A5100755034- Cosmology and Gravitation Theories
- Galaxies: Formation, Evolution, Phenomena
- Black Holes and Theoretical Physics
- Astronomy and Astrophysical Research
- Gamma-ray bursts and supernovae
- Radio Astronomy Observations and Technology
- Pulsars and Gravitational Waves Research
- Dark Matter and Cosmic Phenomena
- Astrophysics and Cosmic Phenomena
- Geophysics and Gravity Measurements
- Particle physics theoretical and experimental studies
- Advanced Differential Geometry Research
- Relativity and Gravitational Theory
- Astrophysical Phenomena and Observations
- Neutrino Physics Research
- Earth Systems and Cosmic Evolution
- Stellar, planetary, and galactic studies
- Cancer Immunotherapy and Biomarkers
- Computational Physics and Python Applications
- Atomic and Subatomic Physics Research
- Advanced Computational Techniques and Applications
- Quantum, superfluid, helium dynamics
- Immune cells in cancer
- Solar and Space Plasma Dynamics
- Quantum Chromodynamics and Particle Interactions
Shanghai Jiao Tong University
2017-2025
Shanghai Cancer Institute
2022-2025
Universitat de València
2023-2024
Instituto de Física Corpuscular
2023-2024
National Astronomical Observatories
2019-2023
Chinese Academy of Sciences
2019-2023
State Key Laboratory of Oncogene and Related Genes
2021-2023
Inner Mongolia University
2022
Shanghai Astronomical Observatory
2019-2020
University of Science and Technology Beijing
2020
Cell plasticity and neuroendocrine differentiation in prostate lung adenocarcinomas are one of the major reasons for therapeutic resistance to targeted therapy. Whether how metabolic changes contribute this adenocarcinoma-to-neuroendocrine cell fate transition remains largely unclear. Here we show that or cancer cells possess mostly fragmented mitochondria with low membrane potential rely on glycolysis energy metabolism. We further an important role determinant Numb mitochondrial quality...
The accelerated expansion of the universe is most debatable cosmological scenario in last two decades. Looking for proper explanation this scenario, researchers have presented a lot proposals to discuss it. However, somehow, proposal seems incomplete and needs improve better representation universe. Therefore, thesis aims investigate some problems searching an accurate universe...
The DESI year one observations can help probe new physics on cosmological scales. In light of the latest BAO measurements, we constrain four popular scenarios including inflation, modified gravity, annihilating dark matter and interacting energy. Using a data combination BICEP/Keck array, cosmic microwave background DESI, obtain $1\sigma$ $2\sigma$ constraints tensor-to-scalar ratio $r_{0.05}= 0.0176^{+0.0070}_{-0.0130}$ $r_{0.05}=0.018^{+0.020}_{-0.017}$. find $2.4\sigma$ evidence for...
Low-redshift probes, such as baryon acoustic oscillations (BAO) and supernovae Ia luminosity distances, have been shown to be crucial for improving the bounds on total neutrino mass from cosmological observations, due their ability break degeneracies among different parameters. Here, we expand background observations include $H(z)$ measurements cosmic chronometers, distance moduli gamma ray bursts (GRBs), angular diameter distances galaxy clusters. For first time, using physically motivated...
Motivated by the discrepancy in measurements of ${H}_{0}$ between local and global probes, we investigate whether teleparallel gravities could be a better model to describe present-day observations or at least alleviate tension. Specifically, this work study place constraints on three popular $f(T)$ models light Planck-2018 cosmic microwave background data release. We find that power-law can tension from $4.4\ensuremath{\sigma}$ $1.9\ensuremath{\sigma}$ level, while two exponentials fails...
We perform a comprehensive study of the dark energy equation state (EoS) utilizing model-independent Gaussian processes (GP). Using combination Union 2.1 data set, 30 newly added H(z) cosmic chronometer points and Planck's shift parameter, we modify usual GaPP code provide tighter constraint on EoS than previous literature about GP reconstructions. Subsequently, take ``controlling variable method '' to investigate directly effects matter density parameter...
Great attention is paid to the role of androgen receptor (AR) as a central transcriptional factor in driving growth prostate cancer (PCa) epithelial cells. However, understanding PCa-infiltrated immune cells and impact deprivation therapy (ADT), first-line treatment for advanced PCa, on PCa microenvironment remains limited. On other hand, checkpoint blockade has revolutionized certain types, but fails achieve any benefit due an suppressive environment. In this study, it reported that AR...
Serotonin (5-HT) is a neurotransmitter that has been linked to tumorigenesis. Whether and how 5-HT modulates cells in the microenvironment regulate tumor metastasis remains be largely unknown. Here, we demonstrate secreted by neuroendocrine prostate cancer (NEPC) communicate with neutrophils induce neutrophil extracellular traps (NETs) liver, which turn facilitates recruitment of disseminated promotes liver metastasis. induces histone serotonylation (H3Q5ser) orchestrates citrullination...
In the present paper, exact solutions of spherically symmetrical Einstein field equations describing wormholes supported by phantom energy that violates null condition from Shan–Chen background fluid are obtained. We have considered important case model parameter $$\psi \approx 1$$ , which corresponds to "saturation effect", and this regime an effective form "asymptotic freedom" for fluids, but occurring at cosmological rather than subnuclear scales. Then we investigate allowed range values...
JWST high redshift galaxy observations predict a higher star formation efficiency than the standard cosmology does, which poses new tension to $\Lambda$CDM. We find that situation is worse expected. The true Planck CMB measurement has strong with observations. Specifically, we make trial alleviate this by considering alternative cosmological models including dark matter-baryon interaction, $f(R)$ gravity and dynamical energy. Within current constraints from Planck-2018 data, these all fail...
Based on the assumption that dark energy possessing bulk viscosity is homogeneously and isotropically permeated in universe, we propose three new viscous (VDE) models to characterize accelerating universe. By constraining these with latest cosmological observations, find they just deviate very slightly from standard model can alleviate effectively current $$H_0$$ tension between local observation by Hubble Space Telescope global measurement Planck Satellite. Interestingly, conclude a...
We use the latest Type Ia supernovae sample Pantheon+ to explore new physics on cosmic scales. Specifically, in light of this sample, we constrain interacting dark energy and Hu-Sawicki $f(R)$ gravity models employ model-independent Gaussian processes investigate whether there is an evidence evolution. find that alone just gives weak constraints. However, a data combination with microwave background, baryon acoustic oscillations chronometers strong constraint modified matter expansion rate...
In this letter, we investigate the traversable wormholes in holographic dark energy (HDE) model constrained by modern astronomical observations. First of all, constrain HDE adopting different data-sets, explore cosmological background evolution model, and find that will be fitting better than Ricci (RDE) for same SNe Ia data-sets using so-called Akaike Information Criterions (AIC) Bayesian (BIC) . Furthermore, discover if taking appear (open) when redshift $z<0.027$. Subsequently, several...
We propose a new pressure-parametrization model to explain the accelerated expansion of late-time Universe by considering baryon matter and dark contents (dark energy) as unified fluid. To realize this more physically, we reconstruct it with quintessence phantom scalar fields, respectively. use recent cosmological data constrain model, distinguish from standard find that value Hubble constant $$H_0=68.34^{+0.53}_{-0.92}$$ supports global measurement Planck satellite at $$1\sigma $$ confidence level.