A5110926286- Immunotherapy and Immune Responses
- Hematopoietic Stem Cell Transplantation
- Protease and Inhibitor Mechanisms
- Hematological disorders and diagnostics
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- RNA modifications and cancer
- Neuroscience and Neuropharmacology Research
- Virus-based gene therapy research
- Phagocytosis and Immune Regulation
- Multiple Myeloma Research and Treatments
- Liver physiology and pathology
- Muscle Physiology and Disorders
- Effects and risks of endocrine disrupting chemicals
- Tribology and Lubrication Engineering
- Pickering emulsions and particle stabilization
- Acute Myeloid Leukemia Research
- Polymer composites and self-healing
- Thermal Regulation in Medicine
- Mesenchymal stem cell research
- Flavonoids in Medical Research
- Atherosclerosis and Cardiovascular Diseases
- Parathyroid Disorders and Treatments
- Intracranial Aneurysms: Treatment and Complications
Nanjing Medical University
2011-2025
Jiangsu Province Hospital
2025
Stomatology Hospital
2023-2024
Sun Yat-sen University
2023-2024
Shenzhen University
2024
Nanjing University
2023
University of Cambridge
2022
The University of Sydney
2007-2022
Sichuan University
2022
West China Medical Center of Sichuan University
2022
Significance Natural regulatory T cells (nTregs) play important roles in preventing autoimmune diseases, but they may be unstable the presence of inflammation. Here we report that all - trans RA (atRA) not rapamycin prevents human nTregs from converting to Th1/Th17 and sustains their suppressive function inflammatory environments. Adoptive transfer pretreated with atRA enhances effects on xenograft-vs. host diseases. Moreover, show suppresses IL-1 receptor upregulation, accelerates IL-6...
TGF-β and Foxp3 expressions are crucial for the induction functional activity of CD4(+)Foxp3(+) regulatory T (iTreg) cells. Here, we demonstrate that although TGF-β-primed CD8(+) cells display much lower expression, their suppressive capacity is equivalent to CD4(+) iTreg cells, both Foxp3(-) Foxp3(+) CD8+ subsets have activities in vitro vivo. CD8(+)Foxp3(-) produce little IFN-γ but almost no IL-2, a typical anergic phenotype. Among phenotypic markers expressed identify CD103 expression...
Background Tissue inhibitor of metalloproteinases-3 (TIMP-3) inhibits matrix metalloproteinases and membrane-bound sheddases. TIMP-3 is associated with the extracellular expressed in highly remodeling tissues. function hematopoietic system unknown. Methodology/Principal Findings We now report that endosteal region bone marrow (BM), particularly by osteoblasts, endothelial multipotent mesenchymal stromal cells which are all important cellular components stem cell (HSC) niches, whereas its...
Osteoblasts are necessary to B lymphopoiesis and mobilizing doses of G-CSF or cyclophosphamide inhibit osteoblasts, whereas AMD3100/Plerixafor does not. However, the effect these agents on has not been reported. Mice (wild-type, knocked-out for TNF-α TRAIL, over-expressing Bcl-2) were mobilized with G-CSF, cyclophosphamide, AMD3100. Bone marrow, blood, spleen lymph node content in cells was measured. stopped medullar concomitant loss B-cell colony-forming units, pre-pro-B, pro-B, pre-B...
ABSTRACT It is known that ATRA promotes the development of TGF-β-induced CD4+Foxp3+ iTregs, which play a vital role in prevention autoimmune diseases; however, facilitating differentiation and function CD8+Foxp3+ iTregs remains elusive. Using head-to-head comparison, we found promoted expression Foxp3 CD4+ but it did not promote on CD8+ cells. standard vitro assay, demonstrated induced by TGF-β were superior to alone. In cGVHD, typical lupus syndrome model where DBA2 spleen cells transferred...
Age-related macular degeneration (AMD) as a disease entity is "dry" at early stage and made up of two main components late stage: atrophic AMD exudative AMD. Quercetin acts an anti-oxidant to protect retinal pigment epithelial cells (RPE) from damaged by oxidative stress, but its effect on formation choroidal neovascularization (CNV) in unclear. The aim this study investigate the quercetin CNV AMD.The development induced laser was detected fluorescein angiography (FA). Colored microsphere...
Objective. To study the effect of Hanchuan Zupa granule combined with conventional western medicine in treatment children bronchial asthma. Methods. 98 cases Fengrun District People’s Hospital Tangshan City from June 2018 to February 2021 were selected. The control group was given oxygen therapy, antibiotics, and aerosol inhalation quick acting β 2 receptor agonist, glucocorticoid, other treatment, while observation treated Bairui on basis group. course two groups 1 week. Results. After...
Tumour invading muscle in head and neck squamous cell carcinoma (HNSCC) is often associated with destructive growth poor prognosis. However, the phenotypic functions pathological mechanisms of muscle-invasive cancer cells tumour progress remains unknown. In this study, we aimed to investigate HNSCC their potential crosstalk microenvironment. We obtained scRNA-seq data (SC) from GSE103322 (N = 18) GSE181919 37), spatial RNA-seq (ST) GSE208253 GSE181300 4), transcriptomics human samples...
ABSTRACT Harmonic gears are widely used in precise space technology, robotic, medical equipment and other fields, while the magnitude of surface topography changes due to wear is usually comparable or larger than original roughness elastic deformation, leading severe transmission failures. This paper reports a numerical approach simulate lubrication status considering evolution based on mixed elastohydrodynamic (EHL) Archard models, which Reynolds equation solved with finite difference...
To investigate the effect of flavone on ocular blood flow in rabbit eyes and formation choroidal neovascularization (CNV) rat model age-related macular degeneration (AMD).In vivo studies, colored microsphere technique was used to determine hypertensive eyes. The were treated with 0.5% eye drops 3 times a day for 1 week before 4 weeks after laser-induced injury Bruch's membrane. development CNV determined by fluorescein angiography (FA) performed 2nd 4th injury. In vitro viability human...
Endothelial dysfunction is a major feature of vascular diseases. A practical, minimally invasive method to effectively “probe” gene transcription for an individual patient's endothelium has potential “customize” assessment at risk disease as well pathophysiologic insight in vivo human, clinical context. Published literature lacks methodology identify endothelial differential expression individuals with disease. We describe do so. The aim this study was specifically utilize (a) cutaneous...
Background: In individuals afflicted with lung adenocarcinoma, the principal cause of mortality is frequently attributed to distant metastasis, brain representing preeminent location for such metastatic events. Despite this established clinical correlation, there exists a conspicuous lack clarity concerning molecular underpinnings, pivotal regulatory genes, and biomarkers associated metastasis from adenocarcinoma.Methods: Initially, we embarked on exploration assessment quantitative...
Objective To evaluate the therapeutic efficacy of sutured intraocular lens placement in aphakic post-vitrectomy eyes via 3mm incision surgery and 25 G irrigation. Methods Twenty-nine patients (29 eyes) were eyes, including 22 males 7 females. Before operation, uncorrected distance visual acuity was from counting fingers to 0.08, best corrected 0.3 1.0 with +8.50 ～ +13.50 DS -0.75～-2.50 DC. All cases performed which a Akreos foldable IOL used facilitate 2-point fixation through irrigating....