A5100691684- Prostate Cancer Treatment and Research
- Estrogen and related hormone effects
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Molecular Junctions and Nanostructures
- Inflammatory Bowel Disease
- Bacterial Genetics and Biotechnology
- Photosynthetic Processes and Mechanisms
- Microscopic Colitis
- Liver Disease and Transplantation
- Plant biochemistry and biosynthesis
- Biochemical and biochemical processes
- Wnt/β-catenin signaling in development and cancer
- Enzyme Production and Characterization
- Microbial Metabolic Engineering and Bioproduction
- Steroid Chemistry and Biochemistry
- Circular RNAs in diseases
- Connective tissue disorders research
- Diagnosis and treatment of tuberculosis
- Cancer Immunotherapy and Biomarkers
- Eosinophilic Esophagitis
- Cell death mechanisms and regulation
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Photochemistry and Electron Transfer Studies
Xiangya Hospital Central South University
2025
Central South University
2024-2025
Sun Yat-sen University
2022-2023
State Key Laboratory of Oncology in South China
2022-2023
Sun Yat-sen University Cancer Center
2022-2023
Tongji Hospital
2023
Huazhong University of Science and Technology
2023
Longgang Central Hospital
2023
First Affiliated Hospital of Anhui Medical University
2023
Anhui Medical University
2023
An artificial intelligence-generated content-enhanced computer-aided diagnosis (AIGC-CAD) model, designated as ThyGPT, has been developed. This inspired by the architecture of ChatGPT, could assist radiologists in assessing risk thyroid nodules through semantic-level human-machine interaction. A dataset comprising 19,165 nodule ultrasound cases from Zhejiang Cancer Hospital was assembled to facilitate training and validation model. After training, ThyGPT automatically evaluate engage...
Background. Prostate cancer (PCa) harms the male reproductive system, and lncRNA may play an important role in it. Here, we report that LINC01088/microRNA- (miRNA/miR-) 22/cell division cycle 6 (CDC6) axis regulated through phosphatidylinositide 3-kinases- (PI3K-) protein kinase B (AKT) signaling pathway controls development of PCa. Methods. lncRNA/miRNA/mRNA associated with PCa was downloaded analyzed by Gene Expression Omnibus. The expression correlation LINC01088/miR-22/CDC6 were verified...
Highlights•Individuals with Bethesda category IV thyroid nodules are subtyped using an AI model•AI-based method can serve as a supplement to fine needle aspiration cytology (FNAC)•The management of could be changed by technologySummaryThyroid common disease, and (FNAC) is the primary assess their malignancy. For diagnosis follicular nodules, however, FNAC has limitations. classify them only leaving exact malignant status pathological type undetermined. This imprecise creates difficulties in...
Abstract Objectives Mucosal healing (MH) is an important goal in the treatment of patients with Crohn’s disease (CD). Noninvasive assessment MH normalized iodine concentration (NIC) unknown. Methods In this retrospective study, 94 diagnosed CD underwent endoscopy and dual-energy CT enterography (DECTE) at post-infliximab review. Two radiologists reviewed DECTE images by consensus for assessing diseased bowel segments colon or terminal ileum, NIC was measured. Patients were divided into...
Steroid-resistant nephrotic syndrome (SRNS) is a clinical characterized by the lack of response to standard steroid therapy, usually progressing end-stage renal disease. We reported two cases female identical twins with SRNS caused SGPL1 variants in one family, reviewed relevant literature, and summarized their phenotypes, pathological types, genotypic characteristics.Two were admitted Tongji Hospital, affiliated Medical College Huazhong University Science Technology. Their data...
Background Estrogen/estrogen receptor signaling influences the tumor microenvironment and affects efficacy of immunotherapy in some tumors, including melanoma. This study aimed to construct an estrogen response-related gene signature for predicting response Methods RNA sequencing data 4 immunotherapy-treated melanoma datasets TCGA was obtained from open access repository. Differential expression analysis pathway were performed between responders non-responders. Using dataset GSE91061 as...
Abstract Cisplatin-based nanoparticles show good potential in enhancing the effect of nasopharynx carcinoma (NPC) therapy but are still limited by their low radiation sensitization and poor tumor targeting ability. Herein, an ingenious design multifunctional superparamagnetic iron oxide nanoparticle (SPION)@polymer hybrid nanosensitizer (SPHN) with enhanced radiosensitization dual-targeting capability is described. SPHN have a core-shell structure, which radiosensitizer particle (SPION)...
To evaluate correlation between contrast-enhanced ultrasonography Liver Imaging Reporting and Data System (CEUS LI-RADS; v. 2017) categories (LR 3-5
The power conversion efficiency (PCE) of an organic solar cell (OSC) mainly depends on the chemical structures and intrinsic properties its active layer materials. development new nonfullerene acceptors (NFAs) has significantly boosted PCEs OSCs over last decade. Herein, two carbon-oxygen-bridged fused nonacyclic donor units were developed to synthesize NFAs, namely TTPIC-Ar iTTPIC-Ar, respectively. PM6:iTTPIC-Ar blend film displays clearer phase separation with subtler narrower nanofiber...
To analyze the serological characteristics and molecular mechanism for an individual with p phenotype.An phenotype upon blood group identification at Jiaxing Blood Center in May 2021 was analyzed. ABO, RhD P1PK groups irregular antibodies her serum were identified using conventional methods. The encoding region of α1, 4-galactosyltransferase gene (A4GALT) P1 Pk antigens analyzed by polymerase chain reaction-sequence-based typing (PCR-SBT).The A group, positive had a system. Anti-PP1Pk...
δ-catenin is a member of the Armadillo repeat family and component adherens junction discovered in two-hybrid assay as bona fide interactor with presenilin-1 (Zhou et al., [1997], NeuroReport 8:2085–2090), protein which carries mutations that cause familial Alzheimer's disease. The expression pattern was mapped between embryonic day 10 (E10) adulthood by Northern blots, situ hybridization immunohistochemistry mouse. In development, dynamically regulated respect to its site expression. It...
<div>Abstract<p>Reactivation of androgen receptor (AR) appears to be the major mechanism driving resistance castration-resistant prostate cancer (CRPC) second-generation antiandrogens and involves AR overexpression, mutation, and/or expression splice variants lacking ligand-binding domain. There is a need for novel small molecules targeting AR, particularly those also such as ARv7. A high-throughput/high-content screen was previously reported that led discovery lead compound,...
<p>Supplementary Figures S1-S7</p>
<p>Supplementary Figures S1-S7</p>
<div>Abstract<p>Reactivation of androgen receptor (AR) appears to be the major mechanism driving resistance castration-resistant prostate cancer (CRPC) second-generation antiandrogens and involves AR overexpression, mutation, and/or expression splice variants lacking ligand-binding domain. There is a need for novel small molecules targeting AR, particularly those also such as ARv7. A high-throughput/high-content screen was previously reported that led discovery lead compound,...