Ke Zhang

ORCID: 0000-0003-3090-1371
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About
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Research Areas
  • Tracheal and airway disorders
  • Neonatal and fetal brain pathology
  • Liver Disease and Transplantation
  • Pregnancy and preeclampsia studies
  • Cardiac Imaging and Diagnostics
  • HIV/AIDS Research and Interventions
  • HIV Research and Treatment
  • Dysphagia Assessment and Management
  • Biological and pharmacological studies of plants
  • Gut microbiota and health
  • Inflammatory Bowel Disease
  • Electrochemical sensors and biosensors
  • Cleft Lip and Palate Research
  • Sexual Differentiation and Disorders
  • Eicosanoids and Hypertension Pharmacology
  • Organ Transplantation Techniques and Outcomes
  • Medical Research and Treatments
  • Cholinesterase and Neurodegenerative Diseases
  • Mycobacterium research and diagnosis
  • Fiscal Policies and Political Economy
  • Long-Term Effects of COVID-19
  • Maternal Mental Health During Pregnancy and Postpartum
  • Botulinum Toxin and Related Neurological Disorders
  • Medicinal Plant Pharmacodynamics Research
  • Medical Imaging and Analysis

Lanzhou University
2025

University of Finance and Economics
2024

Zhejiang University of Technology
2021-2022

Qingdao University
2021

Affiliated Hospital of Qingdao University
2021

Huazhong University of Science and Technology
2021

Third Affiliated Hospital of Sun Yat-sen University
2018-2020

Sun Yat-sen University
2018-2020

Fudan University
2020

Beijing University of Chinese Medicine
2019

The aim of this study was to identify and elucidate the vasorelaxant activity echinacoside, a phenylethanoid glycoside isolated from medicinal herb Cistanche tubulosa, its possible underlying mechanism on rat thoracic aortic rings pre-contracted with phenylephrine (PE, 1 µM) KCl (60 mM). Echinacoside (30–300 exhibited an acute relaxation in endothelium-intact concentration-dependent manner, while significantly inhibited endothelium-denuded condition presence endothelial nitric oxide synthase...

10.1055/s-0029-1185745 article EN Planta Medica 2009-05-25

Post-operative cognitive dysfunction (POCD) could cause short-term or long-term disruption lasting weeks months after anesthesia and surgery in elderly. However, no effective treatment of POCD is currently available. Previous studies indicated that the enhancement brain-derived neurotrophic factor (BDNF) expression, elevation cholinergic system, might be to prevent POCD. In this study, we have discovered tacrine(10)-hupyridone (A10E), a novel acetylcholinesterase (AChE) inhibitor derived...

10.3389/fncel.2018.00396 article EN cc-by Frontiers in Cellular Neuroscience 2018-11-07

After intragastric administration of DOFP for 3 weeks, the rat UC model was made by 4% oral DSS solution one week, and drug given at same time. During experiment, disease activity index (DAI) score rats regularly computed. At end blood routine indexes were obtained. The histopathological changes in colon monitored hematoxylin-eosin (H&E) PAS staining observation ultrastructural transmission electron microscope. Occludin expression Western blot, claudin-1 ZO-1 detected immunofluorescence,...

10.1155/2021/9658638 article EN Evidence-based Complementary and Alternative Medicine 2021-12-30

Pharmacokinetic interactions between casopitant (a substrate and weak to moderate inhibitor of CYP3A), dexamethasone inducer ondansetron mixed CYP substrate) were evaluated in a two-part, three-period, single-sequence study two groups healthy subjects. Part 1: subjects received oral (regimen A); IV B); casopitant, reduced dose dexamethasone, C). 2: D); E); F). Each regimen was separated by 14 days. Casopitant AUC C increased 28% on day 1 but decreased 34% 3 compared alone A. When given with...

10.1007/s00520-008-0571-5 article EN cc-by-nc Supportive Care in Cancer 2009-02-09

Objective: To evaluate the effects of treatment integrative Chinese and Western medicine (ICWM) on arterial oxygen saturation (SaO2) in patients with severe acute respiratory syndrome (SARS).Methods:The non-randomized, controlled trial was conducted 447 SARS treated synchronously western conventional (WM group,n = 171) alone ICWM (ICWM 276). The changes cases normal level (≥95%) or abnormal (<95%) SaO2 were observed dynamically.Results: In 3rd-14th day therapeutic course, percentage group...

10.1007/bf02836381 article EN other-oa Chinese Journal of Integrative Medicine 2004-06-01

Pathogenesis and clinical characteristics of the Budd-Chiari syndrome (BCS) in Asia are somewhat different from ones observed Western countries. Obstruction inferior vena cava (IVC) or hepatic veins is caused to a greater extent by membranous webs than thrombosis. Impaired fibrinolysis has been found European patients with BCS, but its status Chinese this condition still unknown. To explore BCS country, we measured euglobulin lysis time (ELT) for overall plasma levels five fibrinolytic...

10.1097/mbc.0000000000000143 article EN Blood Coagulation & Fibrinolysis 2014-06-07

Abstract Background : Parents’ postnatal sense of security is very important to the experience, and has a positive effect on parental role adaptation, mental health parents, marital relationship, parent-child relationship. This cross-sectional study was conducted describe status quo Chinese parents’ within one week after delivery, identify their related factors. Methods Participants were recruited through convenience samples methods in three grade-A tertiary hospitals China. The Postnatal...

10.21203/rs.3.rs-523065/v1 preprint EN cc-by Research Square (Research Square) 2021-05-21

Fiscal policy uncertainty refers to unpredictability in government taxation and spending decisions, affecting economic planning, investment, consumer behavior, leading market volatility potential slowdowns. In this research, we intend analyze the impact of uncertain fiscal policies on sustainability China, utilizing empirical data. We aim elucidate how fluctuations expenses, budget uncertainties, tax collection affect sustainability, with mitigating effects explored through financial sector...

10.61707/12ker596 article EN cc-by-nc-nd International Journal of Religion 2024-06-20

Pathological area segmentation in cardiac magnetic resonance (MR) images plays a vital role the clinical diagnosis of cardiovascular diseases. Because irregular shape and small area, pathological has always been challenging task. We propose an anatomy prior based framework, which combines U-net network with attention technique. Leveraging fact that pathology is inclusive, we neighborhood penalty strategy to gauge inclusion relationship between myocardium myocardial infarction no-reflow...

10.48550/arxiv.2011.08769 preprint EN cc-by arXiv (Cornell University) 2020-01-01

Abstract Background: We previously reported that trans-resveratrol (resveratrol) downregulates the expression DNA methyltransferases (DNMTs) 1 and 3b in vitro demethylates tumor suppressor gene RASSF-1a breasts of women who are at increased breast cancer risk. Effects with increasing dose/circulating level agent, respectively. In current report, we evaluated effect doses resveratrol on mammary formation ACI rat, which develops estrogen dependent carcinoma. Methods: 91 female rats were...

10.1158/1940-6207.prev-12-a36 article EN Cancer Prevention Research 2012-11-01
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