A5045913363- 3D Printing in Biomedical Research
- Additive Manufacturing and 3D Printing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Quantum Information and Cryptography
- Advanced MEMS and NEMS Technologies
- Mechanical and Optical Resonators
- Advanced Computational Techniques and Applications
- Advanced DC-DC Converters
- Product Development and Customization
- Reproductive Biology and Fertility
- Neural Networks and Reservoir Computing
- Induction Heating and Inverter Technology
- Industrial Technology and Control Systems
- Hydraulic Fracturing and Reservoir Analysis
- Cellular Mechanics and Interactions
- Pluripotent Stem Cells Research
- Advanced Memory and Neural Computing
- Neuroscience and Neural Engineering
- Analog and Mixed-Signal Circuit Design
- Acoustic Wave Resonator Technologies
- Electrodeposition and Electroless Coatings
- Power Transformer Diagnostics and Insulation
Ningbo University
2021-2024
Zhejiang University
2007-2024
Southern University of Science and Technology
2024
North China Electric Power University
2024
Research Institute of Petroleum Exploration and Development
2023
University of Science and Technology Beijing
2023
Academic Degrees & Graduate Education
2022
Institute of Modern Physics
2022
Suzhou Municipal Hospital
2020
National Engineering Research Center of Electromagnetic Radiation Control Materials
2020
Photo-crosslinkable gelatin methacrylate (GelMA) has become an attractive ink in 3D printing due to its excellent biological performance. However, limited by low viscosity and long cross-linking time, it is still a challenge directly print GelMA extrusion-based printing. Here, balance the printability biocompatibility, biomaterial composed of nanoclay was specially designed. Using this ink, complex scaffolds with high shape fidelity can be easily printed based on thixotropic property...
Three-dimensional (3D) bioprinting of soft large-scale tissues in vitro is still a big challenge due to two limitations, (i) the lack an effective way print fine nutrient delivery channels (NDCs) inside cell-laden structures above millimetre level; (ii) need for feasible strategy vascularize NDCs. Here, novel 3D method reported directly with effectively vascularized Bioinks desired tissue cells and endothelial (ECs) are separately simultaneously printed from outside (mixed GelMA) gelatin)...
The use of microscale fibers could facilitate nutrient diffusion in fiber-based tissue engineering and improve cell survival. However, order to build a functional mini such as muscle fibers, nerve conduits, blood vessels, hydrogel microfibers should not only mimic the structural features native tissues but also offer cell-favorable environment sufficient strength for functionalization. Therefore, an important goal is fabricate morphology-controllable with appropriate materials complexity...
Cell-scaffold interactions have drawn significant attention in tissue engineering. In this study, we define a heterogeneous scaffold, which can be customized with respect to gradient strength, variable fiber diameter, and pore sizes. Heterogeneous scaffolds ultrafine fibers (3–22 μm diameter) printed via high-resolution melt electrowriting (MEW) using only one nozzle by adjusting the printing parameters. With precise control of diameter deposited fibers, complex patterns, such as star, Tai...
Abstract Low‐concentration gelatin methacryloyl (GelMA) has excellent biocompatibility to cell‐laden structures. However, it is still a big challenge stably fabricate organoids (even microdroplets) using this material due its extremely low viscosity. Here, promising electro‐assisted bioprinting method developed, which can print low‐concentration pure GelMA microdroplets with cost, cell damage, and high efficiency. With the help of electrostatic attraction, uniform measuring about 100 μm are...
Abstract Hydrogel microspheroids are widely used in tissue engineering, such as injection therapy and 3D cell culture, among which, heterogeneous drawing much attention a promising tool to carry multiple types separated phases. However, it is still big challenge fabricate that can reconstruct built‐up tissues' microarchitecture with excellent resolution spatial organization limited sizes. Here, novel airflow‐assisted bioprinting method reported, which print versatile spiral...
Triply periodic minimal surfaces (TPMS) - based porous structures have been universally adopted for mimicking the properties of bone scaffolds due to their interconnected geometries with smooth and controllable pores. To further increase versatility controllability, an enhanced scaffold on TPMS is proposed. The pores different sizes are designed onto three types TPMS-based then additively manufactured through laser powder bed fusion (LPBF). investigate manufacturability, various approaches...
Abstract Maintaining an adequate supply of nutrients/oxygen is a major challenge in the biofabrication large tissue constructs. However, building preformed nutrient networks may be effective strategy for engineering thick tissues. Here, novel way bioprinting large‐scale constructs with intentional presented. A special nozzle developed which can print bioink and sacrificial ink half synchronously single filament. Nutrient these bioprinted are formed by subsequently dissolving away gelatin,...
The field of how to rapidly assemble microfluidics with modular components continuously attracts researchers' attention, however, extra efforts must be devoted solving the problems leaking and aligning between individual modules. This paper presents a novel type microfluidic device, driven by capillary force. There is no necessity for strict seal or special alignment, its open structures make it easy integrate various stents reactants. key rationale this method print different functional...
Abstract Hydrogel microfibers have many fascinating applications as microcarriers for drugs, factors, and cells, such 3D cell culture, building micro‐organoids, transplantation therapy due to their simple structures. It is unknown whether cell‐laden fiber can become a standard‐use product like woundplast. Here, from the technical practical view, elements required user‐oriented are first discussed: i) materials used should promote functionalization be easily processed; ii) follow...
Abstract Hydrogel microspheres are flexible microstructures with many fascinating functions, such as three-dimensional cell culture, injection therapy, drug delivery, organoids and microtissues construction. The traditional methods of manufacturing hydrogel more or less have some shortcomings, atomization/emulsion method uneven sizes; piezoelectric-/thermal-/electric-assisted inkjet high damage unknown growth effects; microfluidic sophisticated microdevices etc, which lead to poor user...
In hydrogel-based tissue engineering, channel network is an efficient structure for transporting nutrients/oxygen to support cell survival and construct living tissues in vitro. 3D printing can create complex constructs, however, due the weak mechanical properties of hydrogel bioinks, cell-laden constructs with effective networks are difficult be directly printed. Here, easy sacrificial method based on commercial desktop printer water-soluble polyvinyl alcohol (PVA) introduced. Specifically,...
Gelatin methacryloyl (GelMA) has become a popular biomaterial in the field of bioprinting. The derivation this material is gelatin, which hydrolyzed from mammal collagen. Thus, arginine-glycine-aspartic acid (RGD) sequences and target motifs matrix metalloproteinase (MMP) remain on molecular chains, help achieve cell attachment degradation. Furthermore, formation properties GelMA are versatile. methacrylamide groups allow to rapidly crosslinked under light irradiation presence...
Blood banking has a broad public health impact influencing millions of lives daily. It could potentially benefit from emerging biopreservation technologies. However, although vitrification shown advantages over traditional cryopreservation techniques, it not been incorporated into transfusion medicine mainly due to throughput challenges. Here, we present scalable method that can vitrify red blood cells in microdroplets. This approach enables the large volumes short amount time, and makes...
Aim: Oocyte cryopreservation remains largely experimental, with live birth rates of only 2–4% per thawed oocyte. In this study, we present a nanoliter droplet technology for oocyte vitrification. Materials & methods: An ejector-based vitrification system was designed to continuously cryopreserve oocytes in droplets. survival rates, morphologies and parthenogenetic development after each step were assessed comparison fresh oocytes. Results: Oocytes retrieved cryoprotectant agent...
Anisotropic tissues in vivo have special structural characteristics and biological functions. Nowadays, bioprinting is widely used tissue engineering an effective way to process cell-laden hydrogels. However, the direct of oriented hydrogel structures engineer anisotropic still difficult. Meanwhile, inherent dense micropore network after gelation hydrogel-based bioinks usually limits normal growth encapsulated cells due inadequate supply nutrient/oxygen. Herein, we proposed a pre-shear...
A running transformer frequently experiences interturn faults; they are typically difficult to detect in their early stages but eventually progress short circuits, which cause damage the transformer. Therefore, finding out fault mechanism of full process can provide a theoretical basis for detection. In this paper, an electromagnetic-solid mechanics coupled finite element model consistent with actual oil-immersed three-phase is established. The transient winding from discharge circuit...
Embedded 3D bioprinting techniques have emerged as a powerful method to fabricate engineered constructs using low strength bioinks; however, there are challenges in simultaneously satisfying the requirements of high-cell-activity, high-cell-proportion, and low-viscosity bioinks. In particular, printing capacity embedded is limited two main challenges: spreading diffusion, especially for liquid, high-cell-activity bioinks that can facilitate high-cell-proportion. Here, liquid-in-liquid...