A5101754218- Stroke Rehabilitation and Recovery
- Cancer-related molecular mechanisms research
- Cardiac Ischemia and Reperfusion
- Cardiac Imaging and Diagnostics
- MicroRNA in disease regulation
- Acute Ischemic Stroke Management
- Heart Rate Variability and Autonomic Control
- Botulinum Toxin and Related Neurological Disorders
- Cardiovascular and exercise physiology
- RNA modifications and cancer
- Cardiovascular Function and Risk Factors
- Angiogenesis and VEGF in Cancer
- Circular RNAs in diseases
- Corneal Surgery and Treatments
- Spinal Cord Injury Research
- Cardiac, Anesthesia and Surgical Outcomes
- Animal Genetics and Reproduction
- Pain Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Plant tissue culture and regeneration
- Virus-based gene therapy research
- Cardiac Health and Mental Health
- HIV/AIDS Research and Interventions
- Transcranial Magnetic Stimulation Studies
- Heart Failure Treatment and Management
Jiangsu Province Hospital
2015-2025
Nanjing Medical University
2016-2025
Soochow University
2025
Guang’anmen Hospital
2024-2025
Changshu No.1 People's Hospital
2012-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Xuzhou Medical College
2024
Tianjin University of Traditional Chinese Medicine
2024
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2024
Jiangsu Provincial Hospital of Traditional Chinese Medicine
2024
Immune functions decline with aging, leading to increased susceptibility various diseases including tumors. Exploring aging-related molecular targets in elderly patients cancer is thus highly sought after. Here we find that an ER transmembrane enzyme, sterol O-acyltransferase 2 (SOAT2), overexpressed regulatory T (Treg) cells from lung squamous cell carcinoma (LSCC), while radiomics analysis of LSCC associates SOAT2 expression reduced immune infiltration and poor prognosis. Mechanically, ex...
To investigate the possible role of microRNAs in resistance to platinum based chemotherapy non-small cell lung cancer (NSCLC), explore their potential and find biomarkers for prediction response platinum.21 miRNAs were deregulated A549/CDDP. Increased miR-21 expression significantly increased A549 platinum, whereas reduced decreased A549/CDDP cell. This finding was further validated tissue samples 58 patients it found that chemotherapy-resistant (n = 58, p 0.000). And associated with shorter...
Growing evidence has demonstrated exercise as an effective way to promote cardiovascular health and protect against diseases However, the underlying mechanisms of beneficial effects have yet be elucidated. Animal studies are widely used investigate key exercise-induced protection. standardized procedures well-established evaluation indicators for animal models needed guide researchers in carrying out effective, high-quality using prevent treat diseases. In our review, we present commonly...
Introduction The clinical study aimed to evaluate the levels of serum kisspeptin, NKB, and GABA in Chinese patients with polycystic ovary syndrome (PCOS) explore their association hormonal profiles, as well relationship between these PCOS controls.
With the recent surge in interest surrounding generative paradigms, recommendation has increasingly attracted attention of researchers community. This paradigm generally consists two stages. In first stage, pretrained semantic embeddings or collaborative ID are quantized to create item codes, aiming capture and preserve rich knowledge within these codes. The second stage involves utilizing discrete codes perform an autoregressive sequence generation task. Existing methods often either...
Cardiovascular disease is a leading cause of death, with ischemic heart being significant contributor. While percutaneous coronary intervention (PCI) effectively reduces mortality in myocardial infarction patients, its efficacy for unstable angina (UA) patients controversial. Complications associated PCI further limit application UA. RIC hypothesized to be an effective co-intervention that PCI-related complications and may potentially enhance the procedure itself. This pragmatic,...
Gastric cancer (GC) is a major global burden, and only HER2-targeted therapies have been approved in first line clinical therapy. CLDN18.2 has regarded as potential therapeutic target for gastrointestinal tumors, trials process. Hence, the precise, efficient, noninvasive detection of expression important effective application this attractive target. A high similarity protein sequence between CLDN18.1 -18.2 made RNA become more suitable expression. In study, molecular beacon (MB) with...
Heart failure is a continuously developing syndrome of cardiac insufficiency caused by diseases, which becomes major disease endangering human health as well one the main causes death in patients with cardiovascular diseases. The occurrence heart related to hemodynamic abnormalities, neuroendocrine hormones, myocardial damage, remodeling
Abstract: Multidrug resistance (MDR) is one of the major obstacles in successful chemotherapy. The combination chemotherapy drugs and multidrug-resistant reversing agents for treating MDR tumor a good strategy to overcome MDR. In this work, we prepared simple redox-responsive micelles based on mPEG-SS-C 18 as co-delivery system load paclitaxel (PTX) dasatinib (DAS) treatment MCF-7/ADR cells. co-loaded had dispersity spherical shape with uniform size distribution, they could quickly...
The present study investigated the efficacy of a computerized intervention for aphasia that combined speech-language and cognitive training delivered on an inpatient unit or via telerehabilitation to discharged patients. Forty patients were recruited randomly assigned group control group. Computerized was provided 14 days inpatients 30 Compared with group, had significantly more improved language function as assessed by Western Aphasia Battery (WAB) practical communication skills...
Objectives : N6-methyladenosine (m 6 A) is hypothesized to play a role in the regulation of pathogenesis myocardial infarction (MI). This study was designed compare m A-tagged transcript profiles identify mRNA-specific changes on pathophysiological variations after MI. Methods methylated RNA immunoprecipitation sequencing (MeRIP-seq) and (RNA-seq) were interacted select A-modified mRNAs with samples collected from sham operated MI rat models. A methylation regulated apoptosis/angiogenesis...
Lu X, Wu T, Huang P, Lin S, Qiu F, Meng XB, Gao J, Li JA: Effect and mechanism of intermittent myocardial ischemia induced by exercise on coronary collateral formation. Am J Phys Med Rehabil 2008;87:803–814. Objective: To hypothesize that appropriate could safely promote formation in the ischemic area through increased expression vascular endothelial growth factor (VEGF) its receptor fetal liver kinase-1 (Flk-1). Design: A balloon constrictor was surgically implanted first obtuse marginal...
Reinhardt, Jan D. PhD; Zheng, Yu MD; Xu, Guangxu Lu, Xiao MD, Yin, Yong Liu, Shouguo Gao, Qiang Xiong, Xianghu He, Chengqi Li, Hao DPT; Jianan MD Author Information