A5006649569- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- Phagocytosis and Immune Regulation
- Immune Cell Function and Interaction
- Ubiquitin and proteasome pathways
- Lung Cancer Research Studies
- Atherosclerosis and Cardiovascular Diseases
- Neuroendocrine Tumor Research Advances
Nantong University
2022-2025
Nantong Science and Technology Bureau
2023
Immune functions decline with aging, leading to increased susceptibility various diseases including tumors. Exploring aging-related molecular targets in elderly patients cancer is thus highly sought after. Here we find that an ER transmembrane enzyme, sterol O-acyltransferase 2 (SOAT2), overexpressed regulatory T (Treg) cells from lung squamous cell carcinoma (LSCC), while radiomics analysis of LSCC associates SOAT2 expression reduced immune infiltration and poor prognosis. Mechanically, ex...
Background: Nicotinamide mononucleotide (NMN) is the physiological circulating NAD precursor thought to elevate cellular level of NAD+ and ameliorate various age-related diseases. An inseparable link exists between aging tumorigenesis, especially involving aberrant energetic metabolism cell fate regulation in cancer cells. However, few studies have directly investigated effects NMN on another major ageing-related disease: tumors. Methods: We conducted a series mouse models evaluate...
Serpin family A member 1 (SERPINA1) encodes a protease inhibitor participating in many human diseases, but its value immunoregulation and prognosis of cancers remains unclear. In this study, through comprehensive analysis data from The Cancer Genome Atlas (TCGA) datasets, we found that SERPINA1 was dysregulated compared with normal tissues. expression significantly associated prognosis, immune subtype, molecular checkpoint (ICP) genes, tumor mutational burden (TMB), microsatellite...
Purpose: Elucidation of the potential value ribosomal protein S27a (RPS27A) for prognosis and immunotherapy in pan-cancer analysis, exploration oncogenic function RPS27A on hepatocellular carcinoma (HCC) macrophage polarization. Methods: A systematic analysis mechanism was conducted with R software multiple public platforms, including UALCAN, HPA, TISIDB, TIMER, cBioPortal, cancerSEA, TIDE, TIMSO databases. The expression human mouse liver detected by immunohistochemistry. biological...
Although the etoposide and carboplatin (EP) combination strategy has been first-line chemotherapy, patients with extensive-stage disease small-cell lung cancer (SCLC) still have poor survival outcomes. Our retrospective analysis revealed that 46 SCLC only achieved medium overall (OS) of 11.6 months after treated by EP. Recently, it was demonstrated therapy PD1/PD-L1 immune checkpoint blocker EP could significantly improve OS patients. However, serious treatment-related toxicity leaded to a...
The progression of hepatoma is heavily influenced by the microenvironment. Tumor-associated macrophages (TAMs) are considered to play a critical role in tumor microenvironment (TME) and increase aggressiveness hepatoma. activation hepatic stellate cells (HSCs) involved progression, accumulating evidence demonstrates change microRNA (miRNA) expression during HSC activation. Therefore, potential roles HSCs-related miRNAs macrophage differentiation deserve be explored. present study aimed...