A5053815045- DNA Repair Mechanisms
- Carcinogens and Genotoxicity Assessment
- Effects and risks of endocrine disrupting chemicals
- MicroRNA in disease regulation
- Heavy Metal Exposure and Toxicity
- RNA Research and Splicing
- Cancer therapeutics and mechanisms
- Chromium effects and bioremediation
- Plant Genetic and Mutation Studies
- Prenatal Screening and Diagnostics
- Genetically Modified Organisms Research
- Chemotherapy-induced organ toxicity mitigation
- Toxic Organic Pollutants Impact
- PARP inhibition in cancer therapy
- Cancer-related Molecular Pathways
- Cholesterol and Lipid Metabolism
- RNA modifications and cancer
- Sexual Differentiation and Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Nanjing Normal University
2018-2020
Bharathiar University
2010-2016
Cisplatin, commonly used in a variety of cancer treatments, induces apoptosis cells by causing lethal DNA damage. Several repair pathways participate regulation cisplatin treatment, leading to sensitivity or resistance cells. polymerase β (pol β), key protein involved base excision repair, confers response therapy that is dependent on activity. Pol D160G mutation with enhanced activity, previously identified clear cell renal carcinoma, enhances the human and mouse xenografts limiting...
Sexual ambiguity commonly known as intersexuality, is a condition of imperfect sexual differentiation between male and female. The present study was aimed at analyzing the chromosomal abnormalities intersex subjects in Coimbatore city, India Of 30 cases studied, 10 them were genetically (46,XY) but phenotypically females, 8 female (46,XX) with maleness, 4 had 45,X/47,XXY, 6 46,XX/46,XY mosaic type 3 46,XY, del(Yq). results are discussed light recent literature.
Gold jewelry workers are occupationally exposed to nitric oxide (NO) during the purification of gold. The present study involves evaluations chromosome aberrations (CA), micronucleus (MN) and comet assay in lymphocytes identifies influence polymorphisms DNA repair genes (XRCC1280Arg/His, XRCC1399Arg/Gln) among gold (NO). Among 84 samples undertaken for study, non-exposed (categorized based only on age being group I <35years; II ≥35 years) subjects work duration) constituted 42 each. With...
<p>Supplementary Table 1: DNA substrates for pol β activity and BER assays Supplementary 2: Salt bridges of WT D160G protein 3: Primers mutant sequence XPA knock down Figure 1. SDS-PAGE the β. Proteins were purified by Ni-NTA column from E. coli. 2. ELISA tested same amount precoated on microtiter plates in DNA-binding assay. 3. Western blot analysis polβ levels 786-0 cells. Similar wild-type used assays. 4. Real-time PCR mRNA cell (A) MCF-7 (B). Data represent mean {plus minus}SD....
<div>Abstract<p>Cisplatin, commonly used in a variety of cancer treatments, induces apoptosis cells by causing lethal DNA damage. Several repair pathways participate regulation cisplatin treatment, leading to sensitivity or resistance cells. polymerase β (pol β), key protein involved base excision repair, confers response therapy that is dependent on activity. Pol D160G mutation with enhanced activity, previously identified clear cell renal carcinoma, enhances the human and mouse...
<p>Supplementary Table 1: DNA substrates for pol β activity and BER assays Supplementary 2: Salt bridges of WT D160G protein 3: Primers mutant sequence XPA knock down Figure 1. SDS-PAGE the β. Proteins were purified by Ni-NTA column from E. coli. 2. ELISA tested same amount precoated on microtiter plates in DNA-binding assay. 3. Western blot analysis polβ levels 786-0 cells. Similar wild-type used assays. 4. Real-time PCR mRNA cell (A) MCF-7 (B). Data represent mean {plus minus}SD....
<div>Abstract<p>Cisplatin, commonly used in a variety of cancer treatments, induces apoptosis cells by causing lethal DNA damage. Several repair pathways participate regulation cisplatin treatment, leading to sensitivity or resistance cells. polymerase β (pol β), key protein involved base excision repair, confers response therapy that is dependent on activity. Pol D160G mutation with enhanced activity, previously identified clear cell renal carcinoma, enhances the human and mouse...