A5101887949- Bone Tissue Engineering Materials
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Graphene and Nanomaterials Applications
- Luminescence Properties of Advanced Materials
- Orthopaedic implants and arthroplasty
- Cardiovascular Function and Risk Factors
- Nanoplatforms for cancer theranostics
- Magnesium Alloys: Properties and Applications
- Advanced Fiber Optic Sensors
- Periodontal Regeneration and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Electrospun Nanofibers in Biomedical Applications
- Circular RNAs in diseases
- Extracellular vesicles in disease
- MXene and MAX Phase Materials
- Dental Implant Techniques and Outcomes
- Plasmonic and Surface Plasmon Research
- Analytical Chemistry and Sensors
- Corneal surgery and disorders
- Laser-Ablation Synthesis of Nanoparticles
- COVID-19 diagnosis using AI
- Neuropeptides and Animal Physiology
- Hydrogels: synthesis, properties, applications
- Advanced Nanomaterials in Catalysis
Anhui Medical University
2025
Henan University
2025
Zhengzhou University
2025
Henan Provincial People's Hospital
2025
Liaocheng University
2011-2024
Liaocheng People's Hospital
2015-2024
Shandong First Medical University
2022-2024
North Minzu University
2023
Shandong University
1998-2022
Weatherford College
2021-2022
Present study demonstrates the fiber-optic localized surface plasmon resonance (LSPR) based sensitive biosensor for detection of Shigella bacterial species. The proposed sensor is comprised multi-core fiber (MCF) having seven cores arranged in a hexagonal shape and spliced with single-mode (SMF) efficient detection. An increase evanescent waves (EWs) coupling modes between MCF was achieved by etching process controlled manner. also increases refractive index sensitivity (RIS) sensor....
In this work, a combination of simulation and experiment is used to analyze the distribution evanescent field in W-shaped optical fiber. A novel flexible fiber (FWOF) biosensor based on localized surface plasmon resonance (LSPR) effect (also known as WaveFlex biosensor) designed fabricated for detecting histamine food. First, gold nanoparticles (AuNPs) are immobilized FWOF probe's excite LSPR effect. Second, niobium carbide (Nb <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML"...
The effective healing of a bone defect is dependent on the careful coordination inflammatory and bone-forming cells. In current work, pro-inflammatory M1 anti-inflammatory M2 macrophages were co-cultured with primary murine mesenchymal stem cells (BMSCs), in vitro, to establish cross-talk among polarized BMSCs, as well their effects osteogenesis. Meanwhile, influence osteogenesis BMSCs through paracrine forms such exosomes. We focused whether exosomes promote osteogenic differentiation....
A highly sensitive and selective optical fiber-based enzymatic biosensor has been proposed in the present studyfor detection of uric acid (UA) human serum. The working mechanism sensor depends on surface plasma property localized plasmon resonance technique. For this purpose, a micro-ball fiber probe 350 μm diameter was fabricated using advanced fusionsplicer coated with gold nanoparticles (AuNPs) graphene oxide (GO) order to enhance its sensitivity. UV-Visible spectrophotometer...
Abstract The ascorbic acid (AA) is a biomarker that can be used to detect the symptoms of severe disorders such as scurvy, Parkinson’s, Alzheimer’s, and cardiovascular diseases. In this work, simple effective sensor model developed diagnose presence AA samples. To develop sensor, tapered single-mode optical fiber has been with well-known phenomenon localized surface plasmon resonance (LSPR). For LSPR, region immobilized synthesized gold nanoparticles (AuNPs) zinc oxide (ZnO-NPs) whose...
It is hard to achieve safe, effective, and minimally invasive therapies on myocardial infarction (MI) via conventional treatments. To address this challenge, a vascular endothelial growth factor (VEGF)-loaded near-infrared (NIR)-triggered self-unfolding graphene oxide (GO)-poly(vinyl alcohol) (PVA) microneedle (MN) patch was designed fabricated treat MI through surgery (MIS). The folded MN can be easily placed into the chest cavity small cut (4 mm) quickly recover its original shape with 10...
Shigella, a highly infectious and pathogenic Gram-negative bacterium, is widely prevalent in everyday food items, prompting significant research due to its potential hazards. Addressing the need for Shigella detection, this study introduces WaveFlex biosensor based on localized surface plasmon resonance (LSPR) using fiber optics. The sensor tailored detect specific subspecies of <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Shigella</i> ,...
Background/Aims: Dysregulation of microRNAs is correlated with tumor development. The aim this study to investigate the clinicopathologic and prognostic significance microRNA (miR)-409-3p its suppressor roles in lung adenocarcinoma (LAD). Methods: Quantitative real-time PCR (qRT-PCR) was performed detect miR-409-3p expression LAD tissues corresponding noncancerous tissues. Additionally, correlations factors prognosis patients were statistically analyzed. Next, we investigated whether could...
Abstract Repairing damage in the craniofacial skeleton is challenging. Craniofacial bones require intramembranous ossification to generate tissue-engineered bone grafts via angiogenesis and osteogenesis. Here, we designed a mineralized collagen delivery system for BMP-2 vascular endothelial growth factor (VEGF) implantation into animal models of mandibular defects. BMP-2/VEGF were mixed with which was implanted rabbit mandibular. Animals divided (i) controls no factors; (ii) alone; or (iii)...
Biomaterials regulate macrophages and promote regeneration function, which is a new hot pot in tissue engineering regenerative medicine. The research based on macrophage materials biology has appeared happy future, but related regulating promoting still its infancy. surface roughness of biomaterials one the important factors affecting behavior. Previous study also found that many polarization, not including mineralized collagen (MC). In this study, we designed fabricated MC with different...
The design of a novel interpenetrating network hydrogel inspired by the microscopic architecture natural cartilage based on supramolecular sodium alginate (SA) nanofibril is reported in this paper. mechanical strength and toughness poly(vinyl alcohol) (PVA) were significantly improved after being incorporated with network. multiple hydrogen bonds between PVA chains fibers provided an efficient energy dissipation, thus leading to significant increase PVA/SA/NaCl hydrogel. demonstrated...
Abstract In the bone immune microenvironment, cells can regulate osteoblasts through a complex communication network. Macrophages play central role in mediating osteogenesis, exosomes derived from them have osteogenic regulation and be used as carriers tissue engineering. However, there are problems with exosomal therapy alone, such poor targeting, content of loaded molecules cannot reach therapeutic concentration. this study, macrophage-derived modified miR-365-2-5p were developed to...
Most of the existing hydrogel dressings have inadequacies in mechanical performance, biological activities, compatibility, or versatility, which results development rapid, green, and cost-effective approaches for hydrogels biochemical biomedical applications becoming a top-priority task. Herein, inspired by inherent bioactivity, water retention properties, biocompatibility natural polysaccharide hydrogels, we prepared self-healing gels. Using Bletilla striata (BSP), carboxymethyl chitosan...
Background Posttranslational modifications of histone lysine (K) have integral connections with cell metabolism, and participate in the carcinogenesis various cancers. This study focuses on evaluating expression H4 lys 5 lactylation (H4K5lac) its clinical role breast cancer (BC). Methods During this research, immunohistochemistry (IHC) immunoblotting, utilizing a specific primary anti-L-lactyl-histone (Lys 5) rabbit monoclonal antibody, were employed to assess H4K5lac BC tissue chips....
Abstract Photothermal therapy (PTT) has emerged as a promising cancer therapeutic method. In this study, Arg-Gly-Asp (RGD) peptide-conjugated polydopamine-coated gold nanostars (Au@PDA-RGD NPs) were prepared for targeting PTT of hepatocellular carcinoma (HCC). A polydopamine (PDA) shell was coated on the surface by oxidative self-polymerization dopamine (termed Au@PDA NPs). NPs further functionalized with polyethylene glycol and RGD peptide to improve biocompatibility well selectivity toward...
Engineering scaffolds with a structure mimicking that of native cornea allows for addressing the severe donor shortage corneal blindness treatment, which, however, remains challenging. In light stromal (CS) cells can play key role in stroma formation, this study we incorporated CS into three-dimensional (3D) printed from hyaluronic acid-modified gelatin-methacrylate (GelMA-HA) and characterized terms remodeled extracellular matrix (ECM) vitro. Our results illustrated modification GelMA by HA...
Abstract Immune response is an important factor in determining the fate of bone replacement materials, which macrophages play role. It a new idea to design biomaterials with immunomodulatory function reduce inflammation and promote integration by regulating polarization. In this work, properties CaP Zn-Mn-Li alloys specific mechanism action were investigated. We found that Zn0.8Mn0.1Li alloy promoted polarization toward M2 reduced inflammation, could effectively upregulate...
In nature, cellular molecule sensing is usually achieved at the environment/membrane interface. meantime, rapid growth of nanotechnology increasingly pushing engineered nanomaterials to interact with biological surfaces. Herein, inspired by trans-membrane signal transduction, a nano–bio interface has been constructed in this work for biosensing application. The formed between selective biomembrane mimetic surface (SBMMS) and function-oriented 2D nanohybrid. Based on design, target...