A5089751962- Extracellular vesicles in disease
- Sperm and Testicular Function
- Urologic and reproductive health conditions
- Dysphagia Assessment and Management
- Tracheal and airway disorders
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Chronic Lymphocytic Leukemia Research
- Tissue Engineering and Regenerative Medicine
- Voice and Speech Disorders
- Liver Disease Diagnosis and Treatment
- Circular RNAs in diseases
- Mesenchymal stem cell research
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Nerve injury and regeneration
- Spinal Cord Injury Research
- Analytical chemistry methods development
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- IoT-based Smart Home Systems
- Proteoglycans and glycosaminoglycans research
- Histone Deacetylase Inhibitors Research
- Mobile Ad Hoc Networks
- Drug Transport and Resistance Mechanisms
Zhejiang Chinese Medical University
2024
Third Affiliated Hospital of Sun Yat-sen University
2020-2023
Sun Yat-sen University
2020-2023
Air Force Medical University
2023
Northwest University
2023
Tongji University
2019-2022
Nantong University
2018-2022
Northwest Women's and Children's Hospital
2021
Yantai Institute of Coastal Zone Research
2020
Chinese Academy of Sciences
2020
Nerve regeneration in adult mammalian spinal cord is poor because of the lack intrinsic neurons and extrinsic factors - glial scar triggered by injury inhibits or promotes regeneration. Recent technological advances spatial transcriptomics (ST) provide a unique opportunity to decipher most genes systematically throughout formation, which remains poorly understood. Here, we first constructed tissue-wide gene expression patterns mouse cords over course formation using ST after from 32 samples....
Abstract Background There is a lack of biomarkers for distinguishing non-obstructive azoospermia (NOA) patients with successful sperm retrieval (Sp+) from those failed (Sp-). This study aimed to determine the potential extracellular vesicles tRNA-derived small RNA (tsRNA) as novel non-invasive biomarker by microdissection testicular extraction (mTESE). Methods The included 18 NOA and 23 (Sp-), 15 obstructive (OA) patients, 5 idiopathic oligospermia (IO) 12 healthy people. Seminal plasma...
Glial cells play an important role in signal transduction, energy metabolism, extracellular ion homeostasis and neuroprotection of the central nervous system. However, few studies have explained potential effects exosomes from glial on system health disease. In this study, genes expressed astrocytes microglia were identified by deep RNA sequencing. Kyoto Encyclopedia Genes Genomes analysis indicated that several pathways these are responsible for promoting neurodegenerative diseases,...
Cervical cancer is the fourth most common among women worldwide in terms of both incidence and mortality. Persistent infection with high-risk human papillomavirus (HPV) has been identified as a cause cervical intraepithelial neoplasia invasive cancer. The distribution genotypes varies regionally. To acquire baseline data on population-based prevalence genotype HPV infection, we investigated molecular epidemiology Xi'an, China. study was conducted from September 2018 to December 2020. A total...
Objectives: Investigate the biomechanical characteristics in tracheostomized patients with aspiration following acquired brain injury (ABI) and further explore relationship between aspiration. Methods: This is a single-center cross-sectional study. The ABI age-matched healthy controls were recruited. characteristics, including velopharynx (VP) maximal pressure, tongue base (TB) upper esophageal sphincter (UES) residual UES relaxation duration, subglottic examined by high-resolution manometry...
// Yanyan Li 1 , Yuan Hu Chuanjin Liu Qingyue Wang Xiaoxiao Han Yong Xue-Shun Xie Xiong-Hui Chen 2 Xiang 3 Eric R. Siegel 4 Kambiz Afrasiabi 5 Mark E. Linskey You-Xin Zhou Yi-Hong 1,5,6 Neurosurgery & Brain and Nerve Research Laboratory, Department of Emergency Surgery, The First Affiliated Hospital Soochow University, Suzhou, Jiangsu, China Neuroepigenetic Reseach Lab, Queensland Institute, University Queensland, St Lucia, QLD, Australia Biostatistics, Arkansas for Medical Sciences, Little...
Objective Aspiration is a common complication after tracheostomy in patients with acquired brain injury (ABI), resulting from impaired swallowing function, and which may lead to aspiration pneumonia. The Passy-Muir Tracheostomy Ventilator Swallowing Speaking Valve (PMV) has been used enable voice reduce aspiration; however, its mechanism unclear. This study aimed investigate the mechanisms underlying beneficial effects of PMV intervention on prevention aspiration. Methods A randomized,...
Since its release in 2007 by the HART Communication Foundation, WirelessHART plays an important role industrial process control and monitoring. Many devices are battery-powered it is hard to replace batteries harsh environments, hence wireless networks that achieve long network lifetimes demanded many settings. The lifetime of a negatively affected uneven premature energy depletion individual nodes, so good manager should route packages way such nodes depletes at even pace. This paper...
Objective Activation of sympathetic tone is important for cartilage degradation in osteoarthritis (OA). Recent studies reported that signals can affect the mitochondrial function target cells. It unknown whether this effect exits chondrocytes and affects chondrocyte catabolism. The contribution dynamics activation α2-adrenergic signal-mediated catabolism was investigated study. Design Primary were stimulated with norepinephrine (NE) alone, or pretreated an receptor (Adra2) antagonist...
<p indent=0mm>Molecular imprinting is a technique to synthesize molecularly imprinted polymers (MIPs) with specific and selective recognition ability for given template molecule. As molecular component, MIPs combined highly sensitive fluorescent detection construct imprinting-based fluorescence sensors (MI-FL sensors), which have attracted much attention in the field of trace environmental organic pollutants. According expression emission signal, this review introduces various strategies...
ABT-199 (venetoclax) is a BCL-2 suppressor with pronounced effects on acute myeloid leukemia (AML). However, its usefulness as monotherapy or in combination hypomethylating medicines like azacitidine debatable due to acquired resistance. Usnic acid, dibenzofuran extracted from lichen Usnea diffracta Vain, exhibits anticancer properties and may counteract multidrug resistance cells.
Abstract Adult regeneration in spinal cord is poor mammalian but remarkable the neonatal mammals and some vertebrates, including fish salamanders. Increasing evidences basis of this interspecies ontogeny highlighted pivotal roles neuron extrinsic factors-the glial scar, which exert confusing inhibiting or promoting function, spatiotemporal ordering cellular molecular events that drive repair processes scar formation remains poorly understood. Here, we firstly constructed tissue-wide gene...
Myeloid differentiation factor 88 (MYD88) is a key linker in the Toll-like receptor (TLR) signaling pathway, which plays an important role progression of tumour. Recent studies have shown that activating mutation MYD88 L265P has been identified about 90% lymphoplasmacytic lymphoma/Waldenstrom's macroglobulinemia and 40% diffuse large B-cell lymphoma other subtypes proliferative neoplasms. Different types neoplasms their own histology, immunohistochemistry clinical characteristics, thus,...
目的 探讨伴MYD88L265P基因突变B细胞幼淋巴细胞白血病（B-PLL）的临床特点、诊断、鉴别诊断及治疗方案。 方法 回顾性分析江苏省盐城市第一人民医院1例伴MYD88L265P突变B-PLL患者的临床资料，并复习相关文献。 结果 患者为老年男性，临床主要表现为脾大、浆膜腔积液，根据血象、骨髓细胞学、免疫表型、基因突变检测（TP53、MYD88L265P等）明确诊断。采用苯丁酸氮芥、氟达拉滨、依布替尼等药物治疗。 结论 伴MYD88L265P突变的B-PLL临床罕见，易误诊、漏诊，Bruton酪氨酸激酶（BTK）抑制剂的使用为B-PLL治疗带来希望。
Objective To investigate the effect of a Passy-Muir speaking valve (PMV) on biomechanics swallowing and aspiration among persons tracheotomized after brain damage. Methods Twenty patients with injury were selected randomly divided into non-PMV intervention group PMV group, each 10. Both groups given routine training, while was additionally provided trained to use it. The treatment ended when tracheal tube removed or 2 weeks. High-resolution manometry videofluoroscopy used evaluate...