Abstract The infection of the novel coronavirus severe acute respiratory syndrome 2 (SARS-CoV-2) has caused more than 200 000 deaths, but no vaccine or therapeutic monoclonal antibody is currently available. SARS-CoV-2 relies on its spike protein, in particular receptor-binding domain (RBD), to bind human cell receptor angiotensin-converting enzyme (ACE2) for viral entry, and thus targeting RBD holds promise preventing infection. In this work, a competitive biopanning strategy phage display...

Abstract Recent advancements in CNN and Transformer-based models have significantly advanced medical image segmentation. CNN-based are less effective at capturing global contexts than Transformers structural disadvantages that limit their ability to capture detailed spatial information. In this paper, we introduce an Dual-Encoder Fusion Model incorporates a novel Correlation Module (CFM) for segmentation tasks. This model leverages the strengths of Convolutional Neural Networks (CNN) local...

Objective:The study was designed to evaluate the role of Human cytomegalovirus (HCMV) infection on homebox (HOX) gene expression and effects overexpression HOX genes proliferation apoptosis vascular smooth muscle cells (VSMCs). Methods: Viral verified by observation cytopathic through inverted microscopy, viral particles electron microscopy HCMV IE amplification RT-PCR. cDNA profiling technology used screen after in VSMCs. Abnormal Haematopoietically-expressed homeobox (HHEX) selected...

Objective— To identify circulating microRNAs that are differentially expressed in severe coronary heart disease with well or poorly developed collateral arteries and to investigate their mechanisms of action vivo vitro. Approach Results— In our study, we identified a microRNA, miR-15b-5p, low expression that, nevertheless, characterized patients sufficient artery function. Moreover, murine hindlimb ischemia model, situ hybridization miR-15b-5p was specifically vascular endothelial cells...

Influenza epidemics pose a threat to human health. It has been reported that meteorological factors (MFs) are associated with influenza. This study aimed explore the similarities and differences between influences of more comprehensive MFs on influenza in cities different economic, geographical climatic characteristics Fujian Province. Then, information was used predict daily number cases various based provide bases for early warning systems outbreak prevention.

Reputation is critical to foster trust in online marketplaces, yet leaving feedback a public good that can be under-provided unless buyers are rewarded for it.Signaling theory implies only high quality sellers would reward truthful feedback.We explore this scope signaling using Taobao's "reward-for-feedback" mechanism and find items with rewards generate sales nearly 30%higher sold by higher sellers.The market design implication marketplaces benefit from allowing use build reputations signal...

Alzheimer's disease (AD) stands as the most prevalent neurodegenerative ailment, presently lacking a definitive cure. Given that primary medications for AD patients in early or middle stages demonstrate optimal efficacy, it becomes crucial to delve into identification of risk genes associated with onset. In our study, we compiled and integrated three transcriptomics datasets (GSE48350, GSE36980, GSE5281) originating from hippocampus 37 66 healthy controls (CTR) comprehensive bioinformatics...

This paper presents a framework with two automatic tasks targeting large-scale and low quality sports video archives collected from online streams. The is based on the bag of visual-words model using speeded-up robust features (SURF). first task genre categorization hierarchical structure. Following second which automatically obtained genre, views are classified support vector machines (SVMs). As consequence, classification result can be used in parsing highlight extraction. compared...

Abstract Background This study adopted complete meteorological indicators, including eight items, to explore their impact on hand, foot, and mouth disease (HFMD) in Fuzhou, predict the incidence of HFMD through long short-term memory (LSTM) neural network algorithm artificial intelligence. Method A distributed lag nonlinear model (DLNM) was used analyse influence factors Fuzhou from 2010 2021. Then, numbers cases 2019, 2020 2021 were predicted using LSTM multifactor single-step multistep...

Background: The present study was designed to observe the infection of human cytomegalovirus (HCMV) vascular smooth muscle cells (VSMCs), and effect viral on lipid metabolism in VSMCs. Methods: cytopathic effects were observed by inverted microscopy examined electron RT-PCR. related gene profiling VSMCs after HCMV assayed cDNA assay abnormal expression genes validated quantitative content cholesterol detection kit. Results: showed obvious infection. Intact particles could be detected using...

Cadmium (Cd) can influence germ cell development, and epigenetic events may be involved. However, there is no study on whether Cd cells differentiation into ovarian granulosa (GCs), more insight the molecular mechanism of effect development from mouse embryonic stem (ES) investigation appropriate factors are great importance. In this study, ES GCs was established in an vitro model. Subsequently, different concentrations 0, 0.1, 0.3, 1 then 3.0, 10.0 μmol/L were cultured We demonstrated that...

At different times, public health faces various challenges and the degree of intervention measures varies. The research on impact prediction meteorology factors influenza is increasing gradually, however, there currently no evidence whether its results are affected by periods. This study aims to provide limited reveal this issue.

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a specific cell-surface receptor for oxidized-low-density (ox-LDL). The impact of high-density (HDL) on endoplasmic reticulum (ER) stress-mediated alteration the LOX-1 level in hepatocytes remains unclear. We aimed to investigate expression by tunicamycin (TM)-induced ER stress and determine effect HDL TM-affected hepatic L02 cells. Overexpression or silencing related cellular genes was conducted TM-treated mRNA evaluated...

Abstract The infection of the novel coronavirus SARS-CoV-2 have caused more than 150,000 deaths, but no vaccine or specific therapeutic antibody is currently available. relies on its spike protein, in particular receptor binding domain (RBD), to bind human cell angiotensin-converting enzyme 2 (ACE2) for viral entry, and thus targeting RBD holds promise preventing infection. In this work, a competitive biopanning strategy phage display library was applied screen blocking antibodies against...

Various innovative and original works have been applied proposed in the field of sports video analysis. However, individual focused on sophisticated methodologies with particular sport types there has a lack scalable holistic frameworks this field. This article proposes solution presents systematic generic approach which is experimented relatively large-scale consortia. The system aims at event detection scenario an input orderly sequential process. Initially, domain knowledge-independent...

This paper presents an efficient and robust automatic process for large-scale sports video analysis. The proposed system firstly identifies the genre of query video, then accomplishes interesting event detection task. significance this framework is its characteristic in testing with minimum human involvement training, as well scalability expansibility dealing a dataset. Domain-knowledge independent local features are extracted from input sequence histogram based distribution representation...

Swarm intelligence is a research branch that models the population of interacting agents or swarms are able to self-organize. An ant colony, flock birds an immune system typical example swarm system. Bees’ swarming around their hive another intelligence. The Artificial Bee Colony algorithm optimization based on intelligent behavior honey bee swarm. This paper presents Optimization intended introduce chaotic sequences into algorithm. On basis Algorithm, new by introducing constructing dynamic...