A5050235548- Receptor Mechanisms and Signaling
- Mass Spectrometry Techniques and Applications
- Pancreatic function and diabetes
- Neuropeptides and Animal Physiology
- Diabetes Treatment and Management
- Diabetes Management and Research
- Estrogen and related hormone effects
- Diet, Metabolism, and Disease
- Nitric Oxide and Endothelin Effects
- RNA and protein synthesis mechanisms
- Inflammatory mediators and NSAID effects
Shandong University
2021-2023
Second Hospital of Shandong University
2023
Individual free fatty acids (FAs) play important roles in metabolic homeostasis, many through engagement with more than 40G protein-coupled receptors. Searching for receptors to sense beneficial omega-3 FAs of fish oil enabled the identification GPR120, which is involved a spectrum diseases. Here, we report six cryo-electron microscopy structures GPR120 complex FA hormones or TUG891 and Gi Giq trimers. Aromatic residues inside ligand pocket were responsible recognizing different double-bond...
Structures of prostaglandin receptor EP2 revealed its agonists’ selectivity and G protein coupling mechanism.
Long-chain fatty acids (LCFAs) are not only energy sources but also serve as signaling molecules. GPR120, an LCFA receptor, plays key roles in maintaining metabolic homeostasis. However, whether endogenous ligand-GPR120 circuits exist and how such function pancreatic islets unclear. Here, we found that GPR120 activity δ-cells modulated islet functions. At least two unsaturated LCFAs, oleic acid (OA) linoleic (LA), were identified agonists within islets. These LCFAs promoted insulin secretion...
<p>Long-chain fatty acids (LCFAs) not only are energy sources but also serve as signaling molecules. GPR120, an LCFA receptor, plays key roles in maintaining metabolic homeostasis. However, whether endogenous ligand-GPR120 circuits exist and how such function pancreatic islets unclear. Here, we found that GPR120 activity δ cells modulated islet functions. At least two unsaturated LCFAs, oleic acid (OA) linoleic (LA), were identified agonists within islets. These LCFAs promoted insulin...
<p>Long-chain fatty acids (LCFAs) not only are energy sources but also serve as signaling molecules. GPR120, an LCFA receptor, plays key roles in maintaining metabolic homeostasis. However, whether endogenous ligand-GPR120 circuits exist and how such function pancreatic islets unclear. Here, we found that GPR120 activity δ cells modulated islet functions. At least two unsaturated LCFAs, oleic acid (OA) linoleic (LA), were identified agonists within islets. These LCFAs promoted insulin...