A5102803381- Meningioma and schwannoma management
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Air Quality and Health Impacts
- Bone Tumor Diagnosis and Treatments
- Cancer Cells and Metastasis
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Kruppel-like factors research
- Cancer-related Molecular Pathways
- Assisted Reproductive Technology and Twin Pregnancy
- Cerebrovascular and Carotid Artery Diseases
- PARP inhibition in cancer therapy
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neuroblastoma Research and Treatments
- Facial Nerve Paralysis Treatment and Research
- Genetic and Kidney Cyst Diseases
- Cervical Cancer and HPV Research
- Vascular Malformations Diagnosis and Treatment
- Climate Change and Health Impacts
- Maternal and fetal healthcare
- Autophagy in Disease and Therapy
Zunyi Medical University
2025
Affiliated Hospital of Nantong University
2025
Nantong University
2011-2025
First Affiliated Hospital of Kunming Medical University
2020-2024
Kunming Medical University
2020-2024
Shandong First Medical University
2024
Shandong Tumor Hospital
2024
Women's Hospital, School of Medicine, Zhejiang University
2022-2024
Qingdao University
2008-2024
Yuhuangding Hospital
2023-2024
Low-dose CT (LDCT) is currently used in lung cancer screening of high-risk populations for early diagnosis. However, 96% individuals with detected nodules are false positives.In order to develop an efficient predictor from clinical, demographic and LDCT features, we studied a total 218 subjects or benign nodules. Probabilistic graphical models (PGMs) were integrate demographics, clinical data features 92 (training cohort) the Pittsburgh Lung Screening Study cohort.Learnt PGMs identified...
Growing evidence has demonstrated exercise as an effective way to promote cardiovascular health and protect against diseases However, the underlying mechanisms of beneficial effects have yet be elucidated. Animal studies are widely used investigate key exercise-induced protection. standardized procedures well-established evaluation indicators for animal models needed guide researchers in carrying out effective, high-quality using prevent treat diseases. In our review, we present commonly...
Abstract Acute lymphoblastic leukemia (ALL) with distinct fusion transcripts has unique clinical features. In this study, the incidence, characteristics, early treatment response, and outcomes of 1,004 Chinese pediatric ALLs were analyzed. Patients TEL‐AML1 E2A‐PBX1 genes or other B cell precursor (BCP‐ALL) had favorable features, sensitive to prednisone, low minimal residual disease (MRD), an excellent prognosis, a 5‐year event‐free survival (EFS) 84–92%. T‐ALL was associated high WBC,...
Neuroinflammation is a crucial factor contributing to neurological injuries after intracerebral hemorrhage (ICH). C1q/TNF-related protein 9 (CTRP9), an agonist of adiponectin receptor 1 (AdipoR1), has recently been shown reduce inflammatory responses in systemic diseases. The objective this study was investigate the protective role CTRP9 against neuroinflammation ICH mouse model and explore contribution adenosine monophosphate-activated kinase (AMPK)/nuclear kappa B (NFκB) pathway...
Pulmonary sclerosing pneumocytoma (PSP) is a relatively rare benign lung tumor, and it difficult to obtain an accurate diagnosis before surgery. Herein, we present case of 34-year-old woman who came our hospital for medical help due cough sputum one month. She underwent chest computed tomography (CT) scan which revealed circular soft tissue density shadow in the upper lobe left lung. A needle biopsy was subsequently performed probable carcinoid. To further evaluate nature mass determine...
Objective The Rotterdam computed tomography (CT) score was used to evaluate the degree of coma and prognosis patients with moderate severe craniocerebral injury, analyze its feasibility, assess value in guiding further clinical applications. Methods A total 120 moderate-to-severe injuries were selected as study participants, all whom treated at Department Neurosurgery Second Affiliated Hospital Nantong University. All underwent CT scans. Glasgow Coma Scale coma, Outcome prognosis. scores...
It was previously reported that poly‑(adenosine diphosphate‑ribose) polymerase‑1 (PARP‑1) regulated ionizing radiation (IR)‑induced autophagy in CNE‑2 human nasopharyngeal carcinoma cells. The present study aimed to investigate whether PARP‑1‑mediated IR‑induced occurred via activation of the liver kinase B1 (LKB1)/adenosine monophosphate‑activated protein (AMPK)/mammalian target rapamycin (mTOR) signaling pathway In addition, effect PARP‑1 and AMPK inhibition on sensitization cells...
To explore the therapeutic effects of early enteral nutrition (EEN) on patients with sepsis mechanical ventilation.Patients ventilation in medical intensive care unit (ICU) from January 2013 to March 2016 were treated nutrition. Patients within 48 hours initiation assigned EEN group, and rest delayed (DEN) group. Peripheral blood Th17 cells Treg cells, endotoxin (ET) level, 28-day mortality, duration ventilation, lengths ICU stay hospital stay, incidence ICU-acquired weakness (ICU-AW)...
It has been demonstrated that miR‑222 is upregulated in human intervertebral disc (IVD) degeneration tissues; however, the underlying mechanisms remain unclear. In this study, we aimed to elucidate of action IVD tissues. Nucleus pulposus (NP) cells were treated with lipopolysaccharide (LPS) simulate degeneration. The expression level was detected by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and Cell apoptosis analyzed flow cytometry. Additionally, western blot...
Evidence regarding the effects of long-term and high-level ambient air pollution exposure on cardiac conduction systems remains sparse.To investigate associations to abnormalities in Chinese adults explore susceptibility characteristics.In 2017, a total 27,047 participants aged 18-80 years were recruited from baseline survey Cohort Study Chronic Disease Communities Natural Population Beijing, Tianjin Hebei (CHCN-BTH). The three year (2014-2016) average pollutant concentrations assessed by...
Human papillomaviruses (HPVs) replicate only in differentiated squamous epithelia warts and epithelial raft cultures grown at the medium-air interface. Virus-encoded host transcription factors are thought to be responsible for repressing viral enhancer promoter located within upstream regulatory region (URR) undifferentiated basal parabasal cells while up-regulating their activities spinous cells. Using recombinant retroviruses, we acutely transduced neonatal foreskin keratinocytes (PHKs)...
Immune checkpoint inhibitor (ICI) has become pivotal in the treatment of advanced lung cancer, yet absence reliable biomarkers for assessing response poses a significant challenge. This study aims to explore predictive value various lymphocyte subsets different cancer subtypes, thus potentially identifying novel improve ICI stratification and outcomes.
Targeting neuronal apoptosis after intracerebral hemorrhage (ICH) may be an important therapeutic strategy for ICH patients. Emerging evidence indicates that C1q/TNF-Related Protein 9 (CTRP9), a newly discovered adiponectin receptor agonist, exerts neuroprotection in cerebrovascular disease. The aim of this study was to investigate the anti-apoptotic role CTRP9 experimental and explore underlying molecular mechanisms. induced mice via intrastriatal injection bacterial collagenase....
The disruption of the blood brain barrier (BBB) is key factor leading to neurological impairment after intracerebral hemorrhage (ICH) injury. Adiponectin receptor 1 (AdipoR1) has an important effect contributing integrity BBB. As a homologue adiponectin, recombinant C1q/TNF-related protein 9 (rCTRP9) neuroprotective in cerebrovascular diseases. aim this study was investigate protective AdipoR1 activation with rCTRP9 on BBB ICH injury and potential mechanisms.177 male mice were subjected...
In this study, a series of novel N-(piperidine-4-yl)benzamide derivatives was designed, synthesized, and evaluated for antitumor activity. Some compounds were found to have potent particular, compound 47 showed the most biological activity against HepG2 cells, with an IC50 value 0.25 μm. Western blot analysis demonstrated that inhibited expression cyclin B1 p-Rb enhanced p21, p53, Rb, phospho-adenosine monophosphate-activated protein kinase (p-AMPK). Further, cell cycle arrest observed by...
To summarize the characteristics and long-term outcomes of olfactory neuroblastoma through analysis 13 cases in single institution, with assessment treatment modality, prognostic factors.A retrospective study thirteen diagnosed as underwent combined treatments during period 2000-2010. Statistical was performed to search for factors compared different modalities.13 patients were enrolled this study, including 8 male 5 female, ranging from 15 69 (median 43) years old. One patient at stage A...
Abstract The radioresistance of nasopharyngeal carcinoma ( NPC ) may be related to cancer stem cells CSC s), and the characteristics s maintained by telomerase activity. In this study, we explored ‐like activity radioresistant cell line CNE ‐2R. This work provides a foundation for future studies on cell‐targeted therapies targeting . expression cell‐related genes/proteins hTERT gene/protein in ‐2R its parent radiosensitive ‐2 were detected using qPCR /Western Blot. Label‐retaining LRC s)...
To date, little is known regarding the molecular mechanisms underlying deregulation of giant cell tumor bone (GCTB). Hypoxia has been confirmed to be a characteristic observed in variety types cancer, and pivotal role for hypoxia‑inducible factor-1α (HIF‑1α) previously indicated hypoxia adaptation GCTBs. However, another key regulator, microRNA (miR)‑210, which closely correlated with HIF‑1α, not identified The present study therefore selected miR‑210, most significantly upregulated miRNA...
Valproate sodium (VPA) is a traditional antiepileptic drug with neuroprotective role in cerebrovascular disease. After intracerebral hemorrhage (ICH), mechanical compression by hematoma, neuroinflammation, oxidative stress, and cytotoxicity of hematoma lysates caused the destruction blood brain barrier (BBB). Targeting BBB major therapeutic method for patients ICH. The purpose present study was to explore VPA preserving integrity ICH model investigate underlying molecular mechanisms. One...