A5100657096- Endoplasmic Reticulum Stress and Disease
- Angiogenesis and VEGF in Cancer
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Advanced Glycation End Products research
- Cholesterol and Lipid Metabolism
- Chronic Kidney Disease and Diabetes
- Cancer, Lipids, and Metabolism
- Engineering Education and Curriculum Development
- Gut microbiota and health
- Neurological and metabolic disorders
- Pharmacology and Obesity Treatment
- Genetic Associations and Epidemiology
- Diet and metabolism studies
- Helicobacter pylori-related gastroenterology studies
- TGF-β signaling in diseases
- Coronary Interventions and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Mesenchymal stem cell research
- Tuberous Sclerosis Complex Research
- Chemical synthesis and alkaloids
- Fungal Biology and Applications
- Lipid metabolism and disorders
- Cancer-related molecular mechanisms research
- Biomarkers in Disease Mechanisms
Xiangya Hospital Central South University
2014-2023
Central South University
2013-2023
Beijing Tian Tan Hospital
2022
Capital Medical University
2022
Second Xiangya Hospital of Central South University
2015-2018
PharmacoGenetics (China)
2018
Emerging studies suggest that lipid accumulates in the kidneys during diabetic kidney disease (DKD). However, correlation between ectopic accumulation with tubular damage has not been thoroughly elucidated to date. Using Oil Red staining, was observed of type 2 DKD patients (classes II–III) and db/db mice compared control predominantly located proximal compartment. Immunohistochemistry (IHC) staining showed intensity adipose differentiation related protein (ADRP) sterol regulatory element...
The high mobility group 1B protein (HMGB1) mediates chronic inflammatory responses in endothelial cells, which play a critical role atherosclerosis. However, the underlying mechanism is unknown. goal of our study was to identify effects HMGB1 on RAGE-induced response cells and test possible involvement endoplasmic reticulum stress pathway. Our results showed that incubation with (0.01-1 μg/ml) for 24h induced dose-dependent activation transducers, as assessed by PERK IRE1 expression....
Transforming growth factor-β1 (TGF-β1) plays a key role in mesothelial-to-mesenchymal transition (MMT) during peritoneal dialysis (PD). However, the of Akt MMT transformation PD is not clear.In this study, we observed that phosphorylated form protein kinase B (Akt), termed as pAkt, was up-regulated peritoneum mice undergoing PD. It associated with thickening and up-regulation TGF-β1. Upregulation pAkt paralleled increased expression Smad ubiquitination regulatory factor 2 (Smurf2), Vimentin...
Coronary collateral circulation (CCC) is crucial during an acute ischemic attack. Evidences showed that omentin-1 exhibited remarkable antiatherogenic effects and ischemia-induced revascularization. The aim of this study was to investigate the relationship between plasma levels CCC in patients with ≥90% angiography-proven coronary occlusion.142 luminal diameter stenosis at least one major epicardial artery were recruited. Among them, 79 Rentrop 0-1 grade classified into poor group 63 2-3...
Background: Previous studies have indicated that the gut microbiota (GM) is associated with coronary artery disease (CAD), but causality of these associations remains unestablished due to confounding factors and reverse causality. We conducted Mendelian randomization study (MR) determine causal effect specific bacterial taxa on CAD/myocardial infarction (MI) identify mediating involved. Methods: Two-sample MR, multivariable MR (MVMR) mediation analysis were performed. Inverse-variance...
Hemophilia B occurs due to a deficiency in human blood coagulation factor IX (hFIX). Currently, no effective treatment for hemophilia has been identified, and gene therapy considered the most appropriate treatment. Mesenchymal stem cells (MSCs) have homing abilities low immunogenicity, therefore they may be potential cell carriers targeted drug delivery lesional tissues. The present study constructed an adeno‑associated virus integration site 1 (AAVS1)‑targeted vector termed AAVS1‑green...
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a specific cell-surface receptor for oxidized-low-density (ox-LDL). The impact of high-density (HDL) on endoplasmic reticulum (ER) stress-mediated alteration the LOX-1 level in hepatocytes remains unclear. We aimed to investigate expression by tunicamycin (TM)-induced ER stress and determine effect HDL TM-affected hepatic L02 cells. Overexpression or silencing related cellular genes was conducted TM-treated mRNA evaluated...
Endothelial progenitor cells (EPCs) have endogenous endothelium-reparative potential, but obesity impairs EPCs. Overweight premenopausal women a normal number of circulating EPCs with functional activity, whether in overweight postmenopausal can repair obesity-related endothelial damage requires further investigation. For this purpose, we examined the function and EPCs, evaluated vascular function, explored underlying mechanism. Compared weight or age-matched men, (overweight weight) had...
To investigate nursing students' knowledge of and attitudes about problem-based learning (PBL). A total 1200 students were surveyed at eight colleges in Hunan Province. In all, 1037 valid questionnaires returned, for an effective return rate 86.4%. Some 54.4% the learned that PBL was a pedagogical method from teachers, 27.8% had participated courses. Almost all (97.6%) interested PBL, 66.7% survey participants believed who not good solving problems would have difficulty Nursing educators...
Endothelial progenitor cells (EPCs) contribute to the endogenous endothelial repair program during hypercholesterolemia. EPC count and migratory proliferative capacities remain unchanged in premenopausal female with However, changes of activity circulating EPCs hypercholesterolemic postmenopausal females are unknown. Here, we find that were decreased patients hypercholesterolemia versus normocholesterolemia. No significant differences found between age-matched males. NO production showed...
Objective: The small Peptide Transporter 1 (PepT-1) and Adipose phospholipase A2 (AdPLA) play a key role in the development of obesity. However, there are no data assessing impact PepT-1(SLC15A1) AdPLA (PLA2G16) variants on obesity susceptibility. Therefore, we assessed contribution 9 SNPs among these two genes susceptibility Chinese subjects.
Abstract Background Endothelial progenitor cells (EPCs) play an important role in vascular repair. However, the functions of EPCs are obviously weakened inflammatory microenvironment during restenosis. Therefore, we investigated whether omentin-1, anti-inflammatory factor, can reduce neointima formation after carotid artery injury (CAI) rats via improving damaged by inflammation and underlying mechanisms. Methods Rats bone marrow-derived were isolated cultured. transfected with adenovirus...