A5100615377- Magnesium Alloys: Properties and Applications
- Aluminum Alloys Composites Properties
- Corrosion Behavior and Inhibition
- T-cell and B-cell Immunology
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Bone Tissue Engineering Materials
- Cancer Mechanisms and Therapy
- Advancements in Battery Materials
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Systemic Lupus Erythematosus Research
- interferon and immune responses
- Mesenchymal stem cell research
- Immune cells in cancer
- Periodontal Regeneration and Treatments
- Advanced Glycation End Products research
- Hydrogen Storage and Materials
- Asthma and respiratory diseases
- Advanced Battery Materials and Technologies
- Peripheral Artery Disease Management
- Autophagy in Disease and Therapy
- Liver Disease and Transplantation
- Macrophage Migration Inhibitory Factor
- Immunotherapy and Immune Responses
Third Affiliated Hospital of Sun Yat-sen University
2018-2025
Sun Yat-sen University
2018-2025
Qingdao National Laboratory for Marine Science and Technology
2021-2024
Marine Biomedical Research Institute of Qingdao
2024
Songjiang District Central Hospital
2024
Hubei University of Medicine
2024
University of Chinese Academy of Sciences
2023
Shandong Institute of Automation
2023
Chinese Academy of Sciences
2011-2023
Sun Yat-sen Memorial Hospital
2023
Hepatocellular carcinoma ( HCC ) is a malignancy with one of the worst prognoses. Long noncoding RNA (lnc are emerging as an important regulator gene expression and function, leading to development cancer. The aim this study was determine relationship between lnc further guide clinical therapy. in adjacent tissues were screened, correlation ‐ PDPK 2P liver pathological characteristics severity assessed. effects on proliferation, apoptosis, metastasis, invasion also systematically...
Lupus nephritis is one of most severe complications systemic erythematosus lupus (SLE) and current approaches are not curative for nephritis. Although CD4+Foxp3+ regulatory T cells crucial prevention autoimmunity, the therapeutic effect these on satisfactory. We previously reported that CD8+CD103+ induced ex vivo with TGF-β1 IL-2 (CD8+CD103+ iTreg), regardless Foxp3 expression, displayed potent immunosuppressive Th cell response had cell-mediated colitis. Here, we tested whether iTreg can...
Chronic rhinosinusitis (CRS) is a common chronic inflammatory disease of the upper airways involving nasal cavity and sinus. Deriving both from its clinical complexity with protean manifestations as well pathogenetic heterogeneity, molecular mechanisms contributing to pathogenesis CRS remain unclear, attract wide interest in field. Current evidences indicate that IL-17A highly expressed polyps (CRSwNP). However, role regulation tissue remodeling CRSwNP remains unknown. The present study...
Gut microbiota dysbiosis and intestinal barrier injury play vital roles in Alzheimer's disease (AD) onset development. Our previous studies have demonstrated that manual acupuncture (MA) could improve the cognitive abilities of APP/PS1 mice. However, effect MA on mucosal gut mechanism through which this occurs remain to be clarified.
Abstract Introduction and Aims Alzheimer's disease (AD) is characterized by the abnormal accumulation of hyperphosphorylated tau proteins amyloid‐beta (Aβ) peptides. Recent studies have shown that many microRNAs (miRNAs) are dysregulated in AD, modulation these miRNAs can influence development Aβ pathology. The brain‐specific miRNA miR‐128, encoded MIR128‐1 MIR128‐2 , important for brain AD. In this study, role miR‐128 pathology as well regulatory mechanism underlying its dysregulation were...
Rheumatoid arthritis (RA) is a systemic autoimmune disease with limited treatment success, characterized by chronic inflammation and progressive cartilage bone destruction. Accumulating evidence has shown that neutrophil extracellular traps (NETs) released activated neutrophils are important for initiating perpetuating synovial thereby could be promising therapeutic target RA. K/B × N serum transfer-induced (STIA) rapidly developed joint inflammatory model somehow mimics the response in...
Glioblastoma (GBM) is a highly invasive and challenging primary tumor of the central nervous system (CNS), currently available treatments provide limited benefits to patients with this disease.Therefore, development novel therapeutic targets effective treatment strategies essential.Nimustine hydrochloride (ACNU) widely used as standard chemotherapeutic agent frequently administered together other agents in clinical studies.Curcumin, natural polyphenolic compound, could potentially be...
Aberrant number and/or dysfunction of CD4+Foxp3+ Regulatory T cells (Tregs) are associated with the pathogenesis rheumatoid arthritis (RA). A previous study has demonstrated that thymus-derived, natural Tregs (nTregs) prefer to accumulate in inflamed joints and transdifferentiate TH17 under stimulation synovial fibroblasts (SFs). In this study, we made a head-to-head comparison both Treg subsets induced (iTregs), but not nTregs, retained Foxp3 expression regulatory function on effector...
Cellular senescence (CS) is recognized as a critical driver of aging and age-related disorders. Recent studies have emphasized the roles ion channels key mediators CS. Nonetheless, regulatory mechanisms chloride intracellular (CLICs) during CS remain largely unexplored. In this study, we conducted RNA sequencing on bleomycin-induced senescent lung tissues from mice identified Clic3 most significantly upregulated CLIC member. Furthermore, our findings revealed that knockdown CLIC3 mitigated...
Clinical reports have highlighted a role for retinoids in the etiology of mood disorders. Although we had shown that recruitment nuclear receptor retinoic acid receptor-α (RAR-α) to corticotropin-releasing hormone (CRH) promoter is implicated activation hypothalamus–pituitary–adrenal (HPA) axis, further insight into how modulate HPA axis activity lacking. Here show all-trans (RA)-induced involves impairments glucocorticoid (GR) negative feedback. RA was applied rats chronically through...
Mounting evidence has shown that a novel subset of mesenchymal stem cells (MSCs) derived from human gingiva referred to as gingival (GMSCs) displays greater immunotherapeutic potential and regenerative repair expression than MSCs obtained other tissues. However, the safety use transplanted GMSCs in humans remains unclear. In this study, we evaluated into mouse, rat, rabbit, beagle dog, monkey well two animal models autoimmune diseases. short- long-term toxicity tests, infused had no...
Phosphor doping creates well-defined Brønsted acid and base sites on h-BN nanosheets, ensuring the smooth proceeding of deacetalization–Knoevenagel cascade reaction.
Objective Although the potential involvements of INK4 locus reported in glaucoma, effects long non-coding RNA (lncRNA) antisense noncoding (ANRIL) on trabecular meshwork (TM) cells remain unclear. In this study, we aimed to explore lncRNA ANRIL oxidative injury human TM as well underlying mechanisms. Materials and methods Oxidative was induced by H2O2 stimulation. Cell viability, apoptotic cells, expression proteins related apoptosis, reactive oxygen species (ROS) level were testified CCK-8...