A5100359101- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Bone Metabolism and Diseases
- RNA Research and Splicing
- Diabetes and associated disorders
- Immunodeficiency and Autoimmune Disorders
- Rheumatoid Arthritis Research and Therapies
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- Psoriasis: Treatment and Pathogenesis
- Reproductive System and Pregnancy
- Circular RNAs in diseases
- Viral Infections and Immunology Research
- Inflammatory mediators and NSAID effects
- Lung Cancer Treatments and Mutations
- Angiogenesis and VEGF in Cancer
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Biomedical Research and Pathophysiology
- Phagocytosis and Immune Regulation
- Bipolar Disorder and Treatment
- Ovarian function and disorders
- Antimicrobial Peptides and Activities
First Affiliated Hospital of Nanchang University
2024
Nanchang University
2024
Third Affiliated Hospital of Sun Yat-sen University
2019-2023
Sun Yat-sen University
2019-2023
Guangzhou University of Chinese Medicine
2023
Songjiang District Central Hospital
2023
Shanghai Institute of Pharmaceutical Industry
2023
Sun Yat-sen Memorial Hospital
2022
The Ohio State University Wexner Medical Center
2019-2021
Hebei University of Engineering
2021
H-Y is a transplantation antigen that can lead to rejection of male organ and bone marrow grafts by female recipients, even if the donor recipient match at major histocompatibility locus humans, HLA (human leukocyte antigen) locus. However, origin function antigens has eluded researchers for 40 years. One human presented HLA-B7 was identified as an 11-residue peptide derived from SMCY, evolutionarily conserved protein encoded on Y chromosome. The homologous gene X chromosome, SMCX, differs...
A paradigm shift in immunology has been the recent discovery of regulatory T cells (T reg cells), which CD4+Foxp3+ are proven as essential to self-tolerance. Using transgenic B6.Foxp3hCD2 mice isolate and ablate Foxp3+ with an anti-hCD2 antibody, we show for first time that crucial infectious tolerance induced by nonablative anti–T cell antibodies. In tolerant animals, constantly required suppress effector still capable causing tissue damage. Tolerated contains rejecting it, but prevented...
Abstract Tumor Necrosis Factor (TNF) α is a multifunctional cytokine with pro-inflammatory and anti-inflammatory characteristics. Increasing evidence suggests that thymus-derived, natural regulatory T cells (nTreg) express remarkably high level of TNF Receptor 2 (TNFR2) TNFα modulates the number or function nTreg via TNFR2 in autoimmune diseases. Nonetheless, Treg consist at least iTreg are induced periphery vitro two subsets may have different biological However, role TNF-TNFR signaling...
Osteoporosis is a disease in which the density and quality of bone are reduced, causing bones to become weak so brittle that fall or even mild stresses can cause fracture. Current drug treatment consists mainly antiresorptive agents unable stimulate new formation. Our recent studies have defined critical role gingiva-derived mesenchymal stem cells (GMSCs) attenuating autoimmune arthritis through inhibition osteoclast formation activities, but it remains be ruled out whether administration...
Rheumatoid arthritis (RA) is a systemic autoimmune disease with limited treatment success, characterized by chronic inflammation and progressive cartilage bone destruction. Accumulating evidence has shown that neutrophil extracellular traps (NETs) released activated neutrophils are important for initiating perpetuating synovial thereby could be promising therapeutic target RA. K/B × N serum transfer-induced (STIA) rapidly developed joint inflammatory model somehow mimics the response in...
CD4(+)Foxp3(+) regulatory T cells (Treg) are essential for immune homeostasis and maintenance of self-tolerance. They produced in the thymus also generated de novo periphery a TGF-β-dependent manner. Foxp3(+) Treg required to achieve tolerance transplanted tissues when induced by coreceptor or costimulation blockade. Using TCR-transgenic mice avoid issues autoimmune pathology, we show that Foxp3 expression is both necessary sufficient tissue Moreover, known need induction TGF-β signaling can...
IL-2 inducible T cell kinase (ITK) is critical in helper subset differentiation and its inhibition has been suggested for the treatment of cell-mediated inflammatory diseases. follicular (Tfh), Th17 regulatory cells (Treg) also play important roles development rheumatoid arthritis (RA), while role ITK RA intricate balance between effector remains unclear. Here, we found that CD4+ from patients presented with an elevated activation. inhibitor alleviated existing collagen-induced (CIA) reduced...
Abstract To explore altered patterns of static and dynamic functional brain network connectivity (sFNC dFNC) in Primary angle-closure glaucoma (PACG) patients. Clinically confirmed 34 PACG patients 33 age- gender-matched healthy controls (HCs) underwent evaluation using T1 anatomical MRI on a 3 T scanner. Independent component analysis, sliding window, the K-means clustering method were employed to investigate (FNC) temporal metrics based eight resting-state networks. Differences FNC...
Oleanolic acid (OA) is a triterpenoid commonly found in plants and has shown extensive pharmaceutical activities. This study aimed to investigate the underlying mechanism of antiosteoporosis (OP) action OA by utilizing network pharmacology approach molecular docking methods. First, targets were identified using GeneCards, Stitch, Swisstarget databases, related OP mined NCBI, Genecards, DisGeNet databases. The overlapped regarded as candidate targets, String database was used obtain...
Regulatory T cells expressing the transcription factor Foxp3 require acquisition of a specific hypomethylation pattern to ensure optimal functional commitment, limited lineage plasticity and long-term maintenance tolerance. A better understanding molecular mechanisms involved in generation these epigenetic changes vivo will contribute clinical exploitation Foxp3+Treg. Here we show that both vitro generated antigen Foxp3+Treg can acquire Treg-specific characteristics prevent skin graft...
Background A proinflammatory milieu emerging in the lung due to neutrophil accumulation and activation is a key pathogenesis of acute injury (ALI). 15-deoxy-Δ 12,14 -prostaglandin J 2 (15d-PGJ ), one terminal products cyclooxygenase-2 pathway, known be endogenous ligand peroxisome proliferator-activated receptor γ (PPAR-γ) with multiple physiological properties. Growing evidence indicates that 15d-PGJ has anti-inflammatory, anti-proliferative, cytoprotective pro-resolving effects. We...
CD4+Foxp3+ regulatory T (Treg) cells are crucial for maintaining homeostasis and preventing autoimmune diseases. Nonetheless, we others have previously reported that natural Treg unstable dysfunctional in the inflamed environment with a high-salt diet, limiting function disease control. In this study, made an innovative observation showing high degree of heterogeneity within pool. We identified CD126, interleukin (IL)-6 receptor alpha chain, contributed to cell instability. Using series...
Fructus Ligustri Lucidi (FLL) is the fruit of Ligustrum lucidum Ait and a component many kidney-tonifying traditional Chinese medicine formulae for treating osteoporosis. Accumulating evidence has linked oxidative stress with progression bone diseases. The present study aimed to identify effects FLL on stress-related osteoporosis in vivo vitro. To construct animal models, we utilized d-galactose (D-gal) injection induce combined low calcium (the exact percentage diet was 0.1%) diet....
Human osteosarcoma is the most frequent primary malignant of bone, and often occurs in adolescents. However, molecular mechanism this disease remains unclear. In present study, we found that level Rhotekin 2 (RTKN2) was up-regulated tissues cell lines. addition, silencing RTKN2 human lines U2OS, inhibited proliferation, induced G1 phase cycle arrest via reducing cyclin-dependent kinase (CDK2). Furthermore, knockdown U2OS cells apoptosis by increasing Bax decreasing Bcl2. These results...
CD4+Foxp3+ regulatory T cells (Tregs) play a crucial role in preventing autoimmunity and inflammation. There are naturally-derived the thymus (tTreg), generated extrathymically periphery (pTreg), induced vitro culture (iTreg) with different characteristics of suppressiveness, stability, plasticity. is an abundance published data on neuropilin-1 (Nrp-1) as tTreg marker, but little exist iTreg. The fidelity Nrp-1 marker its iTreg remains to be explored. This study found that was expressed by...
In this paper, we use the gray model through consolidation of original data to find changing laws system, generate a strong regularity series, thus well predict trend future. Meanwhile, considered defect that grey action traditional GM(1,1) is constant, introduce sine function relation and make into dynamic variable which contains time function. Thus, optimized. Finally, result shows optimized can simulate better, has higher accuracy.