A5100698220- Cytomegalovirus and herpesvirus research
- HIV Research and Treatment
- Gut microbiota and health
- Herpesvirus Infections and Treatments
- Viral-associated cancers and disorders
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- Reproductive System and Pregnancy
- Liver Disease Diagnosis and Treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Oral microbiology and periodontitis research
- Reproductive Biology and Fertility
- interferon and immune responses
- Ovarian function and disorders
- Parasites and Host Interactions
- Cervical Cancer and HPV Research
- Virology and Viral Diseases
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Natural Language Processing Techniques
- Radiomics and Machine Learning in Medical Imaging
- Bacterial biofilms and quorum sensing
- Probiotics and Fermented Foods
- Breast Lesions and Carcinomas
- Listeria monocytogenes in Food Safety
Fujian Agriculture and Forestry University
2025
Sichuan University
2012-2025
West China Hospital of Sichuan University
2012-2024
Institute for Bioprocessing and Analytical Measurement Techniques
2021-2024
Friedrich Schiller University Jena
2021-2024
Zhejiang Cancer Hospital
2005-2024
National Central University
2024
Second Hospital of Shandong University
2021-2024
Central South University
2013-2023
Chinese Academy of Sciences
2023
Background: The threat of drug-resistant Pseudomonas aeruginosa requires great efforts to develop highly effective and safe bactericide. Objective: This study aimed investigate the antibacterial activity mechanism silver nanoparticles (AgNPs) against multidrug-resistant P. . Methods: antimicrobial effect AgNPs on clinical isolates resistant P was assessed by minimal inhibitory concentration (MIC) bactericidal (MBC). In , alterations morphology structure were observed transmission electron...
ABSTRACT The cytidine deaminase APOBEC3G (A3G) exerts a multifaceted antiviral effect against HIV-1 infection. First, A3G was shown to be able terminate HIV infection by deaminating the cytosine residues uracil in minus strand of viral DNA during reverse transcription. Also, number studies have indicated that inhibits transcription non-editing-mediated mechanism. However, mechanism which directly disrupts is not fully understood. In present study, using cell-based coimmunoprecipitation...
The decline of clinically effective antibiotics has made it necessary to develop more antimicrobial agents, especially for refractory biofilm-related infections. Silver nanoparticles (AgNPs) are a new type agent that can eradicate biofilms and reduce bacterial resistance, but its anti-biofilm mechanism not been elucidated. In this study, we investigated the molecular AgNPs against multidrug-resistant Pseudomonas aeruginosa by means tests, scanning electron microscopy (SEM), tandem mass tag...
The coronavirus disease 2019 (COVID-19) pandemic aroused global public concern and became a major medical issue. This study aims to investigate the research routine trends of over last twenty years based on production, hotspots, frontiers published articles as well provide health system with bibliometric reference. Web Science core collection database was retrieved for from 1 January 2000 17 March 2020. Duplicates discrete papers were excluded. Analysis parameters including time, regions,...
Abstract As the Human Microbiome Project (HMP) progresses, relationship between microbes and human health has been receiving increasing attention. A growing number of reports support correlation cancer microbes. However, most studies have focused on bacteria, rather than fungal communities. In this study, we studied alteration in lung mycobiome patients with non-small-cell (NSCLC) using metagenomic sequencing qPCR. The higher diversity more complex network were observed NSCLC. addition,...
Monkeypox is a zoonotic viral disease caused by monkeypox virus infection and formerly this had been endemic mainly in Africa. Since May 2022, the has rapidly spread across world some imported case was confirmed sporadically China. Under these circumstances, data of cases were collected consecutively Chengdu, southwest China to investigate clinical epidemiological characteristics. In study, 28 male patients have infection, with 26 identifying as MSM (men who sex men). Typical lesions...
Teaching large language models (LLMs) to critique and refine their outputs is crucial for building systems that can iteratively improve, yet it fundamentally limited by the ability provide accurate judgments actionable suggestions. In this work, we study LLM critics code generation propose $\texttt{CTRL}$, a framework $\texttt{C}$ritic $\texttt{T}$raining via $\texttt{R}$einforcement $\texttt{L}$earning, which trains critic model generate feedback maximizes correction performance fixed...
Gastrointestinal (GI) cancers, which predominantly manifest in the stomach, colorectum, liver, esophagus, and pancreas, accounting for approximately 35% of global cancer-related mortality. The advent liquid biopsy has introduced a pivotal diagnostic modality early identification premalignant GI lesions incipient cancers. This non-invasive technique not only facilitates prompt therapeutic intervention, but also serves as critical adjunct prognosticating likelihood tumor recurrence. wealth...
Objective:The study was designed to evaluate the role of Human cytomegalovirus (HCMV) infection on homebox (HOX) gene expression and effects overexpression HOX genes proliferation apoptosis vascular smooth muscle cells (VSMCs). Methods: Viral verified by observation cytopathic through inverted microscopy, viral particles electron microscopy HCMV IE amplification RT-PCR. cDNA profiling technology used screen after in VSMCs. Abnormal Haematopoietically-expressed homeobox (HHEX) selected...
Differentially expressed microribonucleic acids (miRNAs) in the placenta and circulating exosomes are of diagnostic value for gestational diabetes mellitus (GDM). In a cross-sectional study, we identified miRNAs both pregnant women with GDM, estimated their value.Next-generation sequencing was used to identify that were differentially between GDM normal glucose tolerance pregnancies. Quantitative polymerase chain reaction validate targets. Western blot transmission electron microscopy...
Dietary habits have been proven to help alter the composition of gut microbiota, and exploring impact nutritional patterns on microbiota changes can protect health. However, few studies focused dietary over an experimental timeframe. In this study, 16S rRNA gene sequencing was employed investigate mice under different patterns, including AIN-93G diet (Control), high protein (HPD), fiber (HFD), switch (Switch). The alpha diversity HPD group significantly decreased, but HFD restore decline....
Abstract In the bone immune microenvironment, cells can regulate osteoblasts through a complex communication network. Macrophages play central role in mediating osteogenesis, exosomes derived from them have osteogenic regulation and be used as carriers tissue engineering. However, there are problems with exosomal therapy alone, such poor targeting, content of loaded molecules cannot reach therapeutic concentration. this study, macrophage-derived modified miR-365-2-5p were developed to...
Existing data on the genotype distribution of human papillomavirus (HPV) are limited in Hunan province, central south China. To evaluate prevalence HPV infection and its among women with invasive cervical cancer Hunan, a total 1,336 patients were included this study between July 2012 June 2013. Eighteen high-risk eight low-risk genotypes detected by Luminex xMAP technology. The results show that was 75.7%. A single found 82.3% HPV-positive samples, 91.8% cases had infection. most common type...
Highlights•Individuals with Bethesda category IV thyroid nodules are subtyped using an AI model•AI-based method can serve as a supplement to fine needle aspiration cytology (FNAC)•The management of could be changed by technologySummaryThyroid common disease, and (FNAC) is the primary assess their malignancy. For diagnosis follicular nodules, however, FNAC has limitations. classify them only leaving exact malignant status pathological type undetermined. This imprecise creates difficulties in...
Background: The present study was designed to observe the infection of human cytomegalovirus (HCMV) vascular smooth muscle cells (VSMCs), and effect viral on lipid metabolism in VSMCs. Methods: cytopathic effects were observed by inverted microscopy examined electron RT-PCR. related gene profiling VSMCs after HCMV assayed cDNA assay abnormal expression genes validated quantitative content cholesterol detection kit. Results: showed obvious infection. Intact particles could be detected using...
Abstract Hepatocyte nuclear factors 4 alpha (HNF4α) and 3 beta (HNF3β) are members of a group liver-enriched transcription (LETFs) that play important roles in regulating the replication hepatitis B virus (HBV) liver inflammation. However, relationship level HNF4α HNF3β with severity HBV-infected diseases is unclear. In this study, tissue samples from different types HBV patients were collected, expression detected by immunohistochemistry. The was significant higher severe B(SHB) than those...
ABSTRACT The switch of Kaposi's sarcoma-associated herpesvirus (KSHV) from latency to lytic replication is a key event for viral dissemination and pathogenesis. MLN4924, novel neddylation inhibitor, reportedly causes the onset KSHV reactivation but impairs later phases program in infected cells. Thus far, molecular mechanism involved modulation cycle by MLN4924 not yet fully understood. Here, we confirmed that treatment different KSHV-infected primary effusion lymphoma (PEL) cell lines with...
HIV-1 latency is a major obstacle for eradication. Extensive efforts are being directed toward the reactivation of latent HIV reservoirs with aim eliminating latently infected cells via host immune system and/or virus-mediated cell lysis.We screened over 1,500 small molecules and kinase inhibitors found that molecule, PKC412 (midostaurin, broad-spectrum inhibitor), can stimulate viral transcription expression from ACH2 line primary resting CD4+ T cells. reactivated in dose- time-dependent...
// Pey-Jium Chang 1, 2, 3 , Yao-Hsu Yang 4, 5, 6, 7 Pau-Chung Chen 8 Lee-Wen 9, 10 Shie-Shan Wang Ying-Ju Shih 1 Li-Yu Chi-Jen 5 Chien-Hui Hung and Chun-Liang Lin Graduate Institute of Clinical Medical Sciences, College Medicine, Chang-Gung University, Taoyuan, Taiwan 2 Department Nephrology, Memorial Hospital, Chiayi, Kidney Diabetic Complications Research Team (KDCRT), 4 Traditional Chinese Center Excellence for Gung Datalink, 6 Occupational Medicine Industrial Hygiene, National University...