Lei Zhang

ORCID: 0000-0003-0421-2804
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About
Contact & Profiles
Research Areas
  • Gestational Diabetes Research and Management
  • Birth, Development, and Health
  • Pregnancy and preeclampsia studies
  • Vitamin D Research Studies
  • Sleep and related disorders
  • Neonatal and fetal brain pathology
  • Cancer-related molecular mechanisms research
  • Ovarian function and disorders
  • Maternal Mental Health During Pregnancy and Postpartum
  • Infant Nutrition and Health
  • Extracellular vesicles in disease
  • HIV-related health complications and treatments
  • Climate Change and Health Impacts
  • Ovarian cancer diagnosis and treatment
  • Obesity, Physical Activity, Diet
  • Reproductive System and Pregnancy
  • Circular RNAs in diseases

Anhui Medical University
2023-2025

Second Affiliated Hospital of Chongqing Medical University
2022

Dalian Medical University
2022

Chongqing Medical University
2022

Second Hospital of Shandong University
2021

Nanjing Drum Tower Hospital
2008

Differentially expressed microribonucleic acids (miRNAs) in the placenta and circulating exosomes are of diagnostic value for gestational diabetes mellitus (GDM). In a cross-sectional study, we identified miRNAs both pregnant women with GDM, estimated their value.Next-generation sequencing was used to identify that were differentially between GDM normal glucose tolerance pregnancies. Quantitative polymerase chain reaction validate targets. Western blot transmission electron microscopy...

10.1111/jdi.13493 article EN cc-by-nc-nd Journal of Diabetes Investigation 2021-01-11

Background Given the ease of access to ambient temperature, it may be a more practical guide than UVB index. However, association between gestational temperature and vitamin D level in newborns remains unclear. Our study aims explore this necessity maternal supplementation when is less specific value. Methods Based on birth cohort study, we measured cord blood concentrations 25(OH)D 1419 neonates from January September 2008 Hefei, new first-tier city China. The daily mean Hefei was obtained...

10.3389/fnut.2025.1541427 article EN cc-by Frontiers in Nutrition 2025-01-28

Gestational diabetes mellitus (GDM) is a risk factor for child neurodevelopmental delay. Maternal short sleep duration (SSD) may aggravate glucose metabolism disorder in women with GDM. However, it unclear whether maternal SSD will further affect the outcomes of children.To identify association GDM complicated and delay.This prospective study included 7069 mother-child pairs. Between 24 28 weeks gestation, was based on 75-g oral-glucose-tolerance test. Self-reported collected via Pittsburgh...

10.1210/clinem/dgad446 article EN The Journal of Clinical Endocrinology & Metabolism 2023-07-29

Background: Differentially expression of miRNAs in the placenta are involved development gestational diabetes mellitus (GDM). In a cross-sectional study, we investigated whether differentially expressed GDM have consistent pattern circulating exosomes and estimate diagnostic value. Method: The next-generation sequencing was used for identified compared with normal glucose tolerance (NGT). Gene target ontology enrichment analysis were to analyze miRNAs. area estimated value under ROC curve...

10.2139/ssrn.3557974 article EN SSRN Electronic Journal 2020-01-01

Abstract Background Fetal growth restriction seriously affects the health of newborns. However, cause FGR is unclear. Circular RNAs (CircRNAs) are a novel type endogenous noncoding that regulate target gene expression by interacting with microRNA (miRNA) .The present research was major in investigating regulation association among circCUL1, miR-30e, ATG7/14 and MAPK1 FGR, we explored mechanism underlying pathogenesis Results circCUL1 promotes autophagy placental trophoblast cells. Mechanism...

10.21203/rs.3.rs-1590810/v1 preprint EN cc-by Research Square (Research Square) 2022-05-03
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