A5101674850- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Neuroendocrine regulation and behavior
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Biopolymer Synthesis and Applications
- Estrogen and related hormone effects
- Protein Structure and Dynamics
- Cancer-related Molecular Pathways
- Monoclonal and Polyclonal Antibodies Research
- Connexins and lens biology
- Natural product bioactivities and synthesis
- Machine Learning in Bioinformatics
- Diabetes Management and Research
- 3D Printing in Biomedical Research
- Retinoids in leukemia and cellular processes
- Amino Acid Enzymes and Metabolism
- Sphingolipid Metabolism and Signaling
- Cancer Research and Treatments
- Endoplasmic Reticulum Stress and Disease
- Genetics, Aging, and Longevity in Model Organisms
- Curcumin's Biomedical Applications
- Synthesis and biological activity
- Adenosine and Purinergic Signaling
- Radiopharmaceutical Chemistry and Applications
Shandong University
2018-2025
Peking University
2025
China Medical University
2008-2010
China Medical University Hospital
2010
Luminal fluid reabsorption plays a fundamental role in male fertility. We demonstrated that the ubiquitous GPCR signaling proteins Gq and β-arrestin-1 are essential for because they mediate coupling between an orphan receptor ADGRG2 (GPR64) ion channel CFTR. A reduction protein level or deficiency of ADGRG2, mouse model led to imbalance pH homeostasis efferent ductules due decreased constitutive CFTR currents. Efferent ductule dysfunction was rescued by specific activation another GPCR,...
GPR126 is a member of the adhesion G protein-coupled receptors (aGPCRs) that essential for normal development diverse tissues, and its mutations are implicated in various pathological processes. Here, through screening 34 steroid hormones their derivatives cAMP production, we found progesterone (P4) 17-hydroxyprogesterone (17OHP) could specifically activate trigger downstream Gi signaling by binding to ligand pocket seven-transmembrane domain C-terminal fragment GPR126. A detailed...
Ceramides play a central role in human health and disease, yet their as systemic signaling molecules remain poorly understood. In this work, we identify FPR2 membrane receptor that specifically binds long-chain ceramides (C14-C20). brown beige adipocytes, C16:0 ceramide binding to inhibits thermogenesis via G i -cyclic AMP pathways, an effect is reversed the absence of FPR2. We present three cryo–electron microscopy structures complex with trimers bound C16:0, C18:0 C20:0 ceramides. The...
The adhesion GPCR ADGRG2, also known as GPR64, is a critical regulator of male fertility that maintains ion/pH homeostasis and CFTR coupling. molecular basis ADGRG2 function poorly understood, in part because no endogenous ligands for have been reported, thus limiting the tools available to interrogate activity. It has shown can be activated by peptide, termed p15, derived from its own N-terminal region Stachel sequence. However, low affinity p15 limits utility characterization. In current...
Tissue regeneration, such as pancreatic islet tissue propagation in vitro, could serve a promising strategy for diabetes therapy and personalised drug testing. However, has not been realised yet. Propagation be divided into two steps, vitro expansion repeated passaging. Even the first step of achieved to date. Here, we describe method that enables clusters isolated from pregnant mice or wild-type rats by employing combination specific regeneration factors chemical compounds vitro. The...
Severe reduction in the β-cell number (collectively known as mass) contributes to development of both type 1 and 2 diabetes. Recent pharmacological studies have suggested that increased pancreatic proliferation could be due specific inhibition adenosine kinase (ADK). However, genetic evidence for function ADK under physiological conditions or a pathological context is still lacking. In this study, we crossed mice carrying LoxP-flanked Adk gene with Ins2-Cre acquire β -cell deficiency...