gastroesophageal reflux and treatments
- Immune cells in cancer
- Phytochemistry and Bioactive Compounds
- Plant-based Medicinal Research
- Calpain Protease Function and Regulation
- Medicinal Plant Pharmacodynamics Research
- Cancer, Stress, Anesthesia, and Immune Response
Korea University Medical Center
2023
Hong Kong Baptist University
2012-2022
University of Hong Kong
1994-2019
Jeonbuk National University
2013-2019
Chonbuk National University Hospital
2005-2017
Kowloon Hospital
2014
Chinese Medical Center
2010-2014
University of Ulsan
2012
Chinese University of Hong Kong
1994-2001
Samsung Medical Center
1998
Astragalus memebranaceus is used as immunomodulating agent in treating immunodeficiency diseases and to alleviate the adverse effects of chemotherapeutic drugs. In recent years, it has been proposed that may possess anti-tumorigenic potential certain cancer cell types. this study, anti-carcinogenic saponin extract were investigated HT-29 human colon cells tumor xenograft. Our findings have shown saponins (AST) inhibit proliferation through accumulation S phase G2/M arrest, with concomitant...
Astragalus membranaceus has been used to ameliorate the side effects of antineoplastic drugs because its immunomodulating nature. We had recently demonstrated that total saponins (AST) possess anticarcinogenic and proapoptotic properties in human colon cancer cells tumor xenograft. In this study, we identified NSAID-activated gene (NAG-1) as a potential molecular target AST. The growth-inhibitory AST were assessed panel cell lines. Hoechst 33342 nuclear staining, Annexin V-FITC/propidium...
Abstract Background Our ongoing research has revealed that total saponins extracted from the medicinal herb Radix Astragali (AST) exhibits significant growth-inhibitory and proapoptotic effects in human cancer cells. In present study, potential of AST controlling angiogenesis was further investigated with elaboration underlying molecular mechanism colon cell tumor xenograft. Results decreased protein level VEGF bFGF HCT 116 cells a time- dose-dependent manner. Among Akt/mTOR signal...
AIM:To investigate the protective effects of Astragalus membranaceus (Am) against hapten-induced colitis in male Sprague-Dawley rats as well its underlying mechanism. METHODS:Experimental was induced by enema administration 2,4-dinitrobenzene sulfonic acid (DNBS).Rats were either pretreated with Am extract (2 or 4 g/kg, p.o. once daily) starting from 10 d before DNBS enema, received post-treatment twice on three consecutive days following administration.Colonic lesion area and histological...
Conventional chemotherapy of liver cancer fails to provide satisfactory remission and may cause serious side effects, thus it is crucial derive alternative treatments that effectively inhibit cell growth with known mechanisms action. In the present study, we investigated anti-carcinogenic effects Coptis chinensis its major constituent, berberine, in HepG2 hepatocellular carcinoma (HCC) cells attempted elucidate underlying mechanism, including involvement nonsteroidal anti-inflammatory drug...
Abstract Background and Aim: Contemporary medications used in the treatment of gastric ulcers involve use novel mucosal protective drugs. The present study aimed to investigate gastroprotective effect ginger extract polaprezinc a rat model acetic acid‐induced ulcer. Methods: ‘Kissing’ were induced male Sprague‐Dawley rats by using 60% acid. Rhizoma Zingiber officinale (ginger) (1.5–5 g/kg) or (30 60 mg/kg) was orally given animals once daily for three consecutive days after ulcer induction....
We have previously demonstrated that the total saponins of Astragalus membranaceus (AST) possess potential anti-tumorigenic effects in human colon cancer cells and tumor xenografts. In present study, proapoptotic AST were investigated native cytokine-induced HT-29 to further unveil its mechanism action. Growth-inhibitory action (60 µg/ml) was cells, which exaggerated necrosis factor (TNF) (5 ng/ml)-induced cells. These accompanied by caspase 3 activation, cleavage poly(ADP-ribose) polymerase...
Pancreatic cancer is amongst the most lethal malignancies, while its poor prognosis could be associated with promotion of autophagy and tumor immune microenvironment. Studies have confirmed pro-tumorigenic nature cathelicidin family peptide LL-37 in several types cancer. However, at higher doses, exerts significant cytotoxicity against gastrointestinal cells. In our study, we investigated anti-tumorigenic potential pancreatic underlying mechanisms. Our results shown that inhibited growth...