A5000922152- Stress Responses and Cortisol
- Anesthesia and Neurotoxicity Research
- Neuroendocrine regulation and behavior
- Birth, Development, and Health
- Protein Structure and Dynamics
- Mass Spectrometry Techniques and Applications
- Receptor Mechanisms and Signaling
- Maternal Mental Health During Pregnancy and Postpartum
- Computational Drug Discovery Methods
- Tryptophan and brain disorders
- Enzyme Structure and Function
- Infant Development and Preterm Care
- Cellular transport and secretion
- Molecular Sensors and Ion Detection
- Biochemical and Molecular Research
- Medicinal Plant Pharmacodynamics Research
- Analytical Chemistry and Chromatography
- Synthesis and characterization of novel inorganic/organometallic compounds
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Chromatography in Natural Products
- Supramolecular Chemistry and Complexes
- SARS-CoV-2 and COVID-19 Research
University of Science and Technology of China
2008-2025
Center for Life Sciences
2024
Northwest University
2006-2024
Hefei National Center for Physical Sciences at Nanoscale
2005-2024
Ministry of Natural Resources
2024
Ministry of Education of the People's Republic of China
2017-2022
Science North
2017
GTx (United States)
2017
Chinese Academy of Sciences
2005-2016
Hefei Institutes of Physical Science
2016
The synthesis and structural characterization of the first homologous, molecular M-M bonded series for group 12 metals are reported. compounds Ar'MMAr' (M = Zn, Cd, or Hg; Ar' C(6)H(3)-2,6-(C(6)H(3)-2,6-Pr(i)(2))(2)) were synthesized by reduction corresponding arylmetal halides alkali metal/graphite (Zn Hg) sodium hydride (Cd). These possess almost linear C-M-M-C core structures with two-coordinate metals. observed bonds distances 2.3591(9), 2.6257(5), 2.5738(3) A zinc, cadmium, mercury...
Abstract A substantial number of human epidemiological data, as well experimental studies, suggest that adverse maternal stress during gestation is involved in abnormal behavior, mental, and cognition disorder offspring. To explore the effect prenatal (PS) on hippocampal neurons, this study, we observed dendritic field pyramidal neurons CA3, examined concentration glutamate (Glu), detected expression synaptotagmin‐1 (Syt‐1) N ‐methyl‐ D ‐aspartate receptor 1 (NR1) hippocampus juvenile female...
Docosahexaenoic acid (22:6n-3; DHA) is known to play a critical role in postnatal brain development. However, no study has been performed investigate its preventive effect on prenatal stress-induced behavioral and molecular alterations offspring. In the present study, rats were exposed restraint stress days 14-20 of pregnancy, three times day, 2 hours each time; DHA was given at doses 100 300 mg/kg/day for two weeks.We showed that caused (1) learning memory impairment, (2) BDNF mRNA level...
Abstract Our purpose was to investigate the effects of prenatal stress on neuronal changes in hippocampus and possible involvement oxidative female male rats. Female offspring (1‐month‐old), whose dams were restrained middle or later pregnant stage (MS LS), studied observe number hippocampal neurons expression nitric oxide synthase (nNOS) hippocampus. Both MS LS induced an increase nNOS‐positive hippocampus; however, both caused a significant decrease female, but not offspring. In addition,...
Abstract Background Increasing attention has been paid to the effect of Epimedium on nervous system, particularly anti-depression function. In present study, we applied network pharmacology introduce a testable hypothesis multi-target mechanisms Epicedium against depression. Methods By reconstructing protein–protein interaction and drug–component–target, predicted key protein targets for treatment Then, through molecular docking, main active components candidate were verified. Results...
Summary Carboxysomes are self‐assembled bacterial microcompartments (BMCs) that encapsulate the enzymes RuBisCO and carbonic anhydrase into a proteinaceous shell, enhancing efficiency of photosynthetic carbon fixation. The chaperone CcmS was reported to participate in assembly β‐carboxysomes; however, underlying molecular mechanism remains elusive. We report crystal structure from Synechocystis sp. PCC 6803, revealing monomer α/β fold. Moreover, its complex structures with two types BMC...
On a plane: Addition of PhCCH to Ar'GaGaAr' (Ar' = 2,6-(2,6-iPr(2)C(6)H(3))(2)C(6)H(3)) yielded the 1,4-digallacyclohexadiene [{Ar'GaC(Ph)CH}(2)] (1), which afforded 1,4-digallatabenzene dianion [Ar'GaC(Ph)CH](2)(2-) (2) upon reduction with potassium (see scheme; C gray, Ga green, K blue). Structural parameters, DFT calculations, and (1)H NMR spectroscopy support aromatic character 2.
Abstract Characterization of the dynamic conformational changes in membrane protein signaling complexes by nuclear magnetic resonance (NMR) spectroscopy remains challenging. Here we report site-specific incorporation 4-trimethylsilyl phenylalanine (TMSiPhe) into proteins, through genetic code expansion. Crystallographic analysis revealed structural that reshaped TMSiPhe-specific amino-acyl tRNA synthetase active site to selectively accommodate trimethylsilyl (TMSi) group. The unique up-field...
Maternal prenatal depression is a significant public health issue associated with mental disorders of offspring. This study aimed to determine if maternal depressive symptoms are changes in neonatal behaviors and brain function at the resting state.
Vacuolar protein sorting 29 (Vps29p), which is involved in retrograde trafficking from prevacuolar endosomes to the trans-Golgi network, performs its biological functions by participating formation of a “retromer complex.” In human cells, this complex comprises four conserved proteins: hVps35p, hVps29p, hVps26p, and nexin 1 (SNX1). Here, we report crystal structure hVps29p at 2.1 Å resolution, first three-dimensional retromer subunits. This novel adopts four-layered α-β-β-α sandwich fold....
We deduced that Agkistrodon actus venom serine proteinases I and II, previously isolated from the of A. acutus (Zhu, Z., Gong, P., Teng, M., Niu, L. (2003) Acta Crystallogr. Sect. D Biol. 59, 547-550), are encoded by two almost identical genes, with only single substitution Asp for Asn at residue 62. Amidolytic assays indicated they possess slightly different enzymatic properties. Crystal structures II were determined resolution 2.0 2.1 A identification trisaccharide...
The coronavirus disease pandemic caused by infection with the severe acute respiratory syndrome 2 (SARS-CoV-2) has affected global healthcare system. As low-molecular-weight drugs have high potential to completely match interactions essential SARS-CoV-2 targets, we propose a strategy identify such using fragment-based approach. Herein, ligand- and protein-observed fragment screening approaches, identified niacin hit 1 binding catalytic pocket of main protease (Mpro) SARS-CoV-2, thereby...
Adolescence is a time of continued brain maturation, particularly in limbic and cortical regions, which undoubtedly plays role the physiological emotional changes. Prenatally stressed offspring rats were used to investigate potential antidepressive-like effects imperatorin (IMP) extracted from root radix angelica. After 4 weeks treatment IMP, behavioral tests (sucrose-preference test, forced-swimming open-field test) measured. 5-hydroxytryptamine (5-HT) concentration hippocampus frontal...