A5046119338- Prostate Cancer Treatment and Research
- Chronic Myeloid Leukemia Treatments
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Acute Myeloid Leukemia Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Coronary Interventions and Diagnostics
- Cancer, Stress, Anesthesia, and Immune Response
- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- Antiplatelet Therapy and Cardiovascular Diseases
- Pancreatic function and diabetes
- Kruppel-like factors research
- Advanced Materials and Mechanics
- Eosinophilic Disorders and Syndromes
- Cardiovascular Issues in Pregnancy
- Immune Cell Function and Interaction
- Micro and Nano Robotics
- Neuroinflammation and Neurodegeneration Mechanisms
- Modular Robots and Swarm Intelligence
- T-cell and B-cell Immunology
- Hippo pathway signaling and YAP/TAZ
- Receptor Mechanisms and Signaling
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
Shanghai Cancer Institute
2022-2025
Shanghai Jiao Tong University
2019-2025
Zhengzhou University
2024
State Key Laboratory of Oncogene and Related Genes
2019-2023
Serotonin (5-HT) is a neurotransmitter that has been linked to tumorigenesis. Whether and how 5-HT modulates cells in the microenvironment regulate tumor metastasis remains be largely unknown. Here, we demonstrate secreted by neuroendocrine prostate cancer (NEPC) communicate with neutrophils induce neutrophil extracellular traps (NETs) liver, which turn facilitates recruitment of disseminated promotes liver metastasis. induces histone serotonylation (H3Q5ser) orchestrates citrullination...
Great attention is paid to the role of androgen receptor (AR) as a central transcriptional factor in driving growth prostate cancer (PCa) epithelial cells. However, understanding PCa-infiltrated immune cells and impact deprivation therapy (ADT), first-line treatment for advanced PCa, on PCa microenvironment remains limited. On other hand, checkpoint blockade has revolutionized certain types, but fails achieve any benefit due an suppressive environment. In this study, it reported that AR...
Cell lineage plasticity is one of the major causes for failure targeted therapies in various cancers. However, driver and actionable drug targets promoting cancer cell are scarcely identified. Here, we found that a G protein-coupled receptor, ADORA2A, specifically upregulated during neuroendocrine differentiation, common form prostate lung following therapies. Activation ADORA2A signaling rewires proline metabolism via an ERK/MYC/PYCR cascade. Increased synthesis promotes deacetylases...
Abstract The diverse repertoire of T cell receptors (TCR) and immunoglobulins is generated through the somatic rearrangement respective V, D J gene segments, termed V(D)J recombination, during early or B development. However, epigenetic regulation recombination still not fully understood. Here we show that deficiency Setd2, a histone methyltransferase catalyzes lysine 36 trimethylation on 3 (H3K36me3) in mice, causes severe developmental block thymocytes at CD4 − CD8 DN3 stage. While...
Abstract Objectives Epigenetic modifiers were important players in the development of haematological malignancies and sensitivity to therapy. Mutations SET domain‐containing 2 (SETD2), a methyltransferase that catalyses trimethylation histone 3 on lysine 36 (H3K36me3), found various myeloid malignancies. However, detailed mechanisms through which SETD2 confers chronic leukaemia progression resistance therapy targeting BCR‐ABL remain unclear. Materials methods The level imatinib‐sensitive...
Abstract Objectives In contrast to extensive studies on bone metastasis in advanced prostate cancer (PCa), liver has been under‐researched so far. order decipher molecular and cellular mechanisms underpinning of PCa, we develop a rapid immune sufficient mouse model for PCa via orthotopic injection organoids from PbCre + ; rb1 f/f ;p53 mice. Materials Methods pten mice were used generate organoid cultures vitro. Immune models established transplantation into the C57BL/6 Immunofluorescent...
ABSTRACT Background After drug-coated balloon (DCB) angioplasty in patients with de novo coronary lesions, dissections can result the continuous presence of thrombi within vessel wall, potentially leading to late luminal loss. Rivaroxaban, a novel oral anticoagulant, may mitigate lumen loss attributable dissection. Objectives This study was conducted evaluate effectiveness and safety low-dose rivaroxaban improving outcomes for following DCB intervention. Methods trial prospective,...
In this paper, a serial reconfigurable modular robot is presented. Each module cubic structure. surface of cube has connection interface. It three rotational degrees freedom, which are distributed along the directions its local coordinate system. A new and reliable docking mechanism designed to realize among adjacent modules. With novel structure, vibration negligible. Then, based on characteristics module, an eigenvector describe state information single adjacency matrix express topology...