A5101522507- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Metabolism, Diabetes, and Cancer
- Systemic Lupus Erythematosus Research
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Inflammasome and immune disorders
- Pancreatic function and diabetes
- Immune Response and Inflammation
Sun Yat-sen University
2013-2024
Sun Yat-sen Memorial Hospital
2013-2024
Third Affiliated Hospital of Sun Yat-sen University
2016
Abstract Foxp3+ regulatory T cells (Treg) playing a crucial role in the maintenance of immune tolerance and prevention autoimmune diseases consist thymus-derived naturally occurring CD4+Foxp3+ Treg (nTreg) those that can be induced ex vivo with TGF-β (iTreg). Although both subsets share similar phenotypes functional characteristics, they also have potential biologic differences on their biology. The iTreg regulating B remains unclear so far. suppression assays activation, proliferation, Abs...
TGF-β and Foxp3 expressions are crucial for the induction functional activity of CD4(+)Foxp3(+) regulatory T (iTreg) cells. Here, we demonstrate that although TGF-β-primed CD8(+) cells display much lower expression, their suppressive capacity is equivalent to CD4(+) iTreg cells, both Foxp3(-) Foxp3(+) CD8+ subsets have activities in vitro vivo. CD8(+)Foxp3(-) produce little IFN-γ but almost no IL-2, a typical anergic phenotype. Among phenotypic markers expressed identify CD103 expression...
Lupus nephritis is one of most severe complications systemic erythematosus lupus (SLE) and current approaches are not curative for nephritis. Although CD4+Foxp3+ regulatory T cells crucial prevention autoimmunity, the therapeutic effect these on satisfactory. We previously reported that CD8+CD103+ induced ex vivo with TGF-β1 IL-2 (CD8+CD103+ iTreg), regardless Foxp3 expression, displayed potent immunosuppressive Th cell response had cell-mediated colitis. Here, we tested whether iTreg can...
CD4+Foxp3+ regulatory T (Treg) cells are crucial for maintaining homeostasis and preventing autoimmune diseases. Nonetheless, we others have previously reported that natural Treg unstable dysfunctional in the inflamed environment with a high-salt diet, limiting function disease control. In this study, made an innovative observation showing high degree of heterogeneity within pool. We identified CD126, interleukin (IL)-6 receptor alpha chain, contributed to cell instability. Using series...