Lupus nephritis is one of most severe complications systemic erythematosus lupus (SLE) and current approaches are not curative for nephritis. Although CD4+Foxp3+ regulatory T cells crucial prevention autoimmunity, the therapeutic effect these on satisfactory. We previously reported that CD8+CD103+ induced ex vivo with TGF-β1 IL-2 (CD8+CD103+ iTreg), regardless Foxp3 expression, displayed potent immunosuppressive Th cell response had cell-mediated colitis. Here, we tested whether iTreg can...

The incidence of human brucellosis has risen sharply in China but little is known about trends pastoral and agricultural areas respectively. This study aimed to analyze the annual monthly from 2004 2019. It sought identify factors contributing higher rates at specific times compare across pastoral, agricultural/pastoral, areas. Annual numbers reported cases regional between 2019 were accessed National Public Health Science Data Sharing Center, percentage change (APC) was calculated. analyzed...

Despite the considerable efforts made to address issue of brucellosis worldwide, its prevalence in dairy products continues be difficult estimate and represents a significant public health concern globally. The aim present study was gain better understanding epidemiology this disease mainland China. We set out investigate annual spatial distribution potential hotspots disease. Data on incidence rate from 2012 2018 obtained China Disease Control Prevention Information System (CDCIS). ArcGIS...

Abstract Background Brucellosis is a major public health issue in China, while its temporal and spatial distribution have not been studied depth. This study aims to better understand the epidemiology of brucellosis mainland by investigating human, clustering characteristics disease. Methods Human data from China between 2012 2016 were obtained Information System for Disease Control Prevention. The autocorrelation analysis ArcGIS10.6 spatial-temporal scanning SaTScan software used identify...

Objective To test psychometrics of the Short Form 36 Health Survey version 2 (SF-36v2) and Quality Life Scale for Drug Addicts (QOL-DAv2.0) in Chinese mainland patients with methadone maintenance treatment (MMT). Methods A total 1,212 were recruited from two MMT clinics Xi'an, China. Reliability was estimated Cronbach's α intra-class correlation (ICC). Convergent discriminant validity assessed using multitrait-multimethod matrix. Sensitivity measured ANOVA relative efficiency. Responsiveness...

Neurofibromatosis type 1 (NF1) is a genetic disorder associated with neurofibromin gene mutation, which generates an increased risk of variety tumor types. The current study reports case involving NF1, pheochromocytoma (PHEO) and gastrointestinal stromal tumors (GIST). A 56-year-old man presented abdominal pain polypnea. Clinical investigation revealed multiple diffuse soft-tissue lesions throughout his body, pigmented macules on the skin. Imaging analyses thoracic scoliosis, subcutaneous...

Despite the considerable efforts made to address issue of brucellosis worldwide, its prevalence in dairy products continues be difficult estimate and represents a key public health around world today. The aim present study was better understand epidemiology this disease mainland China. We set out investigate yearly spatial distribution possible hotspots disease.Human data from China between 2007 2016 were collected Information System for Disease Control Prevention. A geographic information...

Social support has been considered one of the most important factors health-related quality life (HRQoL) evaluations among different populations; however, few studies have explored relationships both received and perceived social to HRQoL patients undergoing methadone maintenance treatment (MMT). Thus, purpose this cross-sectional study was clarify these relationships. Participants were admitted at two largest privately publicly funded MMT clinics in Xi'an. The main explanatory variable...

The potential impact of increasing test-and-treat coverage on hepatitis B virus (HBV) infection remains unclear in China. objective this study was to develop a dynamic compartmental model at population level estimate the long-term effect strategy. Based natural history HBV and 3 serosurvey data China, we proposed an age- time-dependent discrete predict number new infection, chronic HBV-related deaths for time from 2018 2050 under 5 different compared them with current intervention policy....

It is useful to advance simulated patient (SP) participation in teaching improve the communication skills of medical students, so this study aims explore current state Chinese mainland SP education.A cross sectional survey was designed utilizing well defined quantitative research methods and descriptive statistics. The questionnaire sought information which elucidated status SP-based education, origin learning, training, challenges learning strategy future developments. Questionnaires were...

The age-specific seroclearance pattern of hepatitis B surface antigen (HBsAg) in chronic virus (HBV) infections China remains unclear. In this study, based on three national serosurvey data China, we propose an age- and time-dependent discrete model use the method non-linear least squares to estimate annual rate HBsAg seroclearance. We found that HBV aged 1-59 years occurred at average 1.80% (95% CI, 1.54-2.06%) from 1993 2006. predominantly early childhood, 20-24 35-39 year age groups....

ABSTRACT Objective This study was designed to examine the correlation between serum uric acid (SUA) and fasting plasma glucose (FPG) levels across non‐diabetic, pre‐diabetic, diabetic adults from Northwest China. Materials Methods utilized data a cross‐sectional survey conducted in Ningxia Hui Autonomous Region, which investigated prevalence risk factors of cardiovascular disease. All subjects underwent tests for SUA FPG levels. Generalized additive models two‐piecewise linear regression...

Importance Length of hospital stay (LOHS) is the main cost-determining factor hospitalization for stroke patients. However, previous analyses involving LOHS did not consider confounding or indirect factors, effects other factors on and inpatient costs. Objective To investigate direct costs inpatients with ischemic hemorrhagic stroke. Design, setting, participants This was a population-based, retrospective, observational study that analyzed data acquired from Nationwide Inpatient Sample...

This study aimed to explore the bidirectional relationships between retention and health-related quality of life (HRQoL) in patients from mainland China receiving methadone maintenance treatment (MMT). prospective cohort recruited 1,212 eligible MMT two largest clinics (one privately another publicly funded) Xi'an. started March 2012 with a 2-year follow-up until 2014. Retention was assessed by repeated terminations, past duration, premature duration. HRQoL evaluated using Chinese (simple)...

The relationship between dementia and the mortality of stroke is a significant concern for patients careers. However, there are few research about it in China lack reliable data on risk dementia. We aim to analyze compare death with without Further investigation into predictive value death.All who were identified among residents Ningxia, January 1, 2014 December 31, 2021, set or May 22, 2022 as observation endpoint. All screened by 1:4 propensity score matching (PSM). association all-cause...

To investigate changes in the incidence of infections by extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) and analyzed whether there was an association between endogenous organism due to COVID-19 infection ESBL-E.The study a single-center retrospective case-control design. A total 107 patients infected ESBL-E during pandemic were selected as case group, while 214 uninfected 1:2 propensity score matching (PSM) acted control group. Univariate analysis, LASSO logistic...

This study aimed to evaluate whether tenofovir prophylaxis for mothers with high viral loads in late pregnancy is a cost-effective way prevent mother-to-child hepatitis B virus (HBV) transmission China.A decision tree Markov model was constructed cohort of infants born HBV surface antigen-positive China, 2016. The expected cost and effectiveness were compared between the current active-passive immunoprophylaxis strategy strategy, incremental cost-effectiveness ratio calculated. One-way...

Vitamin D status and risk factors of deficiency in chronic kidney disease (CKD) patients China have been seldom reported before. In this study, we aim to investigate serum 25-hydroxyvitamin [25(OH)D] find the predictors predialysis with Stage 3-5 CKDs Southern China.In retrospective cross-sectional hospitalized who were diagnosed CKD had taken measurement 25(OH)D a single center from January 2014 June 2015 included. Patients divided into group nondeficiency depending on cutoff value 37...

Objective: To analyze the spatial-temporal distribution characteristics of human brucellosis (HB) in Ningxia Hui Autonomous Region (Ningxia) from 2012 to 2018 and correlation between HB number livestock stocks, so as provide reference for development preventive measures. Methods: Data on incidence was collected Infectious Disease Report Information Management System Ningxia, 2018. related then analyzed by global spatial autocorrelation local analysis methods through geographic information...

<title>Abstract</title> <bold>Background: </bold>Talaromycosis(TSM) commonly occurs in immunodeficient or immunosuppressed individuals, but it can also occur healthy populations. The present case reports the COVID-19 together with human immunodeficiency virus(HIV) and TSM. <bold>Case Presentation:</bold> This report describes a 26-year-old male who presented fever cough for 20 days. He was diagnosed viral pneumonia through real-time RT-PCR assay chest CT scan. However, his symptoms failed to...